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- W4283216625 abstract "Naturally occurring α-pyrones with biological activities are mostly synthesised by polyketide synthases (PKSs) via iterative decarboxylative Claisen condensation steps. Remarkably, we found that some enzymes related to the fatty acid β-oxidation pathway in Escherichia coli, namely the CoA ligase FadD and the thiolases FadA and FadI, can synthesise styrylpyrones with phenylpropionic acids in vivo. The two thiolases directly utilise acetyl-CoA as an extender unit for carbon-chain elongation through a non-decarboxylative Claisen condensation, thus making the overall reaction more efficient in terms of carbon and energy consumption. Moreover, using a cell-free approach, different styrylpyrones were synthesised in vitro. Finally, targeted feeding experiments led to the detection of styrylpyrones in other species, demonstrating that the intrinsic ability of the β-oxidation pathway allows for the synthesis of such molecules in bacteria, revealing an important biological feature hitherto neglected." @default.
- W4283216625 created "2022-06-22" @default.
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- W4283216625 date "2022-07-13" @default.
- W4283216625 modified "2023-10-14" @default.
- W4283216625 title "Intrinsic Ability of the β‐Oxidation Pathway To Produce Bioactive Styrylpyrones" @default.
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- W4283216625 doi "https://doi.org/10.1002/anie.202206851" @default.
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