Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283260050> ?p ?o ?g. }
- W4283260050 endingPage "110988" @default.
- W4283260050 startingPage "110988" @default.
- W4283260050 abstract "MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1.2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. Removal of macroH2A1.2 and macroH2A2 in hepatoblastoma cells affects the contact frequency of promoters and distal enhancers coinciding with changes in enhancer activity or preceding them in response to the cytokine tumor necrosis factor alpha. Although macroH2As regulate genes in both directions, they globally facilitate the nuclear factor κB (NF-κB)-mediated response. In contrast, macroH2As suppress the response to the pro-inflammatory cytokine interferon gamma. MacroH2A2 has a stronger contribution to gene repression than macroH2A1.2. Taken together, our results suggest that macroH2As have a role in regulating the response of cancer cells to inflammatory signals on the level of chromatin structure. This is likely relevant for the interaction of cancer cells with immune cells of their microenvironment." @default.
- W4283260050 created "2022-06-23" @default.
- W4283260050 creator A5002559291 @default.
- W4283260050 creator A5003733187 @default.
- W4283260050 creator A5011797357 @default.
- W4283260050 creator A5016013425 @default.
- W4283260050 creator A5024209538 @default.
- W4283260050 creator A5027198746 @default.
- W4283260050 creator A5040145590 @default.
- W4283260050 creator A5045635830 @default.
- W4283260050 creator A5049006221 @default.
- W4283260050 creator A5050730834 @default.
- W4283260050 creator A5052232065 @default.
- W4283260050 creator A5060372672 @default.
- W4283260050 creator A5062604313 @default.
- W4283260050 creator A5067249637 @default.
- W4283260050 creator A5068062778 @default.
- W4283260050 creator A5075298669 @default.
- W4283260050 creator A5082048799 @default.
- W4283260050 creator A5083923541 @default.
- W4283260050 creator A5088125885 @default.
- W4283260050 creator A5090326016 @default.
- W4283260050 date "2022-06-01" @default.
- W4283260050 modified "2023-10-18" @default.
- W4283260050 title "MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines" @default.
- W4283260050 cites W1553586051 @default.
- W4283260050 cites W1582471009 @default.
- W4283260050 cites W1647232018 @default.
- W4283260050 cites W1700829084 @default.
- W4283260050 cites W1755602580 @default.
- W4283260050 cites W1895409307 @default.
- W4283260050 cites W1963549191 @default.
- W4283260050 cites W1967835379 @default.
- W4283260050 cites W1974768373 @default.
- W4283260050 cites W1975781002 @default.
- W4283260050 cites W1986639906 @default.
- W4283260050 cites W1988201936 @default.
- W4283260050 cites W2002670570 @default.
- W4283260050 cites W2005725169 @default.
- W4283260050 cites W2006659499 @default.
- W4283260050 cites W2019637656 @default.
- W4283260050 cites W2038356000 @default.
- W4283260050 cites W2042073539 @default.
- W4283260050 cites W2044524973 @default.
- W4283260050 cites W2061294496 @default.
- W4283260050 cites W2065055088 @default.
- W4283260050 cites W2074998492 @default.
- W4283260050 cites W2076154138 @default.
- W4283260050 cites W2083308605 @default.
- W4283260050 cites W2087476954 @default.
- W4283260050 cites W2108729723 @default.
- W4283260050 cites W2117692326 @default.
- W4283260050 cites W2126806930 @default.
- W4283260050 cites W2130193649 @default.
- W4283260050 cites W2130410032 @default.
- W4283260050 cites W2134907628 @default.
- W4283260050 cites W2143347171 @default.
- W4283260050 cites W2146512944 @default.
- W4283260050 cites W2148109525 @default.
- W4283260050 cites W2157569563 @default.
- W4283260050 cites W2158485828 @default.
- W4283260050 cites W2169567788 @default.
- W4283260050 cites W2170011016 @default.
- W4283260050 cites W2171503876 @default.
- W4283260050 cites W2172139203 @default.
- W4283260050 cites W2179438025 @default.
- W4283260050 cites W2214074259 @default.
- W4283260050 cites W2258223596 @default.
- W4283260050 cites W2303309927 @default.
- W4283260050 cites W2338415548 @default.
- W4283260050 cites W2465545880 @default.
- W4283260050 cites W2472255748 @default.
- W4283260050 cites W2481029670 @default.
- W4283260050 cites W2523285811 @default.
- W4283260050 cites W2564989217 @default.
- W4283260050 cites W2584444855 @default.
- W4283260050 cites W2592811885 @default.
- W4283260050 cites W2606675097 @default.
- W4283260050 cites W2744617457 @default.
- W4283260050 cites W2754792307 @default.
- W4283260050 cites W2785091318 @default.
- W4283260050 cites W2808981308 @default.
- W4283260050 cites W2810015912 @default.
- W4283260050 cites W2885101107 @default.
- W4283260050 cites W2889323361 @default.
- W4283260050 cites W2894168445 @default.
- W4283260050 cites W2934953754 @default.
- W4283260050 cites W2944340292 @default.
- W4283260050 cites W2951050465 @default.
- W4283260050 cites W2952391626 @default.
- W4283260050 cites W2952527196 @default.
- W4283260050 cites W2964315448 @default.
- W4283260050 cites W2993935374 @default.
- W4283260050 cites W3014801075 @default.
- W4283260050 cites W3021836082 @default.
- W4283260050 cites W3028304854 @default.
- W4283260050 cites W3042897759 @default.
- W4283260050 cites W3123330838 @default.