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- W4283261639 abstract "Mutations in optineurin/OPTN are associated with amyotrophic lateral sclerosis (ALS). To explore the role of OPTN in ALS pathogenesis, we used OPTN knockout mice. OPTN-deficient mice did not show kyphosis, loss of body weight, or reduction of front paw-grip strength or limb muscle strength. Our results suggest that OPTN deficiency alone is not sufficient to induce ALS-like symptoms in mice, and it may require cooperation with other genetic or environmental factors to cause ALS. OPTN-deficient mice showed patchy hair loss (alopecia), which increased with age, and higher percentage of CD8-positive T cells in the blood." @default.
- W4283261639 created "2022-06-23" @default.
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- W4283261639 date "2022-10-01" @default.
- W4283261639 modified "2023-10-13" @default.
- W4283261639 title "Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice" @default.
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- W4283261639 doi "https://doi.org/10.1016/j.bbadis.2022.166470" @default.
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