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- W4283264832 endingPage "818" @default.
- W4283264832 startingPage "809" @default.
- W4283264832 abstract "Despite compartmentalization within the lumen of the gastrointestinal tract, the gut microbiota has a far-reaching influence on immune cell development and function throughout the body. This long-distance relationship is crucial for immune homeostasis, including effective host defense against invading pathogens that cause systemic infections. Herein, we review new insights into how commensal microbes that are spatially restricted to the gut lumen can engage in long-distance relationships with innate and adaptive immune cells at systemic sites to fortify host defenses against infections. In addition, we explore the consequences of intestinal dysbiosis on impaired host defense and immune-mediated pathology during infections, including emerging evidence linking dysbiosis with aberrant systemic inflammation and immune-mediated organ damage in sepsis. As such, therapeutic modification of the gut microbiota is an emerging target for interventions to prevent and/or treat systemic infections and sepsis by harnessing the long-distance relationships between gut microbes and systemic immunity." @default.
- W4283264832 created "2022-06-23" @default.
- W4283264832 creator A5001063003 @default.
- W4283264832 creator A5067524442 @default.
- W4283264832 creator A5082234944 @default.
- W4283264832 creator A5084451221 @default.
- W4283264832 date "2022-08-01" @default.
- W4283264832 modified "2023-10-14" @default.
- W4283264832 title "Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota" @default.
- W4283264832 cites W1515023627 @default.
- W4283264832 cites W1563758529 @default.
- W4283264832 cites W1566458213 @default.
- W4283264832 cites W1649651531 @default.
- W4283264832 cites W1789863752 @default.
- W4283264832 cites W1907515023 @default.
- W4283264832 cites W1912150073 @default.
- W4283264832 cites W1912521894 @default.
- W4283264832 cites W1948473898 @default.
- W4283264832 cites W1951711480 @default.
- W4283264832 cites W1954074998 @default.
- W4283264832 cites W1979573684 @default.
- W4283264832 cites W1980737419 @default.
- W4283264832 cites W1993830991 @default.
- W4283264832 cites W1995355078 @default.
- W4283264832 cites W1998653357 @default.
- W4283264832 cites W2007910255 @default.
- W4283264832 cites W2016415226 @default.
- W4283264832 cites W2031634435 @default.
- W4283264832 cites W2036484015 @default.
- W4283264832 cites W2043221884 @default.
- W4283264832 cites W2052884083 @default.
- W4283264832 cites W2054241879 @default.
- W4283264832 cites W2056386675 @default.
- W4283264832 cites W2066382988 @default.
- W4283264832 cites W2069368135 @default.
- W4283264832 cites W2072417345 @default.
- W4283264832 cites W2087495887 @default.
- W4283264832 cites W2107369528 @default.
- W4283264832 cites W2108978157 @default.
- W4283264832 cites W2109357160 @default.
- W4283264832 cites W2110957620 @default.
- W4283264832 cites W2112671019 @default.
- W4283264832 cites W2120522976 @default.
- W4283264832 cites W2122379614 @default.
- W4283264832 cites W2128109029 @default.
- W4283264832 cites W2133756317 @default.
- W4283264832 cites W2134617060 @default.
- W4283264832 cites W2134928825 @default.
- W4283264832 cites W2139284253 @default.
- W4283264832 cites W2141759041 @default.
- W4283264832 cites W2156601383 @default.
- W4283264832 cites W2159913536 @default.
- W4283264832 cites W2161868263 @default.
- W4283264832 cites W2164342861 @default.
- W4283264832 cites W2164386968 @default.
- W4283264832 cites W2165067288 @default.
- W4283264832 cites W2168842536 @default.
- W4283264832 cites W2172687959 @default.
- W4283264832 cites W2175017347 @default.
- W4283264832 cites W2175568660 @default.
- W4283264832 cites W2285543512 @default.
- W4283264832 cites W2289780567 @default.
- W4283264832 cites W2290181911 @default.
- W4283264832 cites W2295213040 @default.
- W4283264832 cites W2393330052 @default.
- W4283264832 cites W2412773516 @default.
- W4283264832 cites W2416919318 @default.
- W4283264832 cites W2467146152 @default.
- W4283264832 cites W2469218097 @default.
- W4283264832 cites W2491805933 @default.
- W4283264832 cites W2496661162 @default.
- W4283264832 cites W2510684933 @default.
- W4283264832 cites W2510962849 @default.
- W4283264832 cites W2513746620 @default.
- W4283264832 cites W2516525774 @default.
- W4283264832 cites W2525351830 @default.
- W4283264832 cites W2548957578 @default.
- W4283264832 cites W2586384338 @default.
- W4283264832 cites W2605952725 @default.
- W4283264832 cites W2613928270 @default.
- W4283264832 cites W2744280559 @default.
- W4283264832 cites W2759933576 @default.
- W4283264832 cites W2763044321 @default.
- W4283264832 cites W2765195199 @default.
- W4283264832 cites W2765424888 @default.
- W4283264832 cites W2769536540 @default.
- W4283264832 cites W2770311021 @default.
- W4283264832 cites W2788708935 @default.
- W4283264832 cites W2791770850 @default.
- W4283264832 cites W2795362564 @default.
- W4283264832 cites W2799300982 @default.
- W4283264832 cites W2800345920 @default.
- W4283264832 cites W2802205848 @default.
- W4283264832 cites W2803013275 @default.
- W4283264832 cites W2803398082 @default.
- W4283264832 cites W2803953825 @default.
- W4283264832 cites W2809017655 @default.
- W4283264832 cites W2810245133 @default.