Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283171431> ?p ?o ?g. }
- W4283171431 endingPage "162" @default.
- W4283171431 startingPage "151" @default.
- W4283171431 abstract "Abstract Genome‐wide association studies (GWAS) have identified multiple genomic regions associated with schizophrenia, although many variants reside in noncoding regions characterized by high linkage disequilibrium (LD) making the elucidation of molecular mechanisms challenging. A genomic region on chromosome 10q24 has been consistently associated with schizophrenia with risk attributed to the AS3MT gene. Although AS3MT is hypothesized to play a role in neuronal development and differentiation, work to fully understand the function of this gene has been limited. In this study we explored the function of AS3MT using a neuronal cell line (SH‐SY5Y). We confirm previous findings of isoform specific expression of AS3MT during SH‐SY5Y differentiation toward neuronal fates. Using CRISPR‐Cas9 gene editing we generated AS3MT knockout SH‐SY5Y cell lines and used RNA‐seq to identify significant changes in gene expression in pathways associated with neuronal development, inflammation, extracellular matrix formation, and RNA processing, including dysregulation of other genes strongly implicated in schizophrenia. We did not observe any morphological changes in cell size and neurite length following neuronal differentiation and MAP2 immunocytochemistry. These results provide novel insights into the potential role of AS3MT in brain development and identify pathways through which genetic variation in this region may confer risk for schizophrenia." @default.
- W4283171431 created "2022-06-21" @default.
- W4283171431 creator A5018092286 @default.
- W4283171431 creator A5020002548 @default.
- W4283171431 creator A5045847158 @default.
- W4283171431 creator A5060580344 @default.
- W4283171431 creator A5061862935 @default.
- W4283171431 creator A5063570563 @default.
- W4283171431 creator A5064374213 @default.
- W4283171431 creator A5068873632 @default.
- W4283171431 date "2022-06-19" @default.
- W4283171431 modified "2023-10-17" @default.
- W4283171431 title "Functional characterization of the schizophrenia associated gene <scp> <i>AS3MT</i> </scp> identifies a role in neuronal development" @default.
- W4283171431 cites W1765510456 @default.
- W4283171431 cites W1820845817 @default.
- W4283171431 cites W1951878306 @default.
- W4283171431 cites W1963673462 @default.
- W4283171431 cites W1967677513 @default.
- W4283171431 cites W1977595105 @default.
- W4283171431 cites W1977709885 @default.
- W4283171431 cites W1984615306 @default.
- W4283171431 cites W1992902151 @default.
- W4283171431 cites W1996691843 @default.
- W4283171431 cites W2010850805 @default.
- W4283171431 cites W2016623538 @default.
- W4283171431 cites W2018286352 @default.
- W4283171431 cites W2023171821 @default.
- W4283171431 cites W2024791530 @default.
- W4283171431 cites W2051314902 @default.
- W4283171431 cites W2052714999 @default.
- W4283171431 cites W2060801754 @default.
- W4283171431 cites W2072007451 @default.
- W4283171431 cites W2092598954 @default.
- W4283171431 cites W2093141219 @default.
- W4283171431 cites W2101357408 @default.
- W4283171431 cites W2107060225 @default.
- W4283171431 cites W2111863354 @default.
- W4283171431 cites W2115807273 @default.
- W4283171431 cites W2119204091 @default.
- W4283171431 cites W2132853326 @default.
- W4283171431 cites W2138207763 @default.
- W4283171431 cites W2144034070 @default.
- W4283171431 cites W2153565632 @default.
- W4283171431 cites W2169456326 @default.
- W4283171431 cites W2179438025 @default.
- W4283171431 cites W2219957567 @default.
- W4283171431 cites W2281449070 @default.
- W4283171431 cites W2308672149 @default.
- W4283171431 cites W2313163856 @default.
- W4283171431 cites W2347179419 @default.
- W4283171431 cites W2414247940 @default.
- W4283171431 cites W2480249598 @default.
- W4283171431 cites W2510420694 @default.
- W4283171431 cites W2519682237 @default.
- W4283171431 cites W2564147820 @default.
- W4283171431 cites W2581824660 @default.
- W4283171431 cites W2583919602 @default.
- W4283171431 cites W2611902701 @default.
- W4283171431 cites W2755356549 @default.
- W4283171431 cites W2765389138 @default.
- W4283171431 cites W2777388159 @default.
- W4283171431 cites W2902416049 @default.
- W4283171431 cites W2907599563 @default.
- W4283171431 cites W2943149722 @default.
- W4283171431 cites W2951325776 @default.
- W4283171431 cites W2964242398 @default.
- W4283171431 cites W2975424845 @default.
- W4283171431 cites W2998741351 @default.
- W4283171431 cites W2999813022 @default.
- W4283171431 cites W3111642072 @default.
- W4283171431 cites W3157396776 @default.
- W4283171431 cites W4223520055 @default.
- W4283171431 cites W4283171431 @default.
- W4283171431 doi "https://doi.org/10.1002/ajmg.b.32905" @default.
- W4283171431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35719055" @default.
- W4283171431 hasPublicationYear "2022" @default.
- W4283171431 type Work @default.
- W4283171431 citedByCount "2" @default.
- W4283171431 countsByYear W42831714312022 @default.
- W4283171431 countsByYear W42831714312023 @default.
- W4283171431 crossrefType "journal-article" @default.
- W4283171431 hasAuthorship W4283171431A5018092286 @default.
- W4283171431 hasAuthorship W4283171431A5020002548 @default.
- W4283171431 hasAuthorship W4283171431A5045847158 @default.
- W4283171431 hasAuthorship W4283171431A5060580344 @default.
- W4283171431 hasAuthorship W4283171431A5061862935 @default.
- W4283171431 hasAuthorship W4283171431A5063570563 @default.
- W4283171431 hasAuthorship W4283171431A5064374213 @default.
- W4283171431 hasAuthorship W4283171431A5068873632 @default.
- W4283171431 hasBestOaLocation W42831714312 @default.
- W4283171431 hasConcept C104317684 @default.
- W4283171431 hasConcept C106208931 @default.
- W4283171431 hasConcept C135763542 @default.
- W4283171431 hasConcept C150194340 @default.
- W4283171431 hasConcept C153209595 @default.
- W4283171431 hasConcept C169760540 @default.
- W4283171431 hasConcept C2796436 @default.
- W4283171431 hasConcept C54355233 @default.