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- W4283119411 abstract "Sjögren syndrome (SS) is an autoimmune disease in which immune cells infiltrate the exocrine gland. Since SS is caused by a disorder of the immune system, treatments should regulate the immune response. Sphingosylphosphorylcholine (SPC) is a sphingolipid that mediates cellular signaling. In immune cells, SPC has several immunomodulatory functions. Accordingly, this study verifies the immunomodulatory ability and therapeutic effect of SPC in SS. To understand the function of SPC in SS, we treated SPC in female NOD/ShiJcl (NOD) mice. The mice were monitored for 10 weeks, and inflammation in the salivary glands was checked. After SPC treatment, we detected the expression of regulatory B (Breg) cells in mouse splenocytes and the level of salivary secretion-related genes in human submandibular gland (HSG) cells. Salivary flow rate was maintained in the SPC-treated group compared to the vehicle-treated group, and inflammation in the salivary gland tissues was relieved by SPC. SPC treatment in mouse cells and HSG cells enhanced Breg cells and salivary secretion markers, respectively. This study revealed that SPC can be considered as a new therapeutic agent against SS." @default.
- W4283119411 created "2022-06-20" @default.
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- W4283119411 date "2022-08-01" @default.
- W4283119411 modified "2023-09-23" @default.
- W4283119411 title "Sphingosylphosphorylcholine ameliorates experimental sjögren's syndrome by regulating salivary gland inflammation and hypofunction, and regulatory B cells" @default.
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- W4283119411 cites W2006073149 @default.
- W4283119411 cites W2010720361 @default.
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- W4283119411 cites W2013262178 @default.
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- W4283119411 cites W2026731442 @default.
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- W4283119411 cites W2051655816 @default.
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- W4283119411 doi "https://doi.org/10.1016/j.imlet.2022.06.008" @default.
- W4283119411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35732207" @default.
- W4283119411 hasPublicationYear "2022" @default.
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