Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283120410> ?p ?o ?g. }
- W4283120410 abstract "Abstract Adeno-associated virus (AAV) vectors are promising modalities of gene therapy to address unmet medical needs. However, anti-AAV neutralizing antibodies (NAbs) hamper the vector-mediated therapeutic effect. Therefore, the NAb prevalence in the target population is vital in designing clinical trials with AAV vectors. Hence, updating the seroprevalence of anti-AAV NAbs, herein we analyzed sera from 100 healthy individuals and 216 hemophiliacs in Japan. In both groups, the overall seroprevalence against various AAV serotypes was 20%–30%, and the ratio of NAb-positive population increased with age. The seroprevalence did not differ between healthy participants and hemophiliacs and was not biased by the concomitant blood-borne viral infections. The high neutralizing activity, which strongly inhibits the transduction with all serotypes in vitro , was mostly found in the 60s or older age. The multivariate analysis suggested that “60s or older age” was the only independent factor related to the high titer of NAbs. Conversely, a large proportion of younger hemophiliacs was seronegative, rendering them eligible for AAV-mediated gene therapy in Japan. Compared with our previous study, the peak of seroprevalences has shifted to older populations, indicating natural AAV exposure in the elderly has occurred in their youth but not during the last decade." @default.
- W4283120410 created "2022-06-20" @default.
- W4283120410 creator A5006668050 @default.
- W4283120410 creator A5008757028 @default.
- W4283120410 creator A5013904946 @default.
- W4283120410 creator A5014396227 @default.
- W4283120410 creator A5017834677 @default.
- W4283120410 creator A5019169086 @default.
- W4283120410 creator A5021265535 @default.
- W4283120410 creator A5028010352 @default.
- W4283120410 creator A5030275427 @default.
- W4283120410 creator A5036949502 @default.
- W4283120410 creator A5038642951 @default.
- W4283120410 creator A5039621181 @default.
- W4283120410 creator A5043470607 @default.
- W4283120410 creator A5046568567 @default.
- W4283120410 creator A5047207626 @default.
- W4283120410 creator A5047434427 @default.
- W4283120410 creator A5053794590 @default.
- W4283120410 creator A5056608405 @default.
- W4283120410 creator A5059111765 @default.
- W4283120410 creator A5060046750 @default.
- W4283120410 creator A5060134340 @default.
- W4283120410 creator A5060462446 @default.
- W4283120410 creator A5063814340 @default.
- W4283120410 creator A5064140107 @default.
- W4283120410 creator A5068426528 @default.
- W4283120410 creator A5069888582 @default.
- W4283120410 creator A5074968901 @default.
- W4283120410 creator A5081465445 @default.
- W4283120410 creator A5084653151 @default.
- W4283120410 date "2022-06-17" @default.
- W4283120410 modified "2023-10-03" @default.
- W4283120410 title "The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs" @default.
- W4283120410 cites W1492446984 @default.
- W4283120410 cites W1969271703 @default.
- W4283120410 cites W1971284136 @default.
- W4283120410 cites W1976329054 @default.
- W4283120410 cites W2022161423 @default.
- W4283120410 cites W2026197669 @default.
- W4283120410 cites W2039881052 @default.
- W4283120410 cites W2049958940 @default.
- W4283120410 cites W2057767029 @default.
- W4283120410 cites W2070447470 @default.
- W4283120410 cites W2082025265 @default.
- W4283120410 cites W2086866768 @default.
- W4283120410 cites W2098898935 @default.
- W4283120410 cites W2157636936 @default.
- W4283120410 cites W2170205772 @default.
- W4283120410 cites W2220787769 @default.
- W4283120410 cites W2425744751 @default.
- W4283120410 cites W2611605599 @default.
- W4283120410 cites W2782917400 @default.
- W4283120410 cites W2789252604 @default.
- W4283120410 cites W2883141789 @default.
- W4283120410 cites W2894600652 @default.
- W4283120410 cites W2911391034 @default.
- W4283120410 cites W2933734725 @default.
- W4283120410 cites W2938657606 @default.
- W4283120410 cites W2947983278 @default.
- W4283120410 cites W2957860328 @default.
- W4283120410 cites W2968692721 @default.
- W4283120410 cites W2972931782 @default.
- W4283120410 cites W3035047148 @default.
- W4283120410 cites W3041796233 @default.
- W4283120410 cites W3104893422 @default.
- W4283120410 cites W3136247297 @default.
- W4283120410 cites W3167050415 @default.
- W4283120410 cites W3215722326 @default.
- W4283120410 cites W4212868305 @default.
- W4283120410 cites W4223525031 @default.
- W4283120410 cites W4300935278 @default.
- W4283120410 doi "https://doi.org/10.1101/2022.06.16.22276528" @default.
- W4283120410 hasPublicationYear "2022" @default.
- W4283120410 type Work @default.
- W4283120410 citedByCount "1" @default.
- W4283120410 countsByYear W42831204102022 @default.
- W4283120410 crossrefType "posted-content" @default.
- W4283120410 hasAuthorship W4283120410A5006668050 @default.
- W4283120410 hasAuthorship W4283120410A5008757028 @default.
- W4283120410 hasAuthorship W4283120410A5013904946 @default.
- W4283120410 hasAuthorship W4283120410A5014396227 @default.
- W4283120410 hasAuthorship W4283120410A5017834677 @default.
- W4283120410 hasAuthorship W4283120410A5019169086 @default.
- W4283120410 hasAuthorship W4283120410A5021265535 @default.
- W4283120410 hasAuthorship W4283120410A5028010352 @default.
- W4283120410 hasAuthorship W4283120410A5030275427 @default.
- W4283120410 hasAuthorship W4283120410A5036949502 @default.
- W4283120410 hasAuthorship W4283120410A5038642951 @default.
- W4283120410 hasAuthorship W4283120410A5039621181 @default.
- W4283120410 hasAuthorship W4283120410A5043470607 @default.
- W4283120410 hasAuthorship W4283120410A5046568567 @default.
- W4283120410 hasAuthorship W4283120410A5047207626 @default.
- W4283120410 hasAuthorship W4283120410A5047434427 @default.
- W4283120410 hasAuthorship W4283120410A5053794590 @default.
- W4283120410 hasAuthorship W4283120410A5056608405 @default.
- W4283120410 hasAuthorship W4283120410A5059111765 @default.
- W4283120410 hasAuthorship W4283120410A5060046750 @default.
- W4283120410 hasAuthorship W4283120410A5060134340 @default.
- W4283120410 hasAuthorship W4283120410A5060462446 @default.