FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283166767> ?p ?o ?g. }

• W4283166767 abstract "Necroptosis, a form of programmed cell death, is increasingly being investigated for its controversial role in tumorigenesis and progression. Necroptosis suppresses tumor formation and tumor development by killing tumor cells; however, the necrotic cells also promote tumor formation and tumor development via the immunosuppressive effect of necroptosis and inflammatory response caused by cytokine release. Thus, the exact mechanism of necroptosis in pan-cancer remains unknown.The data of 11,057 cancer samples were downloaded from the TCGA database, along with clinical information, tumor mutation burden, and microsatellite instability information of the corresponding patients. We used the TCGA data in a pan-cancer analysis to identify differences in mRNA level as well as single nucleotide variants, copy number variants, methylation profiles, and genomic signatures of miRNA-mRNA interactions. Two drug datasets (from GDSC, CTRP) were used to evaluate drug sensitivity and resistance against necroptosis genes.Necroptosis genes were aberrantly expressed in various cancers. The frequency of necroptosis gene mutations was highest in lung squamous cell carcinoma. Furthermore, the correlation between necroptosis gene expression in the tumor microenvironment and immune cell infiltration varied for different cancers. High necroptosis gene expression was found to correlate with NK, Tfh, Th1, CD8_T, and DC cells. These can therefore be used as biomarkers to predict prognosis. By matching gene targets with drugs, we identified potential candidate drugs.Our study showed the genomic alterations and clinical features of necroptosis genes in 33 cancers. This may help clarify the link between necroptosis and tumorigenesis. Our findings may also provide new approaches for the clinical treatment of cancer." @default.
• W4283166767 created "2022-06-21" @default.
• W4283166767 creator A5002543907 @default.
• W4283166767 creator A5020396885 @default.
• W4283166767 creator A5041968534 @default.
• W4283166767 creator A5044301848 @default.
• W4283166767 creator A5047589413 @default.
• W4283166767 creator A5054878819 @default.
• W4283166767 creator A5055207211 @default.
• W4283166767 creator A5057994349 @default.
• W4283166767 creator A5061677247 @default.
• W4283166767 creator A5074082072 @default.
• W4283166767 creator A5075523709 @default.
• W4283166767 creator A5080412453 @default.
• W4283166767 creator A5084108418 @default.
• W4283166767 creator A5084227770 @default.
• W4283166767 creator A5090730101 @default.
• W4283166767 date "2022-06-20" @default.
• W4283166767 modified "2023-09-27" @default.
• W4283166767 title "Clinical Implications of Necroptosis Genes Expression for Cancer Immunity and Prognosis: A Pan-Cancer Analysis" @default.
• W4283166767 cites W1926108284 @default.
• W4283166767 cites W2010522003 @default.
• W4283166767 cites W2020611733 @default.
• W4283166767 cites W2089148552 @default.
• W4283166767 cites W2092503047 @default.
• W4283166767 cites W2120976214 @default.
• W4283166767 cites W2133223863 @default.
• W4283166767 cites W2138632775 @default.
• W4283166767 cites W2146810078 @default.
• W4283166767 cites W2152061559 @default.
• W4283166767 cites W2171787842 @default.
• W4283166767 cites W2315116359 @default.
• W4283166767 cites W2480295405 @default.
• W4283166767 cites W2747383311 @default.
• W4283166767 cites W2791222736 @default.
• W4283166767 cites W2808356595 @default.
• W4283166767 cites W2809972762 @default.
• W4283166767 cites W2883399815 @default.
• W4283166767 cites W2889857177 @default.
• W4283166767 cites W2918522310 @default.
• W4283166767 cites W2922922277 @default.
• W4283166767 cites W2962206784 @default.
• W4283166767 cites W2982858973 @default.
• W4283166767 cites W2984392676 @default.
• W4283166767 cites W2987328290 @default.
• W4283166767 cites W3024821541 @default.
• W4283166767 cites W3090395045 @default.
• W4283166767 cites W3109579509 @default.
• W4283166767 cites W3133999006 @default.
• W4283166767 cites W3137413217 @default.
• W4283166767 cites W3154382139 @default.
• W4283166767 cites W3159353066 @default.
• W4283166767 cites W3163240916 @default.
• W4283166767 cites W3185755985 @default.
• W4283166767 cites W3199243510 @default.
• W4283166767 cites W3204024241 @default.
• W4283166767 cites W3209707812 @default.
• W4283166767 cites W4206778743 @default.
• W4283166767 cites W4206897947 @default.
• W4283166767 cites W4210405686 @default.
• W4283166767 cites W4210651250 @default.
• W4283166767 cites W42372378 @default.
• W4283166767 doi "https://doi.org/10.3389/fimmu.2022.882216" @default.
• W4283166767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35795676" @default.
• W4283166767 hasPublicationYear "2022" @default.
• W4283166767 type Work @default.
• W4283166767 citedByCount "1" @default.
• W4283166767 countsByYear W42831667672023 @default.
• W4283166767 crossrefType "journal-article" @default.
• W4283166767 hasAuthorship W4283166767A5002543907 @default.
• W4283166767 hasAuthorship W4283166767A5020396885 @default.
• W4283166767 hasAuthorship W4283166767A5041968534 @default.
• W4283166767 hasAuthorship W4283166767A5044301848 @default.
• W4283166767 hasAuthorship W4283166767A5047589413 @default.
• W4283166767 hasAuthorship W4283166767A5054878819 @default.
• W4283166767 hasAuthorship W4283166767A5055207211 @default.
• W4283166767 hasAuthorship W4283166767A5057994349 @default.
• W4283166767 hasAuthorship W4283166767A5061677247 @default.
• W4283166767 hasAuthorship W4283166767A5074082072 @default.
• W4283166767 hasAuthorship W4283166767A5075523709 @default.
• W4283166767 hasAuthorship W4283166767A5080412453 @default.
• W4283166767 hasAuthorship W4283166767A5084108418 @default.
• W4283166767 hasAuthorship W4283166767A5084227770 @default.
• W4283166767 hasAuthorship W4283166767A5090730101 @default.
• W4283166767 hasBestOaLocation W42831667671 @default.
• W4283166767 hasConcept C121608353 @default.
• W4283166767 hasConcept C190283241 @default.
• W4283166767 hasConcept C203014093 @default.
• W4283166767 hasConcept C2776107976 @default.
• W4283166767 hasConcept C2779256057 @default.
• W4283166767 hasConcept C31573885 @default.
• W4283166767 hasConcept C502942594 @default.
• W4283166767 hasConcept C54355233 @default.
• W4283166767 hasConcept C555283112 @default.
• W4283166767 hasConcept C86803240 @default.
• W4283166767 hasConcept C8891405 @default.
• W4283166767 hasConcept C94030615 @default.
• W4283166767 hasConcept C96232424 @default.
• W4283166767 hasConceptScore W4283166767C121608353 @default.
• W4283166767 hasConceptScore W4283166767C190283241 @default.

• next