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• W4283258635 abstract "RNA binding proteins mediate posttranscriptional RNA metabolism and play regulatory roles in many developmental processes in eukaryotes. Despite their known effects on the floral transition from vegetative to reproductive growth in plants, the underlying mechanisms remain largely obscure. Here, we show that a hitherto unknown RNA binding protein, hnRNP R-LIKE PROTEIN (HRLP), inhibits cotranscriptional splicing of a key floral repressor gene FLOWERING LOCUS C ( FLC ). This, in turn, facilitates R-loop formation near FLC intron I to repress its transcription, thereby promoting the floral transition in Arabidopsis thaliana . HRLP, together with the splicing factor ARGININE/SERINE-RICH 45, forms phase-separated nuclear condensates with liquid-like properties, which is essential for HRLP function in regulating FLC splicing, R-loop formation, and RNA Polymerase II recruitment. Our findings reveal that inhibition of cotranscriptional splicing of FLC by nuclear HRLP condensates constitutes the molecular basis for down-regulation of FLC transcript levels to ensure the reproductive success of Arabidopsis ." @default.
• W4283258635 created "2022-06-23" @default.
• W4283258635 creator A5006079431 @default.
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• W4283258635 date "2022-06-24" @default.
• W4283258635 modified "2023-10-18" @default.
• W4283258635 title "Phase separation of HRLP regulates flowering time in<i>Arabidopsis</i>" @default.
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• W4283258635 doi "https://doi.org/10.1126/sciadv.abn5488" @default.
• W4283258635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35731874" @default.
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