Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283271285> ?p ?o ?g. }
- W4283271285 endingPage "106326" @default.
- W4283271285 startingPage "106326" @default.
- W4283271285 abstract "Diabetes is a major public health disease that is globally approaching epidemic proportions. One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin action which is usually caused by a combination of genetic and environmental factors. Not only these factors but others such as deregulation of various pathways, and oxidative stress are also known to trigger the redox imbalance in diabetics. Increasing evidences suggest that there are tight interactions between the development of diabetes and redox imbalance. An alternate pathway of glucose metabolism, the polyol pathway, becomes active in patients with diabetes that disturbs the balance between NADH and NAD+ . The occurrence of such redox imbalance supports other pathways that lead to oxidative damage to DNA, lipids, and proteins and consequently to oxidative stress which further ascend diabetes and its complications. However, the precise mechanism through which oxidative stress regulates diabetes progression remains to be elucidated. The understanding of how antioxidants and oxidants are controlled and impact the generation of oxidative stress and progression of diabetes is essential. The main focus of this review is to provide an overview of redox imbalance caused by oxidative stress through the polyol pathway. Understanding the pathological role of oxidative stress in diabetes will help to design potential therapeutic strategies against diabetes." @default.
- W4283271285 created "2022-06-23" @default.
- W4283271285 creator A5026347802 @default.
- W4283271285 creator A5058816518 @default.
- W4283271285 date "2022-08-01" @default.
- W4283271285 modified "2023-10-18" @default.
- W4283271285 title "Polyol pathway and redox balance in diabetes" @default.
- W4283271285 cites W1207588145 @default.
- W4283271285 cites W151010073 @default.
- W4283271285 cites W1529592271 @default.
- W4283271285 cites W1618818749 @default.
- W4283271285 cites W1757834753 @default.
- W4283271285 cites W1963449298 @default.
- W4283271285 cites W1970022476 @default.
- W4283271285 cites W1970554352 @default.
- W4283271285 cites W1970680007 @default.
- W4283271285 cites W1971448178 @default.
- W4283271285 cites W1973433561 @default.
- W4283271285 cites W1979216890 @default.
- W4283271285 cites W1982611758 @default.
- W4283271285 cites W1986366581 @default.
- W4283271285 cites W1996337164 @default.
- W4283271285 cites W1999647730 @default.
- W4283271285 cites W2007107430 @default.
- W4283271285 cites W2008887287 @default.
- W4283271285 cites W2010631790 @default.
- W4283271285 cites W2012886938 @default.
- W4283271285 cites W2013159801 @default.
- W4283271285 cites W2014829681 @default.
- W4283271285 cites W2016654742 @default.
- W4283271285 cites W2025639892 @default.
- W4283271285 cites W2026365242 @default.
- W4283271285 cites W2028178274 @default.
- W4283271285 cites W2028644941 @default.
- W4283271285 cites W2040625305 @default.
- W4283271285 cites W2041493424 @default.
- W4283271285 cites W2047053631 @default.
- W4283271285 cites W2048748542 @default.
- W4283271285 cites W2064483915 @default.
- W4283271285 cites W2065910339 @default.
- W4283271285 cites W2066290187 @default.
- W4283271285 cites W2066746672 @default.
- W4283271285 cites W2070927097 @default.
- W4283271285 cites W2071095951 @default.
- W4283271285 cites W2073134613 @default.
- W4283271285 cites W2074712105 @default.
- W4283271285 cites W2080841777 @default.
- W4283271285 cites W2086667809 @default.
- W4283271285 cites W2091008007 @default.
- W4283271285 cites W2097487849 @default.
- W4283271285 cites W2099541076 @default.
- W4283271285 cites W2105731956 @default.
- W4283271285 cites W2106561187 @default.
- W4283271285 cites W2113273759 @default.
- W4283271285 cites W2115337518 @default.
- W4283271285 cites W2120293565 @default.
- W4283271285 cites W2122226194 @default.
- W4283271285 cites W2124476733 @default.
- W4283271285 cites W2124488542 @default.
- W4283271285 cites W2124995126 @default.
- W4283271285 cites W2125733720 @default.
- W4283271285 cites W2133022777 @default.
- W4283271285 cites W2136913126 @default.
- W4283271285 cites W2137616809 @default.
- W4283271285 cites W2137923596 @default.
- W4283271285 cites W2143902746 @default.
- W4283271285 cites W2151269150 @default.
- W4283271285 cites W2152656461 @default.
- W4283271285 cites W2152875073 @default.
- W4283271285 cites W2153363369 @default.
- W4283271285 cites W2159021220 @default.
- W4283271285 cites W2167543749 @default.
- W4283271285 cites W2170672009 @default.
- W4283271285 cites W2193925571 @default.
- W4283271285 cites W2207316462 @default.
- W4283271285 cites W2269235343 @default.
- W4283271285 cites W2308938068 @default.
- W4283271285 cites W2361562022 @default.
- W4283271285 cites W2486397717 @default.
- W4283271285 cites W2572954835 @default.
- W4283271285 cites W2591962841 @default.
- W4283271285 cites W2592503444 @default.
- W4283271285 cites W2626543431 @default.
- W4283271285 cites W2635415917 @default.
- W4283271285 cites W2745230880 @default.
- W4283271285 cites W2756208820 @default.
- W4283271285 cites W2763925507 @default.
- W4283271285 cites W2767188829 @default.
- W4283271285 cites W2780780868 @default.
- W4283271285 cites W2785515118 @default.
- W4283271285 cites W2800038406 @default.
- W4283271285 cites W2805386022 @default.
- W4283271285 cites W2807436351 @default.
- W4283271285 cites W2891614594 @default.
- W4283271285 cites W2902683674 @default.
- W4283271285 cites W2907542103 @default.
- W4283271285 cites W2911549495 @default.
- W4283271285 cites W2966201789 @default.