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• W4283169097 endingPage "1202" @default.
• W4283169097 startingPage "1183" @default.
• W4283169097 abstract "Amino acids are the essential building blocks of both synthetic and natural peptides, which are crucial for biological functions and also important as biological probes for mapping the complex protein-protein interactions (PPIs) in both prokaryotic and eukaryotic systems. Mapping the PPIs through the chemical biology approach provides pharmacologically relevant peptides, which can have agonistic or antagonistic effects on the targeted biological systems. It is evidenced that ≥ 60 peptide-based drugs have been approved by the US-FDA so far, and the number will improve further in the foreseeable future, as ≥ 140 peptides are currently in clinical trials. However, natural peptides often require fine-tuning of their pharmacological properties by strategically replacing the αL-amino acids of the peptides with non-coded amino acids (NCAA), for which codons are absent in the genetic code for biosynthesis of proteins, prior to their applications as therapeutics. Considering the diverse repertoire of the NCAAs, the conformational space of many NCAAs is yet to be explored systematically in the context of the rational design of therapeutic peptides. The current study deciphers the conformational landscape of a few such Cα-substituted aromatic NCAAs (Ing: 2-indanyl-L-Glycine; Bpa: 4-benzoyl-L-phenylalanine; Aic: 2-aminoindane-2-carboxylic acid) both in the context of tripeptides and model synthetic peptide sequences, using alanine (Ala) and proline (Pro) as the reference. The combined data obtained from the computational and biophysical studies indicate the general success of this approach, which can be exploited further to rationally design optimized peptide sequences of unusual architecture with potent antimicrobial, antiviral, gluco-regulatory, immunomodulatory, and anti-inflammatory activities." @default.
• W4283169097 created "2022-06-21" @default.
• W4283169097 creator A5012618507 @default.
• W4283169097 creator A5030388520 @default.
• W4283169097 creator A5037997534 @default.
• W4283169097 date "2022-06-20" @default.
• W4283169097 modified "2023-10-14" @default.
• W4283169097 title "Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics" @default.
• W4283169097 cites W1481645778 @default.
• W4283169097 cites W1576404915 @default.
• W4283169097 cites W175260457 @default.
• W4283169097 cites W1964580701 @default.
• W4283169097 cites W1966078827 @default.
• W4283169097 cites W1972575833 @default.
• W4283169097 cites W1986326797 @default.
• W4283169097 cites W1986331352 @default.
• W4283169097 cites W1987036950 @default.
• W4283169097 cites W1988531810 @default.
• W4283169097 cites W1990999961 @default.
• W4283169097 cites W1991523383 @default.
• W4283169097 cites W1992450378 @default.
• W4283169097 cites W1992727840 @default.
• W4283169097 cites W2001717586 @default.
• W4283169097 cites W2005169770 @default.
• W4283169097 cites W2011242238 @default.
• W4283169097 cites W2020320704 @default.
• W4283169097 cites W2025938842 @default.
• W4283169097 cites W2030514112 @default.
• W4283169097 cites W2034694458 @default.
• W4283169097 cites W2034898690 @default.
• W4283169097 cites W2039307156 @default.
• W4283169097 cites W2050000500 @default.
• W4283169097 cites W2058791329 @default.
• W4283169097 cites W2062543706 @default.
• W4283169097 cites W2064033300 @default.
• W4283169097 cites W2065974331 @default.
• W4283169097 cites W2068275014 @default.
• W4283169097 cites W2077785805 @default.
• W4283169097 cites W2082832414 @default.
• W4283169097 cites W2088848851 @default.
• W4283169097 cites W2089314426 @default.
• W4283169097 cites W2089905459 @default.
• W4283169097 cites W2096649736 @default.
• W4283169097 cites W2097337904 @default.
• W4283169097 cites W2099072501 @default.
• W4283169097 cites W2102755926 @default.
• W4283169097 cites W2104222426 @default.
• W4283169097 cites W2109967743 @default.
• W4283169097 cites W2124277348 @default.
• W4283169097 cites W2127718743 @default.
• W4283169097 cites W2128532174 @default.
• W4283169097 cites W2148613841 @default.
• W4283169097 cites W2154292631 @default.
• W4283169097 cites W2155395547 @default.
• W4283169097 cites W2158596055 @default.
• W4283169097 cites W2292382961 @default.
• W4283169097 cites W2413403526 @default.
• W4283169097 cites W2480653744 @default.
• W4283169097 cites W2514553266 @default.
• W4283169097 cites W2516149138 @default.
• W4283169097 cites W2516283850 @default.
• W4283169097 cites W2546472373 @default.
• W4283169097 cites W2633511341 @default.
• W4283169097 cites W2724823461 @default.
• W4283169097 cites W2752513086 @default.
• W4283169097 cites W2777646885 @default.
• W4283169097 cites W2806578704 @default.
• W4283169097 cites W2806782218 @default.
• W4283169097 cites W2806957894 @default.
• W4283169097 cites W2883210621 @default.
• W4283169097 cites W2937351326 @default.
• W4283169097 cites W2969773529 @default.
• W4283169097 cites W2971579247 @default.
• W4283169097 cites W2996508375 @default.
• W4283169097 cites W2996818947 @default.
• W4283169097 cites W3001942526 @default.
• W4283169097 cites W3004279507 @default.
• W4283169097 cites W3014067025 @default.
• W4283169097 cites W3040996852 @default.
• W4283169097 cites W3045715678 @default.
• W4283169097 cites W3084554823 @default.
• W4283169097 cites W3087613416 @default.
• W4283169097 cites W3092909579 @default.
• W4283169097 cites W3099724881 @default.
• W4283169097 cites W3113071045 @default.
• W4283169097 cites W3115709214 @default.
• W4283169097 cites W3146146911 @default.
• W4283169097 cites W3161240351 @default.
• W4283169097 cites W3196450189 @default.
• W4283169097 cites W4234960494 @default.
• W4283169097 cites W4243226078 @default.
• W4283169097 cites W4280502247 @default.
• W4283169097 cites W2005824132 @default.
• W4283169097 doi "https://doi.org/10.1007/s00726-022-03175-z" @default.
• W4283169097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35723743" @default.
• W4283169097 hasPublicationYear "2022" @default.
• W4283169097 type Work @default.
• W4283169097 citedByCount "3" @default.

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