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• W4283166189 abstract "MS: MSA new study finds that screening mammography is less likely to detect breast cancer in women with multiple sclerosis (MS) than female patients without the disease. Noting in Neurology that the MS population's survival from breast cancer and colorectal cancer is “compromised,” researchers pointed out that cancer screening and timely diagnoses affect cancer survival and have not previously been studied in the MS cancer population (2022; https://doi.org/10.1212/WNL.0000000000200163). With their investigation, the authors sought to determine whether the diagnostic route, cancer stage, or diagnostic interval differed in patients having cancer with and without multiple sclerosis. To achieve that end, the researchers conducted a matched population-based cross-sectional study of breast cancers (2007-2015) and colorectal cancers (2009-2012) in patients with MS. Exclusion criteria included second or concurrent primary cancers, no health care coverage and, for the patients without MS, those with any demyelinating disease. The researchers based 1:4 matching of MS to non-MS on birth year, sex (colorectal only), postal code, and cancer diagnosis year (breast only). Cancer outcomes were diagnostic route (screen-detected vs. symptomatic), stage (Stage I vs. all others), and diagnostic interval (time from first presentation to diagnosis). Multivariable regression analyses controlled for age, sex (colorectal only), diagnosis year, income quintile, urban/rural residence, and comorbidity. The researchers looked at data from 351 patients with both MS and breast cancer, 1,404 matched patients with breast cancer without MS, 54 patients with MS and colorectal cancer, and 216 matched patients with colorectal cancer without MS. Overall, the team found that MS was linked to fewer screen-detected cancers in breast cancer, with an odds ratio of 0.68, and possibly colorectal cancer with an odds ratio of 0.52. In addition, the researchers determined there was no connection between differences in breast cancer stage at diagnosis, with an odds ratio of 0.81 for Stage I cancer. They also discovered, however, that MS was associated with greater odds of Stage I colorectal cancer with an odds ratio of 2.11. Screening mammography detected breast cancer in MS patients nearly 30 percent of the time, while screening mammography detected breast cancer in patients without MS more than 37 percent of the time. In addition, the median length of the diagnostic interval did not vary between patients with and without MS in either cancer cohort, according to authors, who noted that the median interval in breast cancer patients who also had MS was 35 days versus the interval of 34 days in patients who do not have multiple sclerosis. “Survival after breast and colorectal cancer is worse in people with MS than without MS,” noted study co-author Ruth Ann Marrie, MD, PhD, FRCPC, FCAHS, Professor of Medicine and Community Health Sciences at the Max Rady College of Medicine of the Rady Faculty of Health Sciences at the University of Manitoba. “We know that cancer screening helps with early detection and timely diagnosis, and that this in turn affects survival,” she said. “So, we wanted to assess whether screen detection of cancer was lower in people with MS and whether diagnostic delays were longer.” With this in mind, Marrie and colleagues hypothesized that the MS population would have lower screen detection rates, longer diagnostic intervals, and higher stage at diagnosis of breast and colorectal cancers than a matched population with MS. “We can only speculate, but our findings suggest that disability may play some role” in these lower screen detection rates,” Marrie noted. “Prior studies have suggested that greater mobility impairment is associated with lower rates of mammography and screening colonoscopies. Physical impairments may create physical access barriers to getting these tests. There may also be competing standards on primary care physicians' time [due to MS] that lead to less screening.” In terms of how these findings could help imaging and care teams understand and approach the detection and subsequent treatment of cancer in female patients with MS, “more work is needed to understand cancer care pathways in MS, including those related to screening and early detection,” Marrie said. “Attention to the importance of prevention health care in the MS population is also needed.” Mark McGraw is a contributing writer. More Breast Cancer Research Explore more breast cancer clinical studies and new treatments online at https://bit.ly/393YElg." @default.
• W4283166189 created "2022-06-21" @default.
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• W4283166189 date "2022-06-20" @default.
• W4283166189 modified "2023-10-18" @default.
• W4283166189 title "Lower Screening Rates for Women Who Have Breast Cancer Along With MS" @default.
• W4283166189 doi "https://doi.org/10.1097/01.cot.0000839964.75463.62" @default.
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