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- W4283270911 abstract "Abstract Background In recent years, many research groups have attempted to identify a subgroup of “ultra‐high risk” patients within the high‐risk neuroblastoma (NB) category. The aim of our study was to evaluate the prognostic significance of parameters derived from pretherapeutic 123 I‐meta‐iodobenzylguanidine ([ 123 I]mIBG) integrated single photon emission computed tomography and computed tomography in high‐risk patients with NB. Methods The established parameters metabolic tumor volume (MTV), maximal standardized uptake value (SUV max ) and the novel parameter tumor asphericity as well as clinical (age, stage) and genetic factors (1p/11q deletions and MYCN amplification) were analyzed in this single‐center retrospective study of high‐risk patients with newly diagnosed NB. Univariate/multivariable Cox regression and propensity score matching were performed for clinical and radiological parameters. Results Twenty‐eight high‐risk patients with NB were included (14 males, median age 28.8 (11.3–41.0), range 3–74 months). Multivariable analysis of “full” cohort identified high asphericity (≥65%, adjusted hazard ratio [HR] 5.32, 95% confidence interval [CI]: 1.18–24.07, p = .03) and MTV (≥50 ml, adjusted HR 4.31, 95% CI: 1.18–15.80, p = .027) as the only factors associated with worse event‐free survival. In matched cohort, tumor asphericity was a significant predictor of relapse/progression (HR 3.83, 95% CI: 1.03–14.26, p = .046). Conclusion In this exploratory study, imaging parameters related to tumor metabolic activity, tumor asphericity and MTV, provided prognostic value for event‐free survival in high‐risk NB patients. Asphericity ≥65% and MTV ≥50 ml may serve as additional prognostic factors to those already used." @default.
- W4283270911 created "2022-06-23" @default.
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- W4283270911 date "2022-06-23" @default.
- W4283270911 modified "2023-10-02" @default.
- W4283270911 title "Asphericity of tumor [<sup>123</sup>I]mIBG uptake as a prognostic factor in high‐risk neuroblastoma" @default.
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- W4283270911 doi "https://doi.org/10.1002/pbc.29849" @default.
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