Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283204381> ?p ?o ?g. }
- W4283204381 endingPage "511" @default.
- W4283204381 startingPage "503" @default.
- W4283204381 abstract "The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD.International (20 center), retrospective cohort from the Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) with radiologic or histopathologic FCD after surgery. Images processed using the MELD protocol, masked with 3D regions-of-interest (ROI), and co-registered to fsaverage_sym (symmetric template). FCDs were then co-localized to 1 of 7 distributed functional cortical networks. Negative binomial regression evaluated effect of FCD size, network, histology, and sulcal depth on age of epilepsy onset. From this model, predictive age of epilepsy onset was calculated for each network.Three hundred eighty-eight patients had median age seizure onset 5 years (interquartile range [IQR] = 3-11 years), median age at pre-operative scan 18 years (IQR = 11-28 years). FCDs co-localized to the following networks: limbic (90), default mode (87), somatomotor (65), front parietal control (52), ventral attention (32), dorsal attention (31), and visual (31). Larger lesions were associated with younger age of onset (p = 0.01); age of epilepsy onset was associated with dominant network (p = 0.04) but not sulcal depth or histology. Sensorimotor networks had youngest onset; the limbic network had oldest age of onset (p values <0.05).FCD co-localization to distributed functional cortical networks is associated with age of epilepsy onset: sensory neural networks (somatomotor and visual) with earlier onset, and limbic latest onset. These variations may reflect developmental differences in synaptic/white matter maturation or network activation and may provide a biological basis for age-dependent epilepsy onset expression. ANN NEUROL 2022;92:503-511." @default.
- W4283204381 created "2022-06-22" @default.
- W4283204381 creator A5001718708 @default.
- W4283204381 creator A5023710076 @default.
- W4283204381 creator A5027234117 @default.
- W4283204381 creator A5032016347 @default.
- W4283204381 creator A5034081125 @default.
- W4283204381 creator A5036510142 @default.
- W4283204381 creator A5046016423 @default.
- W4283204381 creator A5052018760 @default.
- W4283204381 creator A5059328735 @default.
- W4283204381 creator A5063154019 @default.
- W4283204381 creator A5064225406 @default.
- W4283204381 creator A5090079450 @default.
- W4283204381 date "2022-07-08" @default.
- W4283204381 modified "2023-10-17" @default.
- W4283204381 title "Networks Underlie Temporal Onset of Dysplasia‐Related Epilepsy: A <scp>MELD</scp> Study" @default.
- W4283204381 cites W1924326075 @default.
- W4283204381 cites W1967083130 @default.
- W4283204381 cites W1972225310 @default.
- W4283204381 cites W1987865892 @default.
- W4283204381 cites W1988811283 @default.
- W4283204381 cites W1996954170 @default.
- W4283204381 cites W2007829231 @default.
- W4283204381 cites W2008069127 @default.
- W4283204381 cites W2010917685 @default.
- W4283204381 cites W2037689983 @default.
- W4283204381 cites W2066073124 @default.
- W4283204381 cites W2067456724 @default.
- W4283204381 cites W2069239049 @default.
- W4283204381 cites W2087327647 @default.
- W4283204381 cites W2101400241 @default.
- W4283204381 cites W2103642624 @default.
- W4283204381 cites W2107836788 @default.
- W4283204381 cites W2120731293 @default.
- W4283204381 cites W2138304538 @default.
- W4283204381 cites W2140203142 @default.
- W4283204381 cites W2146396538 @default.
- W4283204381 cites W2152292563 @default.
- W4283204381 cites W2272583646 @default.
- W4283204381 cites W2585998010 @default.
- W4283204381 cites W2593448428 @default.
- W4283204381 cites W2728685917 @default.
- W4283204381 cites W2788755901 @default.
- W4283204381 cites W2795386622 @default.
- W4283204381 cites W2802556262 @default.
- W4283204381 cites W2891541616 @default.
- W4283204381 cites W2904657392 @default.
- W4283204381 cites W2913681488 @default.
- W4283204381 cites W2952589394 @default.
- W4283204381 cites W2969667716 @default.
- W4283204381 cites W3015507869 @default.
- W4283204381 cites W3122009574 @default.
- W4283204381 cites W3129430073 @default.
- W4283204381 cites W3133940865 @default.
- W4283204381 cites W3163803374 @default.
- W4283204381 cites W3176871064 @default.
- W4283204381 cites W3179308066 @default.
- W4283204381 cites W3180887856 @default.
- W4283204381 cites W3204920881 @default.
- W4283204381 cites W3216338015 @default.
- W4283204381 cites W4241074797 @default.
- W4283204381 cites W4295750005 @default.
- W4283204381 doi "https://doi.org/10.1002/ana.26442" @default.
- W4283204381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35726354" @default.
- W4283204381 hasPublicationYear "2022" @default.
- W4283204381 type Work @default.
- W4283204381 citedByCount "4" @default.
- W4283204381 countsByYear W42832043812023 @default.
- W4283204381 crossrefType "journal-article" @default.
- W4283204381 hasAuthorship W4283204381A5001718708 @default.
- W4283204381 hasAuthorship W4283204381A5023710076 @default.
- W4283204381 hasAuthorship W4283204381A5027234117 @default.
- W4283204381 hasAuthorship W4283204381A5032016347 @default.
- W4283204381 hasAuthorship W4283204381A5034081125 @default.
- W4283204381 hasAuthorship W4283204381A5036510142 @default.
- W4283204381 hasAuthorship W4283204381A5046016423 @default.
- W4283204381 hasAuthorship W4283204381A5052018760 @default.
- W4283204381 hasAuthorship W4283204381A5059328735 @default.
- W4283204381 hasAuthorship W4283204381A5063154019 @default.
- W4283204381 hasAuthorship W4283204381A5064225406 @default.
- W4283204381 hasAuthorship W4283204381A5090079450 @default.
- W4283204381 hasBestOaLocation W42832043812 @default.
- W4283204381 hasConcept C119060515 @default.
- W4283204381 hasConcept C126838900 @default.
- W4283204381 hasConcept C141071460 @default.
- W4283204381 hasConcept C141516989 @default.
- W4283204381 hasConcept C142724271 @default.
- W4283204381 hasConcept C143409427 @default.
- W4283204381 hasConcept C15744967 @default.
- W4283204381 hasConcept C169760540 @default.
- W4283204381 hasConcept C2777060296 @default.
- W4283204381 hasConcept C2777767895 @default.
- W4283204381 hasConcept C2778186239 @default.
- W4283204381 hasConcept C2779134260 @default.
- W4283204381 hasConcept C2779226451 @default.
- W4283204381 hasConcept C71924100 @default.
- W4283204381 hasConcept C72563966 @default.