FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283158882> ?p ?o ?g. }

• W4283158882 endingPage "290" @default.
• W4283158882 startingPage "282" @default.
• W4283158882 abstract "High-quality evidence for whether the use of renin-angiotensin-aldosterone system (RAAS) inhibitors worsens clinical outcomes for patients with coronavirus disease 2019 (COVID-19) is lacking. The present study aimed to evaluate the effect of RAAS inhibitors on disease severity and mortality in patients with hypertension and COVID-19 using randomized controlled trials (RCTs) and propensity score-matched (PSM) studies.A literature search was conducted with PubMed, Embase, and Scopus databases from 31 December 2019 to 10 January 2022. We included RCTs and PSM studies comparing the risk of severe illness or mortality in patients with hypertension and COVID-19 treated or not treated with RAAS inhibitors. Individual trial data were combined to estimate the pooled odds ratio (OR) with a random-effects model.A total of 17 studies (4 RCTs and 13 PSM studies) were included in the meta-analysis. The use of RAAS inhibitors was not associated with an increased risk of severe illness (OR=1.00, 95% confidence interval [CI]: 0.88-1.14, I2=28%) or mortality (OR=0.96, 95% CI: 0.83-1.11, I2=16%) for patients with hypertension and COVID-19. Furthermore, there was no significant difference in the severity of COVID-19 when patients continued or discontinued treatment with RAAS inhibitors (OR=1.01, 95% CI: 0.78-1.29, I2=0%).This study suggests that there was no association between treatment with RAAS inhibitors and worsened COVID-19 disease outcomes. Our findings support the current guidelines that RAAS inhibitors should be continued in the setting of the COVID-19 pandemic. However, the benefit of RAAS inhibitor medications for COVID-19 patients should be further validated with more RCTs." @default.
• W4283158882 created "2022-06-21" @default.
• W4283158882 creator A5003850660 @default.
• W4283158882 creator A5007442778 @default.
• W4283158882 creator A5022911304 @default.
• W4283158882 creator A5023804064 @default.
• W4283158882 creator A5049268355 @default.
• W4283158882 creator A5058985073 @default.
• W4283158882 creator A5068461836 @default.
• W4283158882 creator A5090400552 @default.
• W4283158882 date "2022-10-01" @default.
• W4283158882 modified "2023-10-18" @default.
• W4283158882 title "The effect of renin–angiotensin–aldosterone system inhibitors in patients with hypertension and COVID-19: A meta-analysis of randomized controlled trials and propensity score-matched studies" @default.
• W4283158882 cites W110935427 @default.
• W4283158882 cites W2084917404 @default.
• W4283158882 cites W2098923148 @default.
• W4283158882 cites W2125435699 @default.
• W4283158882 cites W2144168223 @default.
• W4283158882 cites W2162409127 @default.
• W4283158882 cites W2427094903 @default.
• W4283158882 cites W2588681363 @default.
• W4283158882 cites W3004280078 @default.
• W4283158882 cites W3008827533 @default.
• W4283158882 cites W3010126769 @default.
• W4283158882 cites W3010580363 @default.
• W4283158882 cites W3011862945 @default.
• W4283158882 cites W3012184818 @default.
• W4283158882 cites W3013302817 @default.
• W4283158882 cites W3016505858 @default.
• W4283158882 cites W3016572296 @default.
• W4283158882 cites W3017545174 @default.
• W4283158882 cites W3021992825 @default.
• W4283158882 cites W3023640683 @default.
• W4283158882 cites W3023751598 @default.
• W4283158882 cites W3032939692 @default.
• W4283158882 cites W3034312608 @default.
• W4283158882 cites W3035011439 @default.
• W4283158882 cites W3037521489 @default.
• W4283158882 cites W3040801404 @default.
• W4283158882 cites W3041264248 @default.
• W4283158882 cites W3048086118 @default.
• W4283158882 cites W3048657604 @default.
• W4283158882 cites W3082265583 @default.
• W4283158882 cites W3095972676 @default.
• W4283158882 cites W3112200073 @default.
• W4283158882 cites W3116055094 @default.
• W4283158882 cites W3118396415 @default.
• W4283158882 cites W3118615836 @default.
• W4283158882 cites W3122900688 @default.
• W4283158882 cites W3133980439 @default.
• W4283158882 cites W3138085488 @default.
• W4283158882 cites W3141893624 @default.
• W4283158882 cites W3155524240 @default.
• W4283158882 cites W3157778274 @default.
• W4283158882 cites W3160332462 @default.
• W4283158882 cites W3160831353 @default.
• W4283158882 cites W3169034632 @default.
• W4283158882 cites W3181426520 @default.
• W4283158882 cites W4205277722 @default.
• W4283158882 doi "https://doi.org/10.1016/j.jointm.2022.05.004" @default.
• W4283158882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36785646" @default.
• W4283158882 hasPublicationYear "2022" @default.
• W4283158882 type Work @default.
• W4283158882 citedByCount "1" @default.
• W4283158882 countsByYear W42831588822023 @default.
• W4283158882 crossrefType "journal-article" @default.
• W4283158882 hasAuthorship W4283158882A5003850660 @default.
• W4283158882 hasAuthorship W4283158882A5007442778 @default.
• W4283158882 hasAuthorship W4283158882A5022911304 @default.
• W4283158882 hasAuthorship W4283158882A5023804064 @default.
• W4283158882 hasAuthorship W4283158882A5049268355 @default.
• W4283158882 hasAuthorship W4283158882A5058985073 @default.
• W4283158882 hasAuthorship W4283158882A5068461836 @default.
• W4283158882 hasAuthorship W4283158882A5090400552 @default.
• W4283158882 hasBestOaLocation W42831588822 @default.
• W4283158882 hasConcept C126322002 @default.
• W4283158882 hasConcept C156957248 @default.
• W4283158882 hasConcept C168563851 @default.
• W4283158882 hasConcept C17923572 @default.
• W4283158882 hasConcept C44249647 @default.
• W4283158882 hasConcept C71924100 @default.
• W4283158882 hasConcept C95190672 @default.
• W4283158882 hasConceptScore W4283158882C126322002 @default.
• W4283158882 hasConceptScore W4283158882C156957248 @default.
• W4283158882 hasConceptScore W4283158882C168563851 @default.
• W4283158882 hasConceptScore W4283158882C17923572 @default.
• W4283158882 hasConceptScore W4283158882C44249647 @default.
• W4283158882 hasConceptScore W4283158882C71924100 @default.
• W4283158882 hasConceptScore W4283158882C95190672 @default.
• W4283158882 hasFunder F4320321001 @default.
• W4283158882 hasFunder F4320336309 @default.
• W4283158882 hasIssue "4" @default.
• W4283158882 hasLocation W42831588821 @default.
• W4283158882 hasLocation W42831588822 @default.
• W4283158882 hasLocation W42831588823 @default.
• W4283158882 hasOpenAccess W4283158882 @default.
• W4283158882 hasPrimaryLocation W42831588821 @default.
• W4283158882 hasRelatedWork W2047252483 @default.

• next