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- W4283169882 abstract "The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell development. Although in vitro biochemical assays suggest that HMG proteins can serve as architectural elements in the assembly of higher-order nuclear organization, the contribution of TCF-1 on the control of three-dimensional (3D) genome structures during T cell development remains unknown. Here, we investigated the role of TCF-1 in 3D genome reconfiguration. Using gain- and loss-of-function experiments, we discovered that the co-occupancy of TCF-1 and the architectural protein CTCF altered the structure of topologically associating domains in T cell progenitors, leading to interactions between previously insulated regulatory elements and target genes at late stages of T cell development. The TCF-1-dependent gain in long-range interactions was linked to deposition of active enhancer mark H3K27ac and recruitment of the cohesin-loading factor NIPBL at active enhancers. These data indicate that TCF-1 has a role in controlling global genome organization during T cell development." @default.
- W4283169882 created "2022-06-21" @default.
- W4283169882 creator A5008927117 @default.
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- W4283169882 date "2022-06-20" @default.
- W4283169882 modified "2023-10-17" @default.
- W4283169882 title "TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors" @default.
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- W4283169882 doi "https://doi.org/10.1038/s41590-022-01232-z" @default.
- W4283169882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35726060" @default.
- W4283169882 hasPublicationYear "2022" @default.
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