Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283158668> ?p ?o ?g. }
- W4283158668 abstract "Abstract Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its microenvironment using genetically engineered mice, recombinant constructs, pharmacologic agonists and antagonists. We observe that manipulating the EphB4 intracellular domain on cancer cells accelerates tumor growth and angiogenesis. EphB4 cancer cell loss also triggers compensatory upregulation of EphA4 and T regulatory cells (Tregs) influx and their targeting results in reversal of accelerated tumor growth mediated by EphB4 knockdown. EphrinB2 knockout on cancer cells and vasculature, on the other hand, results in maximal tumor reduction and vascular normalization. We report that EphB4 agonism provides no additional anti-tumoral benefit in the absence of ephrinB2. These results identify ephrinB2 as a tumor promoter and its receptor, EphB4, as a tumor suppressor in HNSCC, presenting opportunities for rational drug design." @default.
- W4283158668 created "2022-06-21" @default.
- W4283158668 creator A5006524743 @default.
- W4283158668 creator A5009011339 @default.
- W4283158668 creator A5020728231 @default.
- W4283158668 creator A5022796313 @default.
- W4283158668 creator A5023517196 @default.
- W4283158668 creator A5024508176 @default.
- W4283158668 creator A5025056006 @default.
- W4283158668 creator A5028336152 @default.
- W4283158668 creator A5034675773 @default.
- W4283158668 creator A5043672102 @default.
- W4283158668 creator A5049909598 @default.
- W4283158668 creator A5053734974 @default.
- W4283158668 creator A5057844697 @default.
- W4283158668 creator A5058978735 @default.
- W4283158668 creator A5062068191 @default.
- W4283158668 creator A5062814410 @default.
- W4283158668 creator A5065901734 @default.
- W4283158668 creator A5066040148 @default.
- W4283158668 creator A5069782695 @default.
- W4283158668 creator A5071813788 @default.
- W4283158668 creator A5083658045 @default.
- W4283158668 creator A5086074491 @default.
- W4283158668 creator A5087152142 @default.
- W4283158668 date "2022-06-20" @default.
- W4283158668 modified "2023-10-18" @default.
- W4283158668 title "EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment" @default.
- W4283158668 cites W1498397332 @default.
- W4283158668 cites W1522211409 @default.
- W4283158668 cites W1644992952 @default.
- W4283158668 cites W1812170084 @default.
- W4283158668 cites W1970939449 @default.
- W4283158668 cites W1974195547 @default.
- W4283158668 cites W1978521234 @default.
- W4283158668 cites W1980819464 @default.
- W4283158668 cites W1987263161 @default.
- W4283158668 cites W1992112921 @default.
- W4283158668 cites W1992187858 @default.
- W4283158668 cites W1997670728 @default.
- W4283158668 cites W2001954506 @default.
- W4283158668 cites W2005157049 @default.
- W4283158668 cites W2016472530 @default.
- W4283158668 cites W2021405662 @default.
- W4283158668 cites W2021476941 @default.
- W4283158668 cites W2038385234 @default.
- W4283158668 cites W2043508733 @default.
- W4283158668 cites W2059787923 @default.
- W4283158668 cites W2064610855 @default.
- W4283158668 cites W2071002343 @default.
- W4283158668 cites W2081916555 @default.
- W4283158668 cites W2085057999 @default.
- W4283158668 cites W2094330253 @default.
- W4283158668 cites W2094354431 @default.
- W4283158668 cites W2096653911 @default.
- W4283158668 cites W2099126984 @default.
- W4283158668 cites W2100382285 @default.
- W4283158668 cites W2108212727 @default.
- W4283158668 cites W2137571589 @default.
- W4283158668 cites W2144205331 @default.
- W4283158668 cites W2148894060 @default.
- W4283158668 cites W2162542545 @default.
- W4283158668 cites W2166780735 @default.
- W4283158668 cites W2168086106 @default.
- W4283158668 cites W2170506825 @default.
- W4283158668 cites W2216468827 @default.
- W4283158668 cites W2314550121 @default.
- W4283158668 cites W2315367769 @default.
- W4283158668 cites W2472469504 @default.
- W4283158668 cites W2523928754 @default.
- W4283158668 cites W2529484692 @default.
- W4283158668 cites W2567598337 @default.
- W4283158668 cites W2612370573 @default.
- W4283158668 cites W2655262992 @default.
- W4283158668 cites W2681853310 @default.
- W4283158668 cites W2744811451 @default.
- W4283158668 cites W2771542157 @default.
- W4283158668 cites W2786753426 @default.
- W4283158668 cites W2796153844 @default.
- W4283158668 cites W2796637672 @default.
- W4283158668 cites W2807422997 @default.
- W4283158668 cites W2883947220 @default.
- W4283158668 cites W2893742037 @default.
- W4283158668 cites W2897460617 @default.
- W4283158668 cites W2905644126 @default.
- W4283158668 cites W2922663706 @default.
- W4283158668 cites W2948510422 @default.
- W4283158668 cites W2964256876 @default.
- W4283158668 cites W2986633517 @default.
- W4283158668 cites W2997652717 @default.
- W4283158668 cites W3004283117 @default.
- W4283158668 cites W3014485181 @default.
- W4283158668 cites W3026809871 @default.
- W4283158668 cites W3084031428 @default.
- W4283158668 cites W3152586353 @default.
- W4283158668 cites W45031843 @default.
- W4283158668 doi "https://doi.org/10.1038/s41467-022-31124-7" @default.
- W4283158668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35725568" @default.
- W4283158668 hasPublicationYear "2022" @default.
- W4283158668 type Work @default.