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- W4283267244 abstract "Five new polycyclic polyprenylated acylphloroglucinols (1-5), ascyrones A-E, and four known compounds (6-9) were isolated from the aerial parts of Hypericum ascyron. All of the isolates containing a bicyclo[3.3.1]nonane-2,4,9-trione core and a benzoyl group, belonged to type B bicyclic polyprenylated acylphloroglucinols (BPAPs). Their structures and absolute configurations were established based on spectroscopic analyses and calculated electronic circular dichroism (ECD) data. The anti-inflammatory, neuroprotective and cytotoxicity activities of compounds 1-4 and 6-9 were evaluated. Compound 6 exhibited obvious anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 cells. Compounds 1 and 9 exhibited slight cytotoxicity against Hep3B cells. Meanwhile, compound 1 showed mild neuroprotective activity against corticosterone (CORT)-induced PC12 cell damage at 10 μmol·L-1." @default.
- W4283267244 created "2022-06-23" @default.
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- W4283267244 date "2022-06-01" @default.
- W4283267244 modified "2023-10-16" @default.
- W4283267244 title "Ascyrones A–E, type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron" @default.
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- W4283267244 doi "https://doi.org/10.1016/s1875-5364(22)60167-5" @default.
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