FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283171108> ?p ?o ?g. }

• W4283171108 abstract "Background: Lung adenocarcinoma (LUAD) is a highly malignant cancer with a bleak prognosis. Pyroptosis is crucial in LUAD. The present study investigated the prognostic value of a pyroptosis-related signature in LUAD. Methods: LUAD's genomic data were downloaded from TCGA and GEO databases. K-means clustering was used to classify the data based on pyroptosis-related genes (PRGs). The features of tumor microenvironment were compared between the two subtypes. Differentially expressed genes (DEGs) were identified between the two subtypes, and functional enrichment and module analysis were carried out. LASSO Cox regression was used to build a prognostic model. Its prognostic value was assessed. Results: In LUAD, genetic and transcriptional changes in PRGs were found. A total of 30 PRGs were found to be differentially expressed in LUAD tissues. Based on PRGs, LUAD patients were divided into two subgroups. Subtype 1 has a higher overall survival rate than subtype 2. The tumor microenvironment characteristics of the two subtypes differed significantly. Compared to subtype 1, subtype 2 had strong immunological infiltration. Between the two groups, 719 DEGs were discovered. WGCNA used these DEGs to build a co-expression network. The network modules were analyzed. A prognostic model based on seven genes was developed, including FOSL1, KRT6A, GPR133, TMPRSS2, PRDM16, SFTPB, and SFTA3. The developed model was linked to overall survival and response to immunotherapy in patients with LUAD. Conclusion: In LUAD, a pyroptosis-related signature was developed to predict overall survival and treatment responses to immunotherapy." @default.
• W4283171108 created "2022-06-21" @default.
• W4283171108 creator A5005897893 @default.
• W4283171108 creator A5031061480 @default.
• W4283171108 creator A5038660772 @default.
• W4283171108 creator A5055914152 @default.
• W4283171108 creator A5059333386 @default.
• W4283171108 creator A5060654661 @default.
• W4283171108 creator A5075577992 @default.
• W4283171108 creator A5076980596 @default.
• W4283171108 date "2022-06-20" @default.
• W4283171108 modified "2023-09-29" @default.
• W4283171108 title "A Pyroptosis-Related Signature Predicts Overall Survival and Immunotherapy Responses in Lung Adenocarcinoma" @default.
• W4283171108 cites W1966327575 @default.
• W4283171108 cites W1985987855 @default.
• W4283171108 cites W2155430118 @default.
• W4283171108 cites W2163294546 @default.
• W4283171108 cites W2169101662 @default.
• W4283171108 cites W2398131194 @default.
• W4283171108 cites W2467417577 @default.
• W4283171108 cites W2472596403 @default.
• W4283171108 cites W2525429999 @default.
• W4283171108 cites W2586522715 @default.
• W4283171108 cites W2589021658 @default.
• W4283171108 cites W2655262992 @default.
• W4283171108 cites W2767298009 @default.
• W4283171108 cites W2775971119 @default.
• W4283171108 cites W2785803176 @default.
• W4283171108 cites W2885788218 @default.
• W4283171108 cites W2889646458 @default.
• W4283171108 cites W2898306085 @default.
• W4283171108 cites W2923986778 @default.
• W4283171108 cites W2972758365 @default.
• W4283171108 cites W2975497362 @default.
• W4283171108 cites W2979618235 @default.
• W4283171108 cites W2989083977 @default.
• W4283171108 cites W2995822774 @default.
• W4283171108 cites W3000070916 @default.
• W4283171108 cites W3006825051 @default.
• W4283171108 cites W3025783536 @default.
• W4283171108 cites W3094199365 @default.
• W4283171108 cites W3097418166 @default.
• W4283171108 cites W3110051790 @default.
• W4283171108 cites W3114743310 @default.
• W4283171108 cites W3144571741 @default.
• W4283171108 cites W3155034149 @default.
• W4283171108 cites W3157776632 @default.
• W4283171108 cites W3173310414 @default.
• W4283171108 cites W3184003637 @default.
• W4283171108 cites W3200722425 @default.
• W4283171108 cites W3205912411 @default.
• W4283171108 cites W3206809615 @default.
• W4283171108 cites W4294329053 @default.
• W4283171108 doi "https://doi.org/10.3389/fgene.2022.891301" @default.
• W4283171108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35795208" @default.
• W4283171108 hasPublicationYear "2022" @default.
• W4283171108 type Work @default.
• W4283171108 citedByCount "2" @default.
• W4283171108 countsByYear W42831711082023 @default.
• W4283171108 crossrefType "journal-article" @default.
• W4283171108 hasAuthorship W4283171108A5005897893 @default.
• W4283171108 hasAuthorship W4283171108A5031061480 @default.
• W4283171108 hasAuthorship W4283171108A5038660772 @default.
• W4283171108 hasAuthorship W4283171108A5055914152 @default.
• W4283171108 hasAuthorship W4283171108A5059333386 @default.
• W4283171108 hasAuthorship W4283171108A5060654661 @default.
• W4283171108 hasAuthorship W4283171108A5075577992 @default.
• W4283171108 hasAuthorship W4283171108A5076980596 @default.
• W4283171108 hasBestOaLocation W42831711081 @default.
• W4283171108 hasConcept C10515644 @default.
• W4283171108 hasConcept C121608353 @default.
• W4283171108 hasConcept C126322002 @default.
• W4283171108 hasConcept C143998085 @default.
• W4283171108 hasConcept C17172800 @default.
• W4283171108 hasConcept C190283241 @default.
• W4283171108 hasConcept C203014093 @default.
• W4283171108 hasConcept C2776107976 @default.
• W4283171108 hasConcept C2777701055 @default.
• W4283171108 hasConcept C2781182431 @default.
• W4283171108 hasConcept C31573885 @default.
• W4283171108 hasConcept C502942594 @default.
• W4283171108 hasConcept C50382708 @default.
• W4283171108 hasConcept C54355233 @default.
• W4283171108 hasConcept C70721500 @default.
• W4283171108 hasConcept C71924100 @default.
• W4283171108 hasConcept C86803240 @default.
• W4283171108 hasConcept C8891405 @default.
• W4283171108 hasConceptScore W4283171108C10515644 @default.
• W4283171108 hasConceptScore W4283171108C121608353 @default.
• W4283171108 hasConceptScore W4283171108C126322002 @default.
• W4283171108 hasConceptScore W4283171108C143998085 @default.
• W4283171108 hasConceptScore W4283171108C17172800 @default.
• W4283171108 hasConceptScore W4283171108C190283241 @default.
• W4283171108 hasConceptScore W4283171108C203014093 @default.
• W4283171108 hasConceptScore W4283171108C2776107976 @default.
• W4283171108 hasConceptScore W4283171108C2777701055 @default.
• W4283171108 hasConceptScore W4283171108C2781182431 @default.
• W4283171108 hasConceptScore W4283171108C31573885 @default.
• W4283171108 hasConceptScore W4283171108C502942594 @default.
• W4283171108 hasConceptScore W4283171108C50382708 @default.

• next