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- W42831803 abstract "This chapter discusses the control of growth and differentiation in normal and malignant leukocytes. The genetic change that allows the leukemic cells to grow in the absence of macrophage and granulocyte inducer (MGI) can then be followed by other genetic changes that can produce different blocks in differentiation. The isolation and study of such cell mutants has also made it possible to develop an experimental system that has been used to genetically dissect the controls that regulate induction of a variety of internal and external differentiation-associated markers that are switched on by the normal regulatory protein during differentiation to mature macrophages and granulocytes. Experiments with leukemic cell clones with different degrees of competence for the induction of normal differentiation by MGI have shown that differences in competence are associated with specific membrane changes, including the mobility of certain surface receptors, the ability for hormone desensitization, and the production of type C RNA viruses." @default.
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- W42831803 date "1979-01-01" @default.
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- W42831803 title "CONTROL OF GROWTH AND DIFFERENTIATION IN NORMAL AND MALIGNANT LEUKOCYTES: THE PROTEIN REGULATORS MGI AND TCI" @default.
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- W42831803 doi "https://doi.org/10.1016/b978-0-12-569650-0.50072-3" @default.
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