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• W4283168114 abstract "<h3>Introduction</h3> Multichannel channel impedance-pH (MII-pH) monitoring has affiliated PSPW with reflux clearance/restoration of neutral oesophageal pH, which is a novel marker for gastrooesophageal reflux disease (GORD).^1–3 PSPW incidence has not been studied alongside 96-hours of wireless Bravo pH (WBpH) monitoring which this paper will address. <h3>Method</h3> Retrospective study selecting patients from 2010 to 2021 who had normal MII-pH study¹ and were followed-up with WBpH test within 1-year. WBpH test diagnosis was based on 4-day average oesophageal acid exposure.⁴Patients prepared for reflux tests according to national guidelines.⁵ Any patients with major motility disorders were excluded.⁶ Method for measuring PSPW was based on.^{1 2 7} Successful PSPW (sPSPW) was denoted when present and recovering the oesophageal pH to neutral. Failed PSPW (fPSPW) was denoted when absent or failing to neutralise the oesophageal acidic pH. The sPSPW and fPSPW indices were calculated with respect to the total acid reflux episodes and sPSPW/fPSPW ratio was calculated per study. Statistical analysis for sPSPW and fPSPW with respect to WBpH outcome was performed via Pearson correlation, t-test and receiver operating characteristic (ROC) curve with Youden’s index to determine the optimal cut-off values. Positive predictive value (PPV), negative predictive value (NPV), likelihood ratio (LR+) and odd ratio (OR) were computed with respect to the cut-off values. <h3>Results</h3> 130 patients were selected (M:F=35:95, aged=19–79 years) and 38.2% of patients had GORD on WBpH study. Increase in the oesophageal acid exposure on WBpH correlated with diminishing sPSPW incidence (r=0.510, p<0.001) and greater fPSPW prevalence (r=0.522, p<0.001). GORD was found in lower sPSPW index (0.42 vs 0.69, p<0.001) and higher fPSPW index (0.53 vs 0.25, p<0.001). Optimal cut-off values for sPSPW, fPSPW and sPSPW/fPSPW ratio were respectively <0.457, >0.455 and <1 that revealed test outcome and patient outcome (with respect to cut-off values) to exceed 70% (see figure 1). The association to GORD was positive. <h3>Conclusion</h3> PSPW response in negative MII-pH study may justify WBpH referral. <h3>Reference</h3> Gyawali, <i>et al. Gut</i> 2018;<b>67</b>(7):1351–1362. Xu H, <i>et al. J Neurogastroenterol Motil</i>. 2020;<b>26</b>(3):378–383. Rogers, <i>et al. Neurogastroenterol Motil</i>. 2021;<b>33</b>(2):e13973. Rusu, <i>et al. Gut</i>. 2021;<b>70</b>(12):2230–2237. Trudgill, <i>et al. Gut</i>. 2019;<b>68</b>(10):1731–1750. Kahrilas, <i>et al. Neurogastroenterol Motil</i>. 2015;<b>27</b>(2):160–74. Frazzoni, <i>et al. Neurogastroenterol Motil</i>. 2017;<b>29</b>(3)." @default.
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• W4283168114 date "2022-06-01" @default.
• W4283168114 modified "2023-09-24" @default.
• W4283168114 title "O61 Incidence of post-reflux swallow-induced peristaltic waves (PSPW) may justify referral for bravo pH reflux monitoring" @default.
• W4283168114 doi "https://doi.org/10.1136/gutjnl-2022-bsg.61" @default.
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