FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283206412> ?p ?o ?g. }

• W4283206412 endingPage "1209" @default.
• W4283206412 startingPage "1209" @default.
• W4283206412 abstract "The most common joint disease in the elderly is knee osteoarthritis (OA). It is distinguished by cartilage degradation, subchondral bone loss, and a decrease in joint space. We studied the effects of carnosine (CA) on knee OA in male Wistar rats. OA is induced by anterior cruciate ligament transection combined with medial meniscectomy (ACLT+MMx) method and in vitro studies are conducted in fibroblast-like synoviocyte cells (FLS). The pain was assessed using weight-bearing and paw-withdrawal tests. CA supplementation significantly reduced pain. The enzyme-linked immunosorbent assay (ELISA) method was used to detect inflammatory proteins in the blood and intra-articular synovial fluid (IASF), and CA reduced the levels of inflammatory proteins. Histopathological studies were performed on knee-tissue samples using toluidine blue and hematoxylin and eosin (H and E) assays. CA treatment improved synovial protection and decreased cartilage degradation while decreasing zonal depth lesions. Furthermore, Western blotting studies revealed that the CA-treated group activated nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase (HO-1) and reduced the expression of cyclooxygenase-2 (COX-2). FLS cells were isolated from the knee joints and treated with IL-1β to stimulate the inflammatory response and increase reactive oxygen species (ROS). The matrix metalloproteinase protein (MMP’s) levels (MMP-3, and MMP-13) were determined using the reverse transcription-polymerase chain reaction (RT-PCR), and CA treatment reduced the MMP’s expression levels. When tested using the 2′,7′-dicholorodihydrofluroscene diacetate (DCFDA) assay and the 5,5′,6,6′-tetracholoro-1,1′,3,3′-tertraethylbenzimidazolcarboc janine iodide (JC-1) assay in augmented ROS FLS cells, CA reduced the ROS levels and improved the mitochondrial membrane permeability. This study’s investigation suggests that CA significantly alleviates knee OA both in vitro and in vivo." @default.
• W4283206412 created "2022-06-22" @default.
• W4283206412 creator A5011020900 @default.
• W4283206412 creator A5017718253 @default.
• W4283206412 creator A5022141448 @default.
• W4283206412 creator A5046085567 @default.
• W4283206412 creator A5078020678 @default.
• W4283206412 date "2022-06-20" @default.
• W4283206412 modified "2023-10-16" @default.
• W4283206412 title "Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study" @default.
• W4283206412 cites W1638095649 @default.
• W4283206412 cites W1714314790 @default.
• W4283206412 cites W1864987491 @default.
• W4283206412 cites W1893232092 @default.
• W4283206412 cites W1959450537 @default.
• W4283206412 cites W1964290021 @default.
• W4283206412 cites W1971505474 @default.
• W4283206412 cites W1973685931 @default.
• W4283206412 cites W1977510100 @default.
• W4283206412 cites W1992141923 @default.
• W4283206412 cites W1994293504 @default.
• W4283206412 cites W1995392360 @default.
• W4283206412 cites W2000468514 @default.
• W4283206412 cites W2001762931 @default.
• W4283206412 cites W2010802338 @default.
• W4283206412 cites W2017066281 @default.
• W4283206412 cites W2017741060 @default.
• W4283206412 cites W2031942183 @default.
• W4283206412 cites W2042412998 @default.
• W4283206412 cites W2044216794 @default.
• W4283206412 cites W2044445066 @default.
• W4283206412 cites W2049162094 @default.
• W4283206412 cites W2062676485 @default.
• W4283206412 cites W2074650792 @default.
• W4283206412 cites W2077766596 @default.
• W4283206412 cites W2078073940 @default.
• W4283206412 cites W2079397428 @default.
• W4283206412 cites W2082083141 @default.
• W4283206412 cites W2083151132 @default.
• W4283206412 cites W2084723930 @default.
• W4283206412 cites W2085939150 @default.
• W4283206412 cites W2099427592 @default.
• W4283206412 cites W2113670619 @default.
• W4283206412 cites W2113727407 @default.
• W4283206412 cites W2113826982 @default.
• W4283206412 cites W2162699811 @default.
• W4283206412 cites W2164982699 @default.
• W4283206412 cites W2164998622 @default.
• W4283206412 cites W2227341519 @default.
• W4283206412 cites W2261684505 @default.
• W4283206412 cites W2262385457 @default.
• W4283206412 cites W2264463083 @default.
• W4283206412 cites W2295844066 @default.
• W4283206412 cites W2302770607 @default.
• W4283206412 cites W2400190003 @default.
• W4283206412 cites W2473225763 @default.
• W4283206412 cites W2514190706 @default.
• W4283206412 cites W2518868905 @default.
• W4283206412 cites W2531097686 @default.
• W4283206412 cites W2576602781 @default.
• W4283206412 cites W2623135216 @default.
• W4283206412 cites W2655872607 @default.
• W4283206412 cites W2726121826 @default.
• W4283206412 cites W2731001527 @default.
• W4283206412 cites W2735151494 @default.
• W4283206412 cites W2748389364 @default.
• W4283206412 cites W2758074338 @default.
• W4283206412 cites W2759993885 @default.
• W4283206412 cites W2777589129 @default.
• W4283206412 cites W2782893368 @default.
• W4283206412 cites W2783671114 @default.
• W4283206412 cites W2792345070 @default.
• W4283206412 cites W2800718522 @default.
• W4283206412 cites W2801008646 @default.
• W4283206412 cites W2803590439 @default.
• W4283206412 cites W2804780541 @default.
• W4283206412 cites W2898137718 @default.
• W4283206412 cites W2902172616 @default.
• W4283206412 cites W2905782592 @default.
• W4283206412 cites W2911223795 @default.
• W4283206412 cites W2921246884 @default.
• W4283206412 cites W2922513794 @default.
• W4283206412 cites W2923669594 @default.
• W4283206412 cites W2934456842 @default.
• W4283206412 cites W2945806523 @default.
• W4283206412 cites W2947822436 @default.
• W4283206412 cites W2956575677 @default.
• W4283206412 cites W2964684793 @default.
• W4283206412 cites W2972832815 @default.
• W4283206412 cites W2987947036 @default.
• W4283206412 cites W2995540455 @default.
• W4283206412 cites W2999003924 @default.
• W4283206412 cites W3001293230 @default.
• W4283206412 cites W3005581389 @default.
• W4283206412 cites W3006981518 @default.
• W4283206412 cites W3008065079 @default.
• W4283206412 cites W3009788412 @default.
• W4283206412 cites W3009853031 @default.

• next