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- W4283265209 abstract "Abstract Background: Group 2 innate lymphoid cells (ILC2s) are the most dominant ILCs in heart tissue, sex-related differences exist in mouse lung ILC2 phenotypes and functions; however, it is still unclear whether there are sex differences in heart ILC2s. Results: Compared with age-matched wild-type (WT) male mice, 8-week-old but not 3 week-old WT female mice harbored an obviously greater percentage and number of heart ILC2s in homeostasis present. However, the percentage of killer-cell lectin-like receptor G1 (Klrg1) - ILC2s were higher but the Klrg1 + ILC2s were lower in female mice than in male mice in both the heart tissue of 3- and 8-week-old mice. Eight-week-old Rag2 -/- mice also showed sex differences similar to those of age-matched WT mice. Regarding surface marker expression, compared to age-matched male mice, WT female mice showed higher expression of CD90.2, and lower expression of Klrg1 and Sca-1 in heart total ILC2s. No sex difference in IL-4 and IL-5 secretion by male and female mice heart ILC2s. Increased IL-33 mRNA levels within the heart tissues were also found in female mice compared with male mice. Conclusions: These results have revealed the greater numbers of ILC2s, higher expression of CD90.2, reduced Klrg1 and Sca-1 expression in the heart of female mice than male mice and no sex difference in IL-4 and IL-5 production in male and female mice heart ILC2s. These sex differences of heart ILC2s might be due to the heterogeneity of IL-33 within the heart tissue." @default.
- W4283265209 created "2022-06-23" @default.
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- W4283265209 date "2022-06-22" @default.
- W4283265209 modified "2023-10-16" @default.
- W4283265209 title "Sex differences exist in adult heart group 2 innate lymphoid cells" @default.
- W4283265209 doi "https://doi.org/10.21203/rs.3.rs-1765137/v1" @default.
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