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• W4283169701 abstract "Some BDNF (brain-derived neurotrophic factor)-targeted microRNAs such as miR-30a-5p associate with alcohol dependence phenomenon however their relationship with AWS is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare obtained results with clinics of AWS. Additionally, we studied relative serum content of miR-30a-5p, a microRNA which does not target BDNF but relates to alcohol use disorder. Serum BDNF concentration increased over the course of alcohol abstinence, contrary relative content of miR-122 but not miR-30a-5p decreased. Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Relative content of miR-122 negatively correlated with depression and state anxiety levels on 8th day of abstinence. According to multiple regressions on 21st day of abstinence alcohol craving and cognitive disturbances may be predictors of serum BDNF concentration, and vice versa. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity.Nekotorye mikroRNK, mishen'iu kotorykh iavliaetsia mRNK neĭrotroficheskogo faktora mozga (BDNF, brain-derived neurotrophic factor), naprimer, miR-30a-5p, mogut byt' sviazany s fenomenom zavisimosti ot alkogolia. Odnako dinamika dannogo pokazatelia v khode sindroma otmeny alkogolia (SOA) ne opisana. Tsel'iu nastoiashcheĭ raboty bylo opredelenie kontsentratsii BDNF i urovnia miR-30a-5p v syvorotke krovi lits s sindromom zavisimosti ot alkogolia v dinamike SOA, a takzhe sopostavlenie poluchennykh rezul'tatov s klinicheskoĭ kartinoĭ SOA. Krome togo, issledovali uroven' miR-122, sviaz' kotoroĭ s proiavleniiami upotrebleniia alkogolia izvestna, no BDNF ne iavliaetsia ee opisannoĭ mishen'iu. Po mere reduktsii simptomatiki SOA otmecheno dostovernoe povyshenie kontsentratsii BDNF v syvorotke krovi. Naprotiv, uroven' miR-122, no ne miR-30a-5p, snizhalsia. V dinamike SOA vyiavlena otritsatel'naia korreliatsiia mezhdu urovnem miR-122 (no ne miR-30a-5p) i kontsentratsieĭ BDNF v syvorotke krovi. Na 8 den' abstinentsii otmechena obratnaia korreliatsiia mezhdu urovnem miR-122 v syvorotke krovi i urovnem depressivnosti i lichnostnoĭ trevozhnosti. Pri provedenii mnozhestvennogo regressionnogo analiza ustanovleno, chto stepen' vyrazhennosti vlecheniia k alkogoliu i narusheniĭ kognitivnykh sposobnosteĭ mogut iavliat'sia prediktorami kontsentratsii BDNF v syvorotke krovi na 21 den' abstinentsii. BDNF, v svoiu ochered', takzhe mozhet predskazyvat' izmeneniia dannykh pokazateleĭ. Takim obrazom, kontsentratsiia BDNF i uroven' miR-122 v syvorotke krovi vzaimosviazany s nekotorymi klinicheskimi proiavleniiami SOA i mogut iavliat'sia zven'iami patogeneza, opredeliaiushchimi tiazhest' étogo sindroma." @default.
• W4283169701 created "2022-06-21" @default.
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• W4283169701 date "2022-01-01" @default.
• W4283169701 modified "2023-09-28" @default.
• W4283169701 title "Contents of BDNF, miR-30a-5p and miR-122 during alcohol withdrawal syndrome" @default.
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• W4283169701 doi "https://doi.org/10.18097/pbmc20226803218" @default.
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