FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283210366> ?p ?o ?g. }

• W4283210366 abstract "Abstract Background The C-X-C chemokine receptor 4 (CXCR4) has been suggested to play an important role in several types of cancers and is related to biological behaviors connected with tumor progression. However, the clinical significance and application of CXCR4 in lung cancer remain disputable. Thus, we conducted a meta-analysis to investigate the impact of CXCR4 expression on survival and clinicopathological features in lung cancer. Methods Comprehensive literature searches were conducted in PubMed, Embase and Web of Science for relevant studies. We pooled hazard ratios (HRs)/odds ratios (ORs) with 95% confidence intervals (CIs) by STATA 12.0 to evaluate the potential value of CXCR4 expression. Results Twenty-seven relevant articles involving 2932 patients with lung cancer were included in our meta-analysis. The results revealed that CXCR4 expression was apparently associated with poor overall survival (OS) (HR 1.61, 95% CI 1.42–1.82) and disease-free survival (HR 3.39, 95% CI 2.38–4.83). Furthermore, a significant correlation with poor OS was obvious in non-small cell lung cancer patients (HR 1.59, 95% CI 1.40–1.81) and in patients showing CXCR4 expression in the cytoplasm (HR 2.10, 95% CI 1.55–2.84) and the membrane (HR 1.74, 95% CI 1.24–2.45). CXCR4 expression was significantly associated with men (OR 1.32, 95% CI 1.08–1.61), advanced tumor stages (T3-T4) (OR 2.34, 95% CI 1.28–4.28), advanced nodal stages (N > 0) (OR 2.34, 95% CI 1.90–2.90), distant metastasis (OR 3.65, 95% CI 1.53–8.69), advanced TNM stages (TNM stages III, IV) (OR 3.10, 95% CI 1.95–4.93) and epidermal growth factor receptor (EGFR) expression (OR 2.44, 95% CI 1.44–4.12) but was not associated with age, smoking history, histopathology, differentiation, lymphatic vessel invasion or local recurrence. Conclusion High expression of CXCR4 is related to tumor progression and might be an adverse prognostic factor for lung cancer." @default.
• W4283210366 created "2022-06-22" @default.
• W4283210366 creator A5013912793 @default.
• W4283210366 creator A5035007741 @default.
• W4283210366 creator A5051330675 @default.
• W4283210366 creator A5076925348 @default.
• W4283210366 date "2022-06-21" @default.
• W4283210366 modified "2023-10-14" @default.
• W4283210366 title "The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis" @default.
• W4283210366 cites W1180291324 @default.
• W4283210366 cites W1438161774 @default.
• W4283210366 cites W1500037179 @default.
• W4283210366 cites W1577790581 @default.
• W4283210366 cites W1600432148 @default.
• W4283210366 cites W1973573765 @default.
• W4283210366 cites W1993124085 @default.
• W4283210366 cites W2000895546 @default.
• W4283210366 cites W2002713157 @default.
• W4283210366 cites W2016090566 @default.
• W4283210366 cites W2021053102 @default.
• W4283210366 cites W2022044609 @default.
• W4283210366 cites W2034236055 @default.
• W4283210366 cites W2041910525 @default.
• W4283210366 cites W2056998032 @default.
• W4283210366 cites W2057313199 @default.
• W4283210366 cites W2057516761 @default.
• W4283210366 cites W2059024833 @default.
• W4283210366 cites W2062740203 @default.
• W4283210366 cites W2070990188 @default.
• W4283210366 cites W2080293266 @default.
• W4283210366 cites W2088092597 @default.
• W4283210366 cites W2095314787 @default.
• W4283210366 cites W2110620425 @default.
• W4283210366 cites W2116475791 @default.
• W4283210366 cites W2119011446 @default.
• W4283210366 cites W2126878117 @default.
• W4283210366 cites W2134066744 @default.
• W4283210366 cites W2140382736 @default.
• W4283210366 cites W2146103683 @default.
• W4283210366 cites W2156285412 @default.
• W4283210366 cites W2156323704 @default.
• W4283210366 cites W2159913536 @default.
• W4283210366 cites W2164381118 @default.
• W4283210366 cites W2170447440 @default.
• W4283210366 cites W2190581094 @default.
• W4283210366 cites W2198066495 @default.
• W4283210366 cites W2253193571 @default.
• W4283210366 cites W2405363290 @default.
• W4283210366 cites W2413645866 @default.
• W4283210366 cites W2557310739 @default.
• W4283210366 cites W2562597003 @default.
• W4283210366 cites W2626468041 @default.
• W4283210366 cites W2753983868 @default.
• W4283210366 cites W2757235467 @default.
• W4283210366 cites W2761677580 @default.
• W4283210366 cites W2762144498 @default.
• W4283210366 cites W2771032906 @default.
• W4283210366 cites W2803358834 @default.
• W4283210366 cites W2810941072 @default.
• W4283210366 cites W2884828562 @default.
• W4283210366 cites W2886184951 @default.
• W4283210366 cites W2887309074 @default.
• W4283210366 cites W2898605926 @default.
• W4283210366 cites W2901159443 @default.
• W4283210366 cites W2901412696 @default.
• W4283210366 cites W2902238727 @default.
• W4283210366 cites W2982052245 @default.
• W4283210366 cites W2982372328 @default.
• W4283210366 cites W2994851025 @default.
• W4283210366 cites W2996077038 @default.
• W4283210366 cites W2997951015 @default.
• W4283210366 cites W3003349110 @default.
• W4283210366 cites W3010327973 @default.
• W4283210366 cites W3012232408 @default.
• W4283210366 cites W3015446222 @default.
• W4283210366 cites W3183827287 @default.
• W4283210366 cites W4292165628 @default.
• W4283210366 doi "https://doi.org/10.1186/s12885-022-09756-1" @default.
• W4283210366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35729596" @default.
• W4283210366 hasPublicationYear "2022" @default.
• W4283210366 type Work @default.
• W4283210366 citedByCount "7" @default.
• W4283210366 countsByYear W42832103662022 @default.
• W4283210366 countsByYear W42832103662023 @default.
• W4283210366 crossrefType "journal-article" @default.
• W4283210366 hasAuthorship W4283210366A5013912793 @default.
• W4283210366 hasAuthorship W4283210366A5035007741 @default.
• W4283210366 hasAuthorship W4283210366A5051330675 @default.
• W4283210366 hasAuthorship W4283210366A5076925348 @default.
• W4283210366 hasBestOaLocation W42832103661 @default.
• W4283210366 hasConcept C121608353 @default.
• W4283210366 hasConcept C126322002 @default.
• W4283210366 hasConcept C129470790 @default.
• W4283210366 hasConcept C13373296 @default.
• W4283210366 hasConcept C143998085 @default.
• W4283210366 hasConcept C156957248 @default.
• W4283210366 hasConcept C170493617 @default.
• W4283210366 hasConcept C207103383 @default.
• W4283210366 hasConcept C2776256026 @default.
• W4283210366 hasConcept C2780140570 @default.

• next