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- W4283262501 abstract "Targeted delivery of therapeutic drugs is essential for precise treatment of various diseases to reduce possible serious side-effects. A screened DNA aptamer has been widely developed for active targeting delivery. Herein, we report a facile strategy for the construction of a branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery. In our design, the terminal-modified DNA aptamer can be covalently conjugated to form a branched aptamer cluster by click reaction easily. The branched aptamer cluster-modified DNA tetrahedron (TET) demonstrates highly targeted cellular uptake with the modification of only one site. After loading the chemotherapeutic drug (doxorubicin, DOX), the DNA aptamer cluster-based nanoplatform elicits a remarkable and selective inhibition of tumor cell proliferation by much-enhanced targeted delivery. This covalently conjugated branched DNA aptamer cluster-based nanoplatform provides a new strategy for the development of targeted drug delivery." @default.
- W4283262501 created "2022-06-23" @default.
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- W4283262501 date "2022-01-01" @default.
- W4283262501 modified "2023-10-14" @default.
- W4283262501 title "A covalently conjugated branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery" @default.
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- W4283262501 doi "https://doi.org/10.1039/d2nr01252a" @default.
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