FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283162217> ?p ?o ?g. }

• W4283162217 endingPage "2762" @default.
• W4283162217 startingPage "2753" @default.
• W4283162217 abstract "Prostate cancer ranks among the most commonly diagnosed malignancies for men and has become a non-negligible threat for public health. Interplay between inflammatory factors and cancer cells renders inflammatory tissue environment as a predisposing condition for cancer development. The Hippo pathway is a conserved signaling pathway across multiple species during evolution that regulates tissue homeostasis and organ development. Nevertheless, whether Hippo pathway regulates cancer-related inflammatory factors remains elusive. Here, we show that high cell density-mediated activation of the Hippo pathway blunts STAT3 activity in prostate cancer cells. Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation. Expression of a nonphosphorylatable STAT3 T622A mutant enhances STAT3 activity and IL6 expression at high cell density and promotes tumor growth in a mice xenograft model. Our findings demonstrate that STAT3 is a novel phosphorylation substrate for MST2 and thereby highlight a regulatory cascade underlying the crosstalk between inflammation and the Hippo pathway in prostate cancer cells." @default.
• W4283162217 created "2022-06-21" @default.
• W4283162217 creator A5019114519 @default.
• W4283162217 creator A5031513961 @default.
• W4283162217 creator A5036111618 @default.
• W4283162217 creator A5037652994 @default.
• W4283162217 creator A5039348177 @default.
• W4283162217 creator A5047957070 @default.
• W4283162217 creator A5065018805 @default.
• W4283162217 creator A5072128366 @default.
• W4283162217 creator A5073629267 @default.
• W4283162217 creator A5077045828 @default.
• W4283162217 date "2022-06-28" @default.
• W4283162217 modified "2023-10-01" @default.
• W4283162217 title "Hippo pathway monomerizes <scp>STAT3</scp> to regulate prostate cancer growth" @default.
• W4283162217 cites W1606529485 @default.
• W4283162217 cites W1996690536 @default.
• W4283162217 cites W2004480757 @default.
• W4283162217 cites W2011121500 @default.
• W4283162217 cites W2012223636 @default.
• W4283162217 cites W2015582646 @default.
• W4283162217 cites W2015770887 @default.
• W4283162217 cites W2016670036 @default.
• W4283162217 cites W2028544780 @default.
• W4283162217 cites W2032300746 @default.
• W4283162217 cites W2062640870 @default.
• W4283162217 cites W2099709490 @default.
• W4283162217 cites W2102912734 @default.
• W4283162217 cites W2159945718 @default.
• W4283162217 cites W2223413920 @default.
• W4283162217 cites W2292259030 @default.
• W4283162217 cites W2519289960 @default.
• W4283162217 cites W2766960086 @default.
• W4283162217 cites W2786987313 @default.
• W4283162217 cites W2903784703 @default.
• W4283162217 cites W2904492726 @default.
• W4283162217 cites W2906052725 @default.
• W4283162217 cites W2923146595 @default.
• W4283162217 cites W2969166714 @default.
• W4283162217 cites W3087992083 @default.
• W4283162217 cites W3164414550 @default.
• W4283162217 cites W3188326491 @default.
• W4283162217 cites W3197497404 @default.
• W4283162217 cites W3198098339 @default.
• W4283162217 cites W4220910428 @default.
• W4283162217 cites W4283162217 @default.
• W4283162217 doi "https://doi.org/10.1111/cas.15463" @default.
• W4283162217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35722967" @default.
• W4283162217 hasPublicationYear "2022" @default.
• W4283162217 type Work @default.
• W4283162217 citedByCount "5" @default.
• W4283162217 countsByYear W42831622172022 @default.
• W4283162217 countsByYear W42831622172023 @default.
• W4283162217 crossrefType "journal-article" @default.
• W4283162217 hasAuthorship W4283162217A5019114519 @default.
• W4283162217 hasAuthorship W4283162217A5031513961 @default.
• W4283162217 hasAuthorship W4283162217A5036111618 @default.
• W4283162217 hasAuthorship W4283162217A5037652994 @default.
• W4283162217 hasAuthorship W4283162217A5039348177 @default.
• W4283162217 hasAuthorship W4283162217A5047957070 @default.
• W4283162217 hasAuthorship W4283162217A5065018805 @default.
• W4283162217 hasAuthorship W4283162217A5072128366 @default.
• W4283162217 hasAuthorship W4283162217A5073629267 @default.
• W4283162217 hasAuthorship W4283162217A5077045828 @default.
• W4283162217 hasBestOaLocation W42831622171 @default.
• W4283162217 hasConcept C11960822 @default.
• W4283162217 hasConcept C120665830 @default.
• W4283162217 hasConcept C121332964 @default.
• W4283162217 hasConcept C121608353 @default.
• W4283162217 hasConcept C169822122 @default.
• W4283162217 hasConcept C172512520 @default.
• W4283162217 hasConcept C2778923194 @default.
• W4283162217 hasConcept C2780192828 @default.
• W4283162217 hasConcept C502942594 @default.
• W4283162217 hasConcept C54355233 @default.
• W4283162217 hasConcept C62478195 @default.
• W4283162217 hasConcept C86803240 @default.
• W4283162217 hasConcept C95444343 @default.
• W4283162217 hasConceptScore W4283162217C11960822 @default.
• W4283162217 hasConceptScore W4283162217C120665830 @default.
• W4283162217 hasConceptScore W4283162217C121332964 @default.
• W4283162217 hasConceptScore W4283162217C121608353 @default.
• W4283162217 hasConceptScore W4283162217C169822122 @default.
• W4283162217 hasConceptScore W4283162217C172512520 @default.
• W4283162217 hasConceptScore W4283162217C2778923194 @default.
• W4283162217 hasConceptScore W4283162217C2780192828 @default.
• W4283162217 hasConceptScore W4283162217C502942594 @default.
• W4283162217 hasConceptScore W4283162217C54355233 @default.
• W4283162217 hasConceptScore W4283162217C62478195 @default.
• W4283162217 hasConceptScore W4283162217C86803240 @default.
• W4283162217 hasConceptScore W4283162217C95444343 @default.
• W4283162217 hasIssue "8" @default.
• W4283162217 hasLocation W42831622171 @default.
• W4283162217 hasLocation W42831622172 @default.
• W4283162217 hasLocation W42831622173 @default.
• W4283162217 hasOpenAccess W4283162217 @default.
• W4283162217 hasPrimaryLocation W42831622171 @default.
• W4283162217 hasRelatedWork W1551086083 @default.

• next