FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283163651> ?p ?o ?g. }

• W4283163651 endingPage "112650" @default.
• W4283163651 startingPage "112650" @default.
• W4283163651 abstract "Calcium phosphate cement (CPC) is a self-setting, biocompatible and osteoconductive bone cement, however its use as a bone substitute is still limited owing to its low bioactivity (i.e. its slow in vivo resorption and slow new bone formation rate) which is a challenging issue to be addressed. Herein, we report for the first time highly bioactive bone cement microspheres formulated from a cement paste containing α-tricalcium phosphate microparticles (α-TCP) and mesoporous calcium silicate bioactive glass nanoparticles (mesoporous BGn) using a water-in-oil emulsion method. Indeed, bioactive microspheres possess high potential as bone defect fillers for bone regeneration. The α-TCP microparticles were prepared by a solid state synthesis at 1400 ºC while mesoporous BGn were synthesized by template-assissted ultrasound-mediated sol-gel method. The particle size distribution of as-prepared cement microspheres was in the range of 200 – 450 µm with a sphericity index in the range of 0.92 – 0.94. The surface morphology of α-TCP microspheres revealed α-TCP micoparticles with smooth surfaces whereas α-TCP/BGn microspheres unveiled nano-roughened α-TCP microparticles. The as-prepared α-TCP/BGn cement microspheres exhibited larger specific surface area ca 18.6 m2/g, sustained release of soluble silicate (SiO44-) ions (118 ppm within a week) and high protein adsorption capacity (252 mg/g). Notably, the α-TCP/BGn cement microspheres showed excellent in vitro surface bioactivity via formation of massive amounts of bone-like hydroxyapatite spherules and aggregates on their surfaces after soaking in simulated body fluid. Importantly, the in vivo implantation of as-prepared α-TCP/BGn cement microspheres in rat calvarial critical size bone defects for 6 weeks unveiled high in vivo bioactivity in terms of substantial new bone ingrowth and significant new bone formation within the bone defect as evidenced by histological analyses, X-ray radiography and micro-computed tomography evaluations." @default.
• W4283163651 created "2022-06-21" @default.
• W4283163651 creator A5014129887 @default.
• W4283163651 creator A5017695509 @default.
• W4283163651 creator A5079743362 @default.
• W4283163651 date "2022-09-01" @default.
• W4283163651 modified "2023-09-30" @default.
• W4283163651 title "Highly bioactive bone cement microspheres based on α-tricalcium phosphate microparticles/mesoporous bioactive glass nanoparticles: Formulation, physico-chemical characterization and in vivo bone regeneration" @default.
• W4283163651 cites W1808616664 @default.
• W4283163651 cites W1938355900 @default.
• W4283163651 cites W1965362567 @default.
• W4283163651 cites W1983114289 @default.
• W4283163651 cites W1987138931 @default.
• W4283163651 cites W1993154983 @default.
• W4283163651 cites W1996760356 @default.
• W4283163651 cites W2012655169 @default.
• W4283163651 cites W2012682158 @default.
• W4283163651 cites W2023653387 @default.
• W4283163651 cites W2034653161 @default.
• W4283163651 cites W2041226774 @default.
• W4283163651 cites W2046941824 @default.
• W4283163651 cites W2060286759 @default.
• W4283163651 cites W2063720301 @default.
• W4283163651 cites W2079059815 @default.
• W4283163651 cites W2081749508 @default.
• W4283163651 cites W2087660529 @default.
• W4283163651 cites W2121197837 @default.
• W4283163651 cites W2154271696 @default.
• W4283163651 cites W2154972211 @default.
• W4283163651 cites W2166286451 @default.
• W4283163651 cites W2167172746 @default.
• W4283163651 cites W2167486527 @default.
• W4283163651 cites W2213772184 @default.
• W4283163651 cites W2309703227 @default.
• W4283163651 cites W2320682445 @default.
• W4283163651 cites W2559768247 @default.
• W4283163651 cites W2583131078 @default.
• W4283163651 cites W2614129732 @default.
• W4283163651 cites W2623560265 @default.
• W4283163651 cites W2737516629 @default.
• W4283163651 cites W2738451459 @default.
• W4283163651 cites W2777648965 @default.
• W4283163651 cites W2806879035 @default.
• W4283163651 cites W2916678483 @default.
• W4283163651 cites W2929373958 @default.
• W4283163651 cites W2943026941 @default.
• W4283163651 cites W2945362067 @default.
• W4283163651 cites W2946231418 @default.
• W4283163651 cites W2956031189 @default.
• W4283163651 cites W3008340151 @default.
• W4283163651 cites W3011880195 @default.
• W4283163651 cites W3016894211 @default.
• W4283163651 cites W3021276446 @default.
• W4283163651 cites W3049154243 @default.
• W4283163651 cites W3089277659 @default.
• W4283163651 cites W3092952365 @default.
• W4283163651 cites W3157594805 @default.
• W4283163651 cites W3179639795 @default.
• W4283163651 cites W3182999508 @default.
• W4283163651 cites W3186542844 @default.
• W4283163651 cites W3207897682 @default.
• W4283163651 cites W4206750457 @default.
• W4283163651 cites W4224272149 @default.
• W4283163651 doi "https://doi.org/10.1016/j.colsurfb.2022.112650" @default.
• W4283163651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35763895" @default.
• W4283163651 hasPublicationYear "2022" @default.
• W4283163651 type Work @default.
• W4283163651 citedByCount "6" @default.
• W4283163651 countsByYear W42831636512022 @default.
• W4283163651 countsByYear W42831636512023 @default.
• W4283163651 crossrefType "journal-article" @default.
• W4283163651 hasAuthorship W4283163651A5014129887 @default.
• W4283163651 hasAuthorship W4283163651A5017695509 @default.
• W4283163651 hasAuthorship W4283163651A5079743362 @default.
• W4283163651 hasConcept C114874019 @default.
• W4283163651 hasConcept C127413603 @default.
• W4283163651 hasConcept C155672457 @default.
• W4283163651 hasConcept C159985019 @default.
• W4283163651 hasConcept C161790260 @default.
• W4283163651 hasConcept C171250308 @default.
• W4283163651 hasConcept C178790620 @default.
• W4283163651 hasConcept C185592680 @default.
• W4283163651 hasConcept C187530423 @default.
• W4283163651 hasConcept C192562407 @default.
• W4283163651 hasConcept C26771246 @default.
• W4283163651 hasConcept C2778519171 @default.
• W4283163651 hasConcept C2780300285 @default.
• W4283163651 hasConcept C42360764 @default.
• W4283163651 hasConcept C523993062 @default.
• W4283163651 hasConcept C82776694 @default.
• W4283163651 hasConceptScore W4283163651C114874019 @default.
• W4283163651 hasConceptScore W4283163651C127413603 @default.
• W4283163651 hasConceptScore W4283163651C155672457 @default.
• W4283163651 hasConceptScore W4283163651C159985019 @default.
• W4283163651 hasConceptScore W4283163651C161790260 @default.
• W4283163651 hasConceptScore W4283163651C171250308 @default.
• W4283163651 hasConceptScore W4283163651C178790620 @default.
• W4283163651 hasConceptScore W4283163651C185592680 @default.

• next