FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283172328> ?p ?o ?g. }

• W4283172328 abstract "<p> </p> <p><strong>Objective</strong> To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment.</p> <p><strong>Research Design and Methods </strong> We measured fasting glucose, free fatty acids (FFA), glycerol, β-hydroxybutyrate, acetoacetate, lactate, and pyruvate concentrations in 3,581 samples from the CANVAS trial at baseline and at 1 and 2 years after randomization. Results were analyzed by univariate and multivariate Cox proportional hazards models. </p> <p><strong>Results</strong> Patients in the lowest baseline FFA tertile were more often men with a longer duration of T2D, higher urinary albumin excretion and lower HDL-cholesterol levels, higher history of CVD, and higher use of statins and insulin. Using all 7 metabolites as predictors, FFA were inversely associated with incident hospitalized HHF (0.33 [0.21–0.55]), while glycerol was a positive predictor (2.21 [1.45–3.35]). In a model further adjusted for 16 potential confounders (including prior HF and CV disease and pharmacologic therapies), FFA remained a significant negative predictor. FFA and glycerol also predicted CV mortality (0.53 [0.35–0.81] and 1.81 [1.26–2.58], respectively) and all-cause death (0.50 [0.36–0.70] and 1.64 [1.22–2.18]). When added to these models, background insulin therapy was an independent positive predictor of risk of death. Canagliflozin treatment significantly increased plasma FFA and β-hydroxybutyrate regardless of background antihyperglycemic therapy. </p> <p><strong>Conclusions</strong> A constitutive metabolic setup consisting of higher lipolysis may be beneficial in delaying or preventing HHF; a further stimulation of lipolysis by canagliflozin may reinforce this influence. </p>" @default.
• W4283172328 created "2022-06-21" @default.
• W4283172328 creator A5004194306 @default.
• W4283172328 creator A5006832486 @default.
• W4283172328 creator A5010661645 @default.
• W4283172328 creator A5027520502 @default.
• W4283172328 creator A5031260299 @default.
• W4283172328 creator A5032498279 @default.
• W4283172328 creator A5039432822 @default.
• W4283172328 creator A5053710319 @default.
• W4283172328 creator A5066887782 @default.
• W4283172328 creator A5075162144 @default.
• W4283172328 creator A5089847244 @default.
• W4283172328 creator A5090693719 @default.
• W4283172328 date "2022-06-20" @default.
• W4283172328 modified "2023-09-27" @default.
• W4283172328 title "Fasting substrate concentrations predict cardiovascular outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)" @default.
• W4283172328 doi "https://doi.org/10.2337/figshare.19747645.v1" @default.
• W4283172328 hasPublicationYear "2022" @default.
• W4283172328 type Work @default.
• W4283172328 citedByCount "0" @default.
• W4283172328 crossrefType "posted-content" @default.
• W4283172328 hasAuthorship W4283172328A5004194306 @default.
• W4283172328 hasAuthorship W4283172328A5006832486 @default.
• W4283172328 hasAuthorship W4283172328A5010661645 @default.
• W4283172328 hasAuthorship W4283172328A5027520502 @default.
• W4283172328 hasAuthorship W4283172328A5031260299 @default.
• W4283172328 hasAuthorship W4283172328A5032498279 @default.
• W4283172328 hasAuthorship W4283172328A5039432822 @default.
• W4283172328 hasAuthorship W4283172328A5053710319 @default.
• W4283172328 hasAuthorship W4283172328A5066887782 @default.
• W4283172328 hasAuthorship W4283172328A5075162144 @default.
• W4283172328 hasAuthorship W4283172328A5089847244 @default.
• W4283172328 hasAuthorship W4283172328A5090693719 @default.
• W4283172328 hasBestOaLocation W42831723281 @default.
• W4283172328 hasConcept C126322002 @default.
• W4283172328 hasConcept C134018914 @default.
• W4283172328 hasConcept C2777180221 @default.
• W4283172328 hasConcept C2777451236 @default.
• W4283172328 hasConcept C555293320 @default.
• W4283172328 hasConcept C71924100 @default.
• W4283172328 hasConcept C77350462 @default.
• W4283172328 hasConceptScore W4283172328C126322002 @default.
• W4283172328 hasConceptScore W4283172328C134018914 @default.
• W4283172328 hasConceptScore W4283172328C2777180221 @default.
• W4283172328 hasConceptScore W4283172328C2777451236 @default.
• W4283172328 hasConceptScore W4283172328C555293320 @default.
• W4283172328 hasConceptScore W4283172328C71924100 @default.
• W4283172328 hasConceptScore W4283172328C77350462 @default.
• W4283172328 hasLocation W42831723281 @default.
• W4283172328 hasOpenAccess W4283172328 @default.
• W4283172328 hasPrimaryLocation W42831723281 @default.
• W4283172328 hasRelatedWork W1966504330 @default.
• W4283172328 hasRelatedWork W1974041167 @default.
• W4283172328 hasRelatedWork W1979139803 @default.
• W4283172328 hasRelatedWork W2030889776 @default.
• W4283172328 hasRelatedWork W2037631372 @default.
• W4283172328 hasRelatedWork W2040058909 @default.
• W4283172328 hasRelatedWork W2127396703 @default.
• W4283172328 hasRelatedWork W2132898409 @default.
• W4283172328 hasRelatedWork W2748952813 @default.
• W4283172328 hasRelatedWork W4249176446 @default.
• W4283172328 isParatext "false" @default.
• W4283172328 isRetracted "false" @default.
• W4283172328 workType "article" @default.