Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283206593> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4283206593 endingPage "275" @default.
- W4283206593 startingPage "270" @default.
- W4283206593 abstract "Abstract Introduction/Aims Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative disorder of motor neurons in which the cause is mostly unknown. Early identification of genetic ALS cases, of which C9ORF72 (C9ALS) is the most frequent, can have important implications for evaluation, prognosis, and therapeutics. Here, we aimed to characterize the clinical and electrophysiological hallmarks of C9ALS and investigate differences from C9ORF72 negative ALS (non‐C9ALS). Methods We retrospectively reviewed clinical and electrodiagnostic (EDX) data for all genetically confirmed C9ALS cases seen between 1/1/2012 and 10/1/2020 who met Gold Coast criteria and compared them 1:1 with non‐C9ALS patients within the same time frame. Results A total of 99 C9ALS and 99 non‐C9ALS cases were identified. Compared to non‐C9ALS, C9ALS demonstrated higher prevalence in women, lesser racial variability, stronger family history of ALS, and higher frequency of upper motor neuron signs. EDX testing of C9ALS showed higher median sensory nerve and lower fibular compound muscle action potential amplitudes. Discussion Although the differences between C9ALS and non‐C9ALS reached statistical significance in certain nerve conduction parameters, they were not sufficient to discriminate between groups on a case‐by‐case basis. Genetic testing is required to identify C9ALS patients." @default.
- W4283206593 created "2022-06-22" @default.
- W4283206593 creator A5021382416 @default.
- W4283206593 creator A5029561594 @default.
- W4283206593 creator A5045915035 @default.
- W4283206593 creator A5050909336 @default.
- W4283206593 creator A5052581382 @default.
- W4283206593 creator A5059748113 @default.
- W4283206593 creator A5061993863 @default.
- W4283206593 creator A5072541455 @default.
- W4283206593 date "2022-07-11" @default.
- W4283206593 modified "2023-09-27" @default.
- W4283206593 title "Clinical and electrophysiological findings in <scp><i>C9ORF72</i> ALS</scp>" @default.
- W4283206593 cites W1982638189 @default.
- W4283206593 cites W1992723082 @default.
- W4283206593 cites W1995222212 @default.
- W4283206593 cites W2023991247 @default.
- W4283206593 cites W2050626075 @default.
- W4283206593 cites W2070489632 @default.
- W4283206593 cites W2080802641 @default.
- W4283206593 cites W2092451107 @default.
- W4283206593 cites W2100765938 @default.
- W4283206593 cites W2119538681 @default.
- W4283206593 cites W2129658133 @default.
- W4283206593 cites W2138207816 @default.
- W4283206593 cites W2150523249 @default.
- W4283206593 cites W2154945114 @default.
- W4283206593 cites W2487331275 @default.
- W4283206593 cites W2584645003 @default.
- W4283206593 cites W2800497856 @default.
- W4283206593 cites W2946318278 @default.
- W4283206593 cites W2978142564 @default.
- W4283206593 cites W3005485264 @default.
- W4283206593 cites W3015315508 @default.
- W4283206593 cites W3015372504 @default.
- W4283206593 cites W3114107609 @default.
- W4283206593 cites W3118012871 @default.
- W4283206593 doi "https://doi.org/10.1002/mus.27665" @default.
- W4283206593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35727129" @default.
- W4283206593 hasPublicationYear "2022" @default.
- W4283206593 type Work @default.
- W4283206593 citedByCount "2" @default.
- W4283206593 countsByYear W42832065932022 @default.
- W4283206593 countsByYear W42832065932023 @default.
- W4283206593 crossrefType "journal-article" @default.
- W4283206593 hasAuthorship W4283206593A5021382416 @default.
- W4283206593 hasAuthorship W4283206593A5029561594 @default.
- W4283206593 hasAuthorship W4283206593A5045915035 @default.
- W4283206593 hasAuthorship W4283206593A5050909336 @default.
- W4283206593 hasAuthorship W4283206593A5052581382 @default.
- W4283206593 hasAuthorship W4283206593A5059748113 @default.
- W4283206593 hasAuthorship W4283206593A5061993863 @default.
- W4283206593 hasAuthorship W4283206593A5072541455 @default.
- W4283206593 hasConcept C126322002 @default.
- W4283206593 hasConcept C164705383 @default.
- W4283206593 hasConcept C185263204 @default.
- W4283206593 hasConcept C2777898937 @default.
- W4283206593 hasConcept C2778641062 @default.
- W4283206593 hasConcept C2779134260 @default.
- W4283206593 hasConcept C2779483572 @default.
- W4283206593 hasConcept C2780596555 @default.
- W4283206593 hasConcept C2780673598 @default.
- W4283206593 hasConcept C71924100 @default.
- W4283206593 hasConceptScore W4283206593C126322002 @default.
- W4283206593 hasConceptScore W4283206593C164705383 @default.
- W4283206593 hasConceptScore W4283206593C185263204 @default.
- W4283206593 hasConceptScore W4283206593C2777898937 @default.
- W4283206593 hasConceptScore W4283206593C2778641062 @default.
- W4283206593 hasConceptScore W4283206593C2779134260 @default.
- W4283206593 hasConceptScore W4283206593C2779483572 @default.
- W4283206593 hasConceptScore W4283206593C2780596555 @default.
- W4283206593 hasConceptScore W4283206593C2780673598 @default.
- W4283206593 hasConceptScore W4283206593C71924100 @default.
- W4283206593 hasIssue "3" @default.
- W4283206593 hasLocation W42832065931 @default.
- W4283206593 hasLocation W42832065932 @default.
- W4283206593 hasOpenAccess W4283206593 @default.
- W4283206593 hasPrimaryLocation W42832065931 @default.
- W4283206593 hasRelatedWork W2330411138 @default.
- W4283206593 hasRelatedWork W2434193208 @default.
- W4283206593 hasRelatedWork W2515492896 @default.
- W4283206593 hasRelatedWork W2623035941 @default.
- W4283206593 hasRelatedWork W2883160990 @default.
- W4283206593 hasRelatedWork W2923610821 @default.
- W4283206593 hasRelatedWork W3193048169 @default.
- W4283206593 hasRelatedWork W4239639350 @default.
- W4283206593 hasRelatedWork W4376108660 @default.
- W4283206593 hasRelatedWork W4385163564 @default.
- W4283206593 hasVolume "66" @default.
- W4283206593 isParatext "false" @default.
- W4283206593 isRetracted "false" @default.
- W4283206593 workType "article" @default.