Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283214294> ?p ?o ?g. }
- W4283214294 abstract "The high mortality rate of patients with diabetic foot ulcers is urging the appearance of an effective biomedical drug. Senescence is one of the major reasons of aging-induced decline in the diabetic wound. Our previous studies have demonstrated the anti-senescence effect of secretomes derived from human fetal mesenchymal stem cells (hfMSC). The present study tends to explore the potential role of hfMSC secretome (HFS) in wound healing through anti-aging. Meanwhile, we try to overcome several obstacles in the clinical application of stem cell secretome. A verticle bioreactor and microcarriers are employed to expand hfMSC and produce the HFS on a large scale. The HFS was then subjected to lyophilization (L-HFS). The PLGA (poly lactic-co-glycolic acid) particles were used to encapsulate and protect L-HFS from degradation in the streptozotocin (STZ)-induced diabetic rat model. Results showed that HFS-PLGA significantly enhanced wound healing by promoting vascularization and inhibiting inflammation in the skin wound bed. We further analyzed the contents of HFS. Isobaric tag for relative and absolute quantitation (ITRAQ) and label-free methods were used to identify peptides in the secretome. Bioinformatics analysis indicated that exosome production-related singling pathways and heat-shock protein family could be used as bio-functional markers and quality control for stem cell secretome production." @default.
- W4283214294 created "2022-06-22" @default.
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- W4283214294 date "2022-06-21" @default.
- W4283214294 modified "2023-10-17" @default.
- W4283214294 title "Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family" @default.
- W4283214294 cites W1550904008 @default.
- W4283214294 cites W1567481505 @default.
- W4283214294 cites W1893483893 @default.
- W4283214294 cites W1968323108 @default.
- W4283214294 cites W1971634317 @default.
- W4283214294 cites W1978245655 @default.
- W4283214294 cites W1980645442 @default.
- W4283214294 cites W1984606861 @default.
- W4283214294 cites W1986351521 @default.
- W4283214294 cites W1987246200 @default.
- W4283214294 cites W2000201844 @default.
- W4283214294 cites W2000389316 @default.
- W4283214294 cites W2004303921 @default.
- W4283214294 cites W2005943573 @default.
- W4283214294 cites W2006211285 @default.
- W4283214294 cites W2014904868 @default.
- W4283214294 cites W2016039768 @default.
- W4283214294 cites W2021527262 @default.
- W4283214294 cites W2024409084 @default.
- W4283214294 cites W2025466497 @default.
- W4283214294 cites W2026985226 @default.
- W4283214294 cites W2034921827 @default.
- W4283214294 cites W2036887368 @default.
- W4283214294 cites W2044155847 @default.
- W4283214294 cites W2047254124 @default.
- W4283214294 cites W2049655446 @default.
- W4283214294 cites W2058647415 @default.
- W4283214294 cites W2060451852 @default.
- W4283214294 cites W2080264344 @default.
- W4283214294 cites W2080752012 @default.
- W4283214294 cites W2083914066 @default.
- W4283214294 cites W2095666785 @default.
- W4283214294 cites W2106595319 @default.
- W4283214294 cites W2110121929 @default.
- W4283214294 cites W2129898733 @default.
- W4283214294 cites W2159200529 @default.
- W4283214294 cites W2169589032 @default.
- W4283214294 cites W2209494116 @default.
- W4283214294 cites W2295873347 @default.
- W4283214294 cites W2315051190 @default.
- W4283214294 cites W2382031419 @default.
- W4283214294 cites W2402670290 @default.
- W4283214294 cites W2415462217 @default.
- W4283214294 cites W2426149297 @default.
- W4283214294 cites W2473765599 @default.
- W4283214294 cites W2509648701 @default.
- W4283214294 cites W2513683484 @default.
- W4283214294 cites W2553059650 @default.
- W4283214294 cites W2612767902 @default.
- W4283214294 cites W2741613455 @default.
- W4283214294 cites W2746710261 @default.
- W4283214294 cites W2763780391 @default.
- W4283214294 cites W2783749957 @default.
- W4283214294 cites W2790701366 @default.
- W4283214294 cites W2808305206 @default.
- W4283214294 cites W28584108 @default.
- W4283214294 cites W2909175659 @default.
- W4283214294 cites W2912300441 @default.
- W4283214294 cites W2934539266 @default.
- W4283214294 cites W2965592705 @default.
- W4283214294 cites W2995531566 @default.
- W4283214294 cites W3028320851 @default.
- W4283214294 cites W3036648835 @default.
- W4283214294 cites W3041932094 @default.
- W4283214294 cites W3129040296 @default.
- W4283214294 cites W3157747221 @default.
- W4283214294 cites W3165684196 @default.
- W4283214294 cites W3172640249 @default.
- W4283214294 cites W3193827842 @default.
- W4283214294 cites W3195719568 @default.
- W4283214294 cites W3195958678 @default.
- W4283214294 doi "https://doi.org/10.1002/btm2.10354" @default.