Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283167351> ?p ?o ?g. }
- W4283167351 endingPage "1320" @default.
- W4283167351 startingPage "1310" @default.
- W4283167351 abstract "Abstract Isocitrate dehydrogenase ( IDH ) 1/2 mutations are the most frequent druggable alterations in intrahepatic cholangiocarcinoma (iCCA), reported in ~20% of cases. Preclinical evidence indicates that these mutations are associated with homologous recombination deficiency (HRD), which could be exploited as a target for platinum chemotherapy (ChT) and PARP inhibitors. However, the role of IDH1/2 mutations as surrogate biomarkers for platinum efficacy is unknown. We conducted a multicenter, propensity score‐matched analysis to investigate the impact of IDH1/2 mutations on progression‐free survival (PFS), overall response rate (ORR) and disease control rate (DCR) in patients with iCCA treated with platinum‐based ChT. An exploratory comparison of complex HRD estimates between IDH1/2 mutated and wild‐type tumors from TCGA was also performed. A total of 120 cases were matched in a 1:1 ratio (60 IDH1/2 mutant and 60 wild‐type). No differences were observed for platinum‐based PFS (7.7 vs 7.3 months, P = .970), DCR (66.1% vs 74.1%, P = .361) and ORR (27.8% vs 25.0%, P = .741). IDH1 / 2 mutations showed mutual exclusivity with genomic alterations in ATM , BRCA2 , MST1R , NF1, FGFR2 and CDKN2A/B losses, respectively, with no clear survival and response differences. Among TCGA tumors, IDH1/2 mutated CCA did not show higher HRD compared to wild‐type cases. IDH1/2 mutations are not associated with increased sensitivity to platinum‐based ChT in iCCA patients. Deeper genomic sequencing is needed to elucidate the HRD phenotype in IDH1/2 mutant iCCA and exploit its therapeutic vulnerabilities." @default.
- W4283167351 created "2022-06-21" @default.
- W4283167351 creator A5008187226 @default.
- W4283167351 creator A5009935310 @default.
- W4283167351 creator A5013350485 @default.
- W4283167351 creator A5017608697 @default.
- W4283167351 creator A5019787409 @default.
- W4283167351 creator A5021212136 @default.
- W4283167351 creator A5028650036 @default.
- W4283167351 creator A5030318941 @default.
- W4283167351 creator A5034659601 @default.
- W4283167351 creator A5036615333 @default.
- W4283167351 creator A5041373409 @default.
- W4283167351 creator A5043332769 @default.
- W4283167351 creator A5046301295 @default.
- W4283167351 creator A5049569407 @default.
- W4283167351 creator A5051613962 @default.
- W4283167351 creator A5052747030 @default.
- W4283167351 creator A5053732763 @default.
- W4283167351 creator A5064470324 @default.
- W4283167351 creator A5067276745 @default.
- W4283167351 creator A5071330516 @default.
- W4283167351 creator A5071355244 @default.
- W4283167351 creator A5075464309 @default.
- W4283167351 creator A5079437223 @default.
- W4283167351 creator A5079904438 @default.
- W4283167351 creator A5082066847 @default.
- W4283167351 creator A5086579812 @default.
- W4283167351 creator A5087989451 @default.
- W4283167351 creator A5088550918 @default.
- W4283167351 creator A5090353867 @default.
- W4283167351 creator A5090671983 @default.
- W4283167351 date "2022-07-09" @default.
- W4283167351 modified "2023-10-18" @default.
- W4283167351 title "Platinum sensitivity in patients with <i>IDH1/2</i> mutated vs wild‐type intrahepatic cholangiocarcinoma: A propensity score‐based study" @default.
- W4283167351 cites W2074952360 @default.
- W4283167351 cites W2096796171 @default.
- W4283167351 cites W2106550415 @default.
- W4283167351 cites W2115261608 @default.
- W4283167351 cites W2123696077 @default.
- W4283167351 cites W2124033094 @default.
- W4283167351 cites W2144168223 @default.
- W4283167351 cites W2147629880 @default.
- W4283167351 cites W2149441684 @default.
- W4283167351 cites W2164219809 @default.
- W4283167351 cites W2168409298 @default.
- W4283167351 cites W2295085830 @default.
- W4283167351 cites W2301066876 @default.
- W4283167351 cites W2406250479 @default.
- W4283167351 cites W2520639290 @default.
- W4283167351 cites W2585230893 @default.
- W4283167351 cites W2588147230 @default.
- W4283167351 cites W2745824859 @default.
- W4283167351 cites W2748606465 @default.
- W4283167351 cites W2771217224 @default.
- W4283167351 cites W2781525129 @default.
- W4283167351 cites W2783596779 @default.
- W4283167351 cites W2806800293 @default.
- W4283167351 cites W2896872272 @default.
- W4283167351 cites W2939332654 @default.
- W4283167351 cites W2939577741 @default.
- W4283167351 cites W2947109943 @default.
- W4283167351 cites W2949363897 @default.
- W4283167351 cites W2955082801 @default.
- W4283167351 cites W2958222816 @default.
- W4283167351 cites W2969185256 @default.
- W4283167351 cites W3018583760 @default.
- W4283167351 cites W3019769209 @default.
- W4283167351 cites W3024247862 @default.
- W4283167351 cites W3028410510 @default.
- W4283167351 cites W3028673234 @default.
- W4283167351 cites W3032702320 @default.
- W4283167351 cites W3039485233 @default.
- W4283167351 cites W3095200063 @default.
- W4283167351 cites W3134901434 @default.
- W4283167351 cites W3162010243 @default.
- W4283167351 cites W3166249973 @default.
- W4283167351 cites W3167165685 @default.
- W4283167351 cites W3169360454 @default.
- W4283167351 cites W3182644137 @default.
- W4283167351 cites W3196390718 @default.
- W4283167351 cites W3199253355 @default.
- W4283167351 cites W3214769841 @default.
- W4283167351 cites W4237937003 @default.
- W4283167351 doi "https://doi.org/10.1002/ijc.34182" @default.
- W4283167351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35723131" @default.
- W4283167351 hasPublicationYear "2022" @default.
- W4283167351 type Work @default.
- W4283167351 citedByCount "5" @default.
- W4283167351 countsByYear W42831673512022 @default.
- W4283167351 countsByYear W42831673512023 @default.
- W4283167351 crossrefType "journal-article" @default.
- W4283167351 hasAuthorship W4283167351A5008187226 @default.
- W4283167351 hasAuthorship W4283167351A5009935310 @default.
- W4283167351 hasAuthorship W4283167351A5013350485 @default.
- W4283167351 hasAuthorship W4283167351A5017608697 @default.
- W4283167351 hasAuthorship W4283167351A5019787409 @default.
- W4283167351 hasAuthorship W4283167351A5021212136 @default.