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• W4283120741 abstract "Gene transcription by RNA polymerase II (RNAPol II) is a tightly regulated process in the genomic, temporal, and spatial context. Recently, we have shown that chromatin exhibits spatially coherently moving regions over the entire nucleus, which is enhanced by transcription. Yet, it remains unclear how the mobility of RNA Pol II molecules is affected by transcription regulation and whether this response depends on the coordinated chromatin movement. We applied our Dense Flow reConstruction and Correlation method to analyze nucleus-wide coherent movements of RNA Pol II in living human cancer cells. We observe a spatially coherent movement of RNA Pol II molecules over ≈1 μm, which depends on transcriptional activity. Inducing transcription in quiescent cells decreased the coherent motion of RNA Pol II. We then quantify the spatial correlation length of RNA Pol II in the context of DNA motion. RNA Pol II and chromatin spatially coherent motions respond oppositely to transcriptional activities. Our study holds the potential of studying the chromatin environment in different nuclear processes." @default.
• W4283120741 created "2022-06-20" @default.
• W4283120741 creator A5038281692 @default.
• W4283120741 creator A5038799909 @default.
• W4283120741 date "2022-06-19" @default.
• W4283120741 modified "2023-10-14" @default.
• W4283120741 title "Spatially coherent diffusion of human RNA Pol II depends on transcriptional state rather than chromatin motion" @default.
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• W4283120741 doi "https://doi.org/10.1080/19491034.2022.2088988" @default.
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