Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283270412> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4283270412 abstract "Abstract Background It is unknown whether the early renal replacement therapy (RRT) initiation strategy in intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) and sepsis with or without renal failure provides clinical benefit. Patients and methods: A total of 745 patients with ARDS complicated by sepsis admitted to the ICU of Tianjin Medical University General Hospital were included in the analysis. Early RRT was defined as initiating the RRT strategy within 24 hours of admission. The relationship between early RRT and clinical outcomes, including primary (30-day mortality) and secondary (90-day mortality, serum creatinine level, oxygenation index, duration of invasive mechanical ventilation, cumulative fluid output, and cumulative fluid balance), was primarily compared using propensity score matching (PSM). Results A total of 263 patients (35.3% of the total population) received an early RRT initiation strategy before PSM. After PSM, a cohort of 130 patients with early CRRT and 130 patients without early CRRT with matched baseline characteristics was constructed. Early RRT was not significantly associated with 30- [hazard ratio (HR): 1.37, 95%CI: 0.91–2.06, P = 0.127] or 90-day mortality (HR: 1.29, 95%CI: 0.89–1.88, P = 0.182). At each time point within 72 hours after admission, there was no significant difference in oxygenation index and duration of invasive mechanical ventilation between the early RRT group and the no early RRT group. Early RRT significantly increased total output at all time points within 72 h of admission but only reached a statistically significant negative fluid balance at 72 h ( P = 0.016). Conclusions Early RRT initiation strategies had no statistically significant survival benefit in ICU patients with ARDS and sepsis, with or without renal failure, nor did they significantly improve oxygenation or shorten the duration of mechanical ventilation. The use and timing of RRT in these patients should be thoroughly investigated." @default.
- W4283270412 created "2022-06-23" @default.
- W4283270412 creator A5006645827 @default.
- W4283270412 creator A5051669215 @default.
- W4283270412 creator A5060962435 @default.
- W4283270412 creator A5063905782 @default.
- W4283270412 creator A5072976743 @default.
- W4283270412 creator A5073746039 @default.
- W4283270412 date "2022-06-21" @default.
- W4283270412 modified "2023-10-18" @default.
- W4283270412 title "Early Initiation of Renal Replacement Therapy in Intensive Care Unit Patients with Acute Respiratory Distress Syndrome and Sepsis with or without Renal Failure: A Retrospective Cohort Study Based on Propensity Score Matching" @default.
- W4283270412 doi "https://doi.org/10.21203/rs.3.rs-1730069/v2" @default.
- W4283270412 hasPublicationYear "2022" @default.
- W4283270412 type Work @default.
- W4283270412 citedByCount "0" @default.
- W4283270412 crossrefType "posted-content" @default.
- W4283270412 hasAuthorship W4283270412A5006645827 @default.
- W4283270412 hasAuthorship W4283270412A5051669215 @default.
- W4283270412 hasAuthorship W4283270412A5060962435 @default.
- W4283270412 hasAuthorship W4283270412A5063905782 @default.
- W4283270412 hasAuthorship W4283270412A5072976743 @default.
- W4283270412 hasAuthorship W4283270412A5073746039 @default.
- W4283270412 hasBestOaLocation W42832704121 @default.
- W4283270412 hasConcept C126322002 @default.
- W4283270412 hasConcept C167135981 @default.
- W4283270412 hasConcept C17923572 @default.
- W4283270412 hasConcept C207103383 @default.
- W4283270412 hasConcept C2776348555 @default.
- W4283270412 hasConcept C2776376669 @default.
- W4283270412 hasConcept C2777080012 @default.
- W4283270412 hasConcept C2777714996 @default.
- W4283270412 hasConcept C2778384902 @default.
- W4283270412 hasConcept C2779541074 @default.
- W4283270412 hasConcept C2779978075 @default.
- W4283270412 hasConcept C2780472472 @default.
- W4283270412 hasConcept C2908647359 @default.
- W4283270412 hasConcept C44249647 @default.
- W4283270412 hasConcept C71924100 @default.
- W4283270412 hasConcept C99454951 @default.
- W4283270412 hasConceptScore W4283270412C126322002 @default.
- W4283270412 hasConceptScore W4283270412C167135981 @default.
- W4283270412 hasConceptScore W4283270412C17923572 @default.
- W4283270412 hasConceptScore W4283270412C207103383 @default.
- W4283270412 hasConceptScore W4283270412C2776348555 @default.
- W4283270412 hasConceptScore W4283270412C2776376669 @default.
- W4283270412 hasConceptScore W4283270412C2777080012 @default.
- W4283270412 hasConceptScore W4283270412C2777714996 @default.
- W4283270412 hasConceptScore W4283270412C2778384902 @default.
- W4283270412 hasConceptScore W4283270412C2779541074 @default.
- W4283270412 hasConceptScore W4283270412C2779978075 @default.
- W4283270412 hasConceptScore W4283270412C2780472472 @default.
- W4283270412 hasConceptScore W4283270412C2908647359 @default.
- W4283270412 hasConceptScore W4283270412C44249647 @default.
- W4283270412 hasConceptScore W4283270412C71924100 @default.
- W4283270412 hasConceptScore W4283270412C99454951 @default.
- W4283270412 hasLocation W42832704121 @default.
- W4283270412 hasOpenAccess W4283270412 @default.
- W4283270412 hasPrimaryLocation W42832704121 @default.
- W4283270412 hasRelatedWork W1479774898 @default.
- W4283270412 hasRelatedWork W1998866815 @default.
- W4283270412 hasRelatedWork W2014956456 @default.
- W4283270412 hasRelatedWork W2063317977 @default.
- W4283270412 hasRelatedWork W2230199712 @default.
- W4283270412 hasRelatedWork W2604566494 @default.
- W4283270412 hasRelatedWork W2956110815 @default.
- W4283270412 hasRelatedWork W3014075454 @default.
- W4283270412 hasRelatedWork W3091759781 @default.
- W4283270412 hasRelatedWork W3158839732 @default.
- W4283270412 isParatext "false" @default.
- W4283270412 isRetracted "false" @default.
- W4283270412 workType "article" @default.