FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283215538> ?p ?o ?g. }

• W4283215538 abstract "Drug-target interactions (DTIs) are critical for drug repurposing and elucidation of drug mechanisms, and are manually curated by large databases, such as ChEMBL, BindingDB, DrugBank and DrugTargetCommons. However, the number of curated articles likely constitutes only a fraction of all the articles that contain experimentally determined DTIs. Finding such articles and extracting the experimental information is a challenging task, and there is a pressing need for systematic approaches to assist the curation of DTIs. To this end, we applied Bidirectional Encoder Representations from Transformers (BERT) to identify such articles. Because DTI data intimately depends on the type of assays used to generate it, we also aimed to incorporate functions to predict the assay format.Our novel method identified 0.6 million articles (along with drug and protein information) which are not previously included in public DTI databases. Using 10-fold cross-validation, we obtained ~ 99% accuracy for identifying articles containing quantitative drug-target profiles. The F1 micro for the prediction of assay format is 88%, which leaves room for improvement in future studies.The BERT model in this study is robust and the proposed pipeline can be used to identify previously overlooked articles containing quantitative DTIs. Overall, our method provides a significant advancement in machine-assisted DTI extraction and curation. We expect it to be a useful addition to drug mechanism discovery and repurposing." @default.
• W4283215538 created "2022-06-22" @default.
• W4283215538 creator A5025335008 @default.
• W4283215538 creator A5026730333 @default.
• W4283215538 creator A5083397767 @default.
• W4283215538 creator A5084617577 @default.
• W4283215538 date "2022-06-21" @default.
• W4283215538 modified "2023-10-09" @default.
• W4283215538 title "Using BERT to identify drug-target interactions from whole PubMed" @default.
• W4283215538 cites W1964670939 @default.
• W4283215538 cites W1968682237 @default.
• W4283215538 cites W1974475138 @default.
• W4283215538 cites W1980129409 @default.
• W4283215538 cites W2046379971 @default.
• W4283215538 cites W2074370114 @default.
• W4283215538 cites W2122590558 @default.
• W4283215538 cites W2152265294 @default.
• W4283215538 cites W2171757104 @default.
• W4283215538 cites W2204695023 @default.
• W4283215538 cites W2250539671 @default.
• W4283215538 cites W2279949369 @default.
• W4283215538 cites W2533611849 @default.
• W4283215538 cites W2537679995 @default.
• W4283215538 cites W2558366645 @default.
• W4283215538 cites W2558461040 @default.
• W4283215538 cites W2558999090 @default.
• W4283215538 cites W2777884179 @default.
• W4283215538 cites W2801930304 @default.
• W4283215538 cites W2890507936 @default.
• W4283215538 cites W2903953910 @default.
• W4283215538 cites W2911489562 @default.
• W4283215538 cites W2912942083 @default.
• W4283215538 cites W2913445039 @default.
• W4283215538 cites W2916534270 @default.
• W4283215538 cites W2935632020 @default.
• W4283215538 cites W2962739339 @default.
• W4283215538 cites W2963026768 @default.
• W4283215538 cites W2970771982 @default.
• W4283215538 cites W2971258845 @default.
• W4283215538 cites W2979826702 @default.
• W4283215538 cites W2980708516 @default.
• W4283215538 cites W2985843002 @default.
• W4283215538 cites W3000043291 @default.
• W4283215538 cites W3006508031 @default.
• W4283215538 cites W3015453090 @default.
• W4283215538 cites W3037553555 @default.
• W4283215538 cites W3039465695 @default.
• W4283215538 cites W3094217983 @default.
• W4283215538 cites W3123655913 @default.
• W4283215538 cites W3164680581 @default.
• W4283215538 cites W3195937938 @default.
• W4283215538 cites W3198396834 @default.
• W4283215538 cites W4210466552 @default.
• W4283215538 doi "https://doi.org/10.1186/s12859-022-04768-x" @default.
• W4283215538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35729494" @default.
• W4283215538 hasPublicationYear "2022" @default.
• W4283215538 type Work @default.
• W4283215538 citedByCount "5" @default.
• W4283215538 countsByYear W42832155382023 @default.
• W4283215538 crossrefType "journal-article" @default.
• W4283215538 hasAuthorship W4283215538A5025335008 @default.
• W4283215538 hasAuthorship W4283215538A5026730333 @default.
• W4283215538 hasAuthorship W4283215538A5083397767 @default.
• W4283215538 hasAuthorship W4283215538A5084617577 @default.
• W4283215538 hasBestOaLocation W42832155381 @default.
• W4283215538 hasConcept C103637391 @default.
• W4283215538 hasConcept C124101348 @default.
• W4283215538 hasConcept C155261790 @default.
• W4283215538 hasConcept C18903297 @default.
• W4283215538 hasConcept C199360897 @default.
• W4283215538 hasConcept C2777494893 @default.
• W4283215538 hasConcept C2780035454 @default.
• W4283215538 hasConcept C41008148 @default.
• W4283215538 hasConcept C43521106 @default.
• W4283215538 hasConcept C519536355 @default.
• W4283215538 hasConcept C60644358 @default.
• W4283215538 hasConcept C63222358 @default.
• W4283215538 hasConcept C70721500 @default.
• W4283215538 hasConcept C74187038 @default.
• W4283215538 hasConcept C86803240 @default.
• W4283215538 hasConcept C91632574 @default.
• W4283215538 hasConcept C98274493 @default.
• W4283215538 hasConceptScore W4283215538C103637391 @default.
• W4283215538 hasConceptScore W4283215538C124101348 @default.
• W4283215538 hasConceptScore W4283215538C155261790 @default.
• W4283215538 hasConceptScore W4283215538C18903297 @default.
• W4283215538 hasConceptScore W4283215538C199360897 @default.
• W4283215538 hasConceptScore W4283215538C2777494893 @default.
• W4283215538 hasConceptScore W4283215538C2780035454 @default.
• W4283215538 hasConceptScore W4283215538C41008148 @default.
• W4283215538 hasConceptScore W4283215538C43521106 @default.
• W4283215538 hasConceptScore W4283215538C519536355 @default.
• W4283215538 hasConceptScore W4283215538C60644358 @default.
• W4283215538 hasConceptScore W4283215538C63222358 @default.
• W4283215538 hasConceptScore W4283215538C70721500 @default.
• W4283215538 hasConceptScore W4283215538C74187038 @default.
• W4283215538 hasConceptScore W4283215538C86803240 @default.
• W4283215538 hasConceptScore W4283215538C91632574 @default.
• W4283215538 hasConceptScore W4283215538C98274493 @default.
• W4283215538 hasIssue "1" @default.

• next