Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283262471> ?p ?o ?g. }
- W4283262471 endingPage "3038" @default.
- W4283262471 startingPage "3038" @default.
- W4283262471 abstract "Persistent infection with Human papillomavirus (HPV) is the main etiologic factor for pre-malignant and malignant cervical lesions. Moreover, HPV is also associated with oropharynx and other anogenital carcinomas. Cancer-causing HPV viruses classified as group 1 carcinogens include 12 HPV types, with HPV 16 and 18 being the most prevalent. High-risk HPVs express two oncoproteins, E6 and E7, the products of which are responsible for the inhibition of p53 and pRB proteins, respectively, in human keratinocytes and cellular immortalization. p53 and pRB are pleiotropic proteins that regulate the activity of several signaling pathways and gene expression. Among the important factors that are augmented in HPV-mediated carcinogenesis, proteases not only control processes involved in cellular carcinogenesis but also control the microenvironment. For instance, genetic polymorphisms of matrix metalloproteinase 1 (MMP-1) are associated with carcinoma invasiveness. Similarly, the serine protease inhibitors hepatocyte growth factor activator inhibitor-1 (HAI-1) and -2 (HAI-2) have been identified as prognostic markers for HPV-dependent cervical carcinomas. This review highlights the most crucial mechanisms involved in HPV-dependent carcinogenesis, and includes a section on the proteolytic cascades that are important for the progression of this disease and their impact on patient health, treatment, and survival." @default.
- W4283262471 created "2022-06-23" @default.
- W4283262471 creator A5023204981 @default.
- W4283262471 creator A5029073569 @default.
- W4283262471 creator A5033614009 @default.
- W4283262471 creator A5034852834 @default.
- W4283262471 creator A5054355513 @default.
- W4283262471 creator A5054642897 @default.
- W4283262471 creator A5077227987 @default.
- W4283262471 creator A5079951344 @default.
- W4283262471 date "2022-06-21" @default.
- W4283262471 modified "2023-10-18" @default.
- W4283262471 title "Proteases and HPV-Induced Carcinogenesis" @default.
- W4283262471 cites W1020082051 @default.
- W4283262471 cites W111537229 @default.
- W4283262471 cites W1255113054 @default.
- W4283262471 cites W1547311172 @default.
- W4283262471 cites W1555312557 @default.
- W4283262471 cites W1575243854 @default.
- W4283262471 cites W1586491683 @default.
- W4283262471 cites W1594464537 @default.
- W4283262471 cites W1640570245 @default.
- W4283262471 cites W173927235 @default.
- W4283262471 cites W1796640198 @default.
- W4283262471 cites W1844381769 @default.
- W4283262471 cites W1891221278 @default.
- W4283262471 cites W1901126754 @default.
- W4283262471 cites W1911799966 @default.
- W4283262471 cites W1925793786 @default.
- W4283262471 cites W1930593116 @default.
- W4283262471 cites W1937375640 @default.
- W4283262471 cites W1941278354 @default.
- W4283262471 cites W1964128146 @default.
- W4283262471 cites W1964802599 @default.
- W4283262471 cites W1964927845 @default.
- W4283262471 cites W1966845438 @default.
- W4283262471 cites W1967860838 @default.
- W4283262471 cites W1970159404 @default.
- W4283262471 cites W1972535275 @default.
- W4283262471 cites W1972825102 @default.
- W4283262471 cites W1973571261 @default.
- W4283262471 cites W1975168196 @default.
- W4283262471 cites W1977741512 @default.
- W4283262471 cites W1979863928 @default.
- W4283262471 cites W1980314091 @default.
- W4283262471 cites W1980377336 @default.
- W4283262471 cites W1980437003 @default.
- W4283262471 cites W1980792888 @default.
- W4283262471 cites W1981519675 @default.
- W4283262471 cites W1982149110 @default.
- W4283262471 cites W1982342760 @default.
- W4283262471 cites W1983348452 @default.
- W4283262471 cites W1984418432 @default.
- W4283262471 cites W1985729537 @default.
- W4283262471 cites W1986062683 @default.
- W4283262471 cites W1986241711 @default.
- W4283262471 cites W1994970360 @default.
- W4283262471 cites W1996196320 @default.
- W4283262471 cites W1999720536 @default.
- W4283262471 cites W2002115764 @default.
- W4283262471 cites W2005367766 @default.
- W4283262471 cites W2005777124 @default.
- W4283262471 cites W2006996087 @default.
- W4283262471 cites W2008750108 @default.
- W4283262471 cites W2008958654 @default.
- W4283262471 cites W2009933647 @default.
- W4283262471 cites W2009972285 @default.
- W4283262471 cites W2013639959 @default.
- W4283262471 cites W2017108629 @default.
- W4283262471 cites W2017517248 @default.
- W4283262471 cites W2017558201 @default.
- W4283262471 cites W2020117426 @default.
- W4283262471 cites W2021098045 @default.
- W4283262471 cites W2026866444 @default.
- W4283262471 cites W2026884055 @default.
- W4283262471 cites W2028068087 @default.
- W4283262471 cites W2033350358 @default.
- W4283262471 cites W2033713678 @default.
- W4283262471 cites W2034496567 @default.
- W4283262471 cites W2035095394 @default.
- W4283262471 cites W2035221730 @default.
- W4283262471 cites W2039745983 @default.
- W4283262471 cites W2040386655 @default.
- W4283262471 cites W2040927104 @default.
- W4283262471 cites W2044680553 @default.
- W4283262471 cites W2046022222 @default.
- W4283262471 cites W2047159073 @default.
- W4283262471 cites W2047337285 @default.
- W4283262471 cites W2048792376 @default.
- W4283262471 cites W2049949004 @default.
- W4283262471 cites W2050664909 @default.
- W4283262471 cites W2053892145 @default.
- W4283262471 cites W2055177313 @default.
- W4283262471 cites W2056373000 @default.
- W4283262471 cites W2057633567 @default.
- W4283262471 cites W2058960706 @default.
- W4283262471 cites W2060900304 @default.
- W4283262471 cites W2061793135 @default.