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- W4283166778 abstract "TYPE: Case Report TOPIC: Pharmacotherapeutics INTRODUCTION: Amiodarone is commonly used drug with multiple toxicities. Likelihood of developing amiodarone-toxicity depends on multiple factors including dose and duration. We report a case of amiodarone-induced pulmonary toxicity which occurred within 3 weeks and was nearly missed amidst COVID-19 pandemic based on ground-glass opacities on imaging. CASE PRESENTATION: An 89-year-old male with history of heart failure and atrial fibrillation who was recently discharged after being treated for COVID-19 pneumonia and CHF exacerbation presented again with similar complaints of shortness of breath. His labs revealed elevated inflammatory markers and CT chest showed diffuse ground-glass opacities. Despite being tested negative for COVID-19 pneumonia, there remained a suspicion of the same, until amiodarone was identified as the likely culprit and was discontinued. Steroids were then initiated following which his symptoms gradually improved. DISCUSSION: Multiple factors including age, duration, daily dose, cumulative dose, and pre-existing pulmonary disease are associated with increased risk of amiodarone-induced pulmonary toxicity. Previous studies have reported association of lung toxicity with daily dose of 400 mg or more. This patient was on daily amiodarone dose of 200 mg and developed multifocal consolidative changes with bilateral pleural effusions within 3-4 weeks compared to CT chest from another facility. CONCLUSIONS: Amiodarone has significant adverse effect profile which includes potentially life-threatening pulmonary toxicity, that can occur at a very low dose and sooner than expected. Clinicians should keep high suspicion, especially in elderly patients like one reported here, who develop pulmonary symptoms within weeks of low dose amiodarone initiation, after other common causes have been ruled out. DISCLOSURE: Nothing to declare. KEYWORD: amiodarone toxicity" @default.
- W4283166778 created "2022-06-21" @default.
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- W4283166778 date "2022-06-01" @default.
- W4283166778 modified "2023-10-16" @default.
- W4283166778 title "GROUND GLASS LUNG OPACITIES AMIDST COVID-19 PANDEMIC: A CASE OF EARLY MANIFESTATION OF AMIODARONE-INDUCED PULMONARY TOXICITY" @default.
- W4283166778 doi "https://doi.org/10.1016/j.chest.2021.12.430" @default.
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