Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283271519> ?p ?o ?g. }
- W4283271519 endingPage "601" @default.
- W4283271519 startingPage "590" @default.
- W4283271519 abstract "Inflammation is a cancer hallmark. Nonsteroidal anti-inflammatory drugs (NSAIDs) improve overall survival (OS) in certain cancers. Real-world studies explored here if NSAIDs improve non-small cell lung cancer (NSCLC) OS. Analyses independently interrogated clinical databases from The University of Texas MD Anderson Cancer Center (MDACC cohort, 1987 to 2015; 33,162 NSCLCs and 3,033 NSAID users) and Georgetown-MedStar health system (Georgetown cohort, 2000 to 2019; 4,497 NSCLCs and 1,993 NSAID users). Structured and unstructured clinical data were extracted from electronic health records (EHRs) using natural language processing (NLP). Associations were made between NSAID use and NSCLC prognostic features (tobacco use, gender, race, and body mass index, BMI). NSAIDs were statistically-significantly (P < 0.0001) associated with increased NSCLC survival (5-year OS 29.7% for NSAID users versus 13.1% for non-users) in the MDACC cohort. NSAID users gained 11.6 months over nonusers in 5-year restricted mean survival time. Stratified analysis by stage, histopathology and multicovariable assessment substantiated benefits. NSAID users were pooled independent of NSAID type and by NSAID type. Landmark analysis excluded immortal time bias. Survival improvements (P < 0.0001) were confirmed in the Georgetown cohort. Thus, real-world NSAID usage was independently associated with increased NSCLC survival in the MDACC and Georgetown cohorts. Findings were confirmed by landmark analyses and NSAID type. The OS benefits persisted despite tobacco use and did not depend on gender, race, or BMI (MDACC cohort, P < 0.0001). These real-world findings could guide future NSAID lung cancer randomized trials." @default.
- W4283271519 created "2022-06-23" @default.
- W4283271519 creator A5027438799 @default.
- W4283271519 creator A5027998671 @default.
- W4283271519 creator A5034362700 @default.
- W4283271519 creator A5035961942 @default.
- W4283271519 creator A5037218810 @default.
- W4283271519 creator A5041570474 @default.
- W4283271519 creator A5065839430 @default.
- W4283271519 creator A5080648304 @default.
- W4283271519 creator A5083247969 @default.
- W4283271519 creator A5084086047 @default.
- W4283271519 creator A5086058658 @default.
- W4283271519 creator A5091028729 @default.
- W4283271519 date "2022-07-06" @default.
- W4283271519 modified "2023-09-26" @default.
- W4283271519 title "Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival" @default.
- W4283271519 cites W1965037168 @default.
- W4283271519 cites W1967474254 @default.
- W4283271519 cites W1975076018 @default.
- W4283271519 cites W1982248155 @default.
- W4283271519 cites W1993497779 @default.
- W4283271519 cites W1993718861 @default.
- W4283271519 cites W2014229457 @default.
- W4283271519 cites W2022452291 @default.
- W4283271519 cites W2026387101 @default.
- W4283271519 cites W2033459915 @default.
- W4283271519 cites W2037952228 @default.
- W4283271519 cites W2076334024 @default.
- W4283271519 cites W2083431979 @default.
- W4283271519 cites W2088035579 @default.
- W4283271519 cites W2111714917 @default.
- W4283271519 cites W2114039834 @default.
- W4283271519 cites W2120169362 @default.
- W4283271519 cites W2134234269 @default.
- W4283271519 cites W2140481652 @default.
- W4283271519 cites W2151036184 @default.
- W4283271519 cites W2153825864 @default.
- W4283271519 cites W2173069051 @default.
- W4283271519 cites W2178187880 @default.
- W4283271519 cites W2202349529 @default.
- W4283271519 cites W2331422116 @default.
- W4283271519 cites W2332455909 @default.
- W4283271519 cites W2442550037 @default.
- W4283271519 cites W2515969222 @default.
- W4283271519 cites W2563062353 @default.
- W4283271519 cites W2593865959 @default.
- W4283271519 cites W2610163299 @default.
- W4283271519 cites W2619495471 @default.
- W4283271519 cites W2749312470 @default.
- W4283271519 cites W2769851464 @default.
- W4283271519 cites W2797407068 @default.
- W4283271519 cites W2884860771 @default.
- W4283271519 cites W2898518424 @default.
- W4283271519 cites W2911188335 @default.
- W4283271519 cites W2911961710 @default.
- W4283271519 cites W2921518676 @default.
- W4283271519 cites W2930328448 @default.
- W4283271519 cites W2944816116 @default.
- W4283271519 cites W2954119898 @default.
- W4283271519 cites W2967056613 @default.
- W4283271519 cites W2990271277 @default.
- W4283271519 cites W3006019089 @default.
- W4283271519 cites W814655059 @default.
- W4283271519 doi "https://doi.org/10.1158/2767-9764.crc-22-0179" @default.
- W4283271519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35832288" @default.
- W4283271519 hasPublicationYear "2022" @default.
- W4283271519 type Work @default.
- W4283271519 citedByCount "1" @default.
- W4283271519 countsByYear W42832715192023 @default.
- W4283271519 crossrefType "journal-article" @default.
- W4283271519 hasAuthorship W4283271519A5027438799 @default.
- W4283271519 hasAuthorship W4283271519A5027998671 @default.
- W4283271519 hasAuthorship W4283271519A5034362700 @default.
- W4283271519 hasAuthorship W4283271519A5035961942 @default.
- W4283271519 hasAuthorship W4283271519A5037218810 @default.
- W4283271519 hasAuthorship W4283271519A5041570474 @default.
- W4283271519 hasAuthorship W4283271519A5065839430 @default.
- W4283271519 hasAuthorship W4283271519A5080648304 @default.
- W4283271519 hasAuthorship W4283271519A5083247969 @default.
- W4283271519 hasAuthorship W4283271519A5084086047 @default.
- W4283271519 hasAuthorship W4283271519A5086058658 @default.
- W4283271519 hasAuthorship W4283271519A5091028729 @default.
- W4283271519 hasBestOaLocation W42832715191 @default.
- W4283271519 hasConcept C121608353 @default.
- W4283271519 hasConcept C126322002 @default.
- W4283271519 hasConcept C143998085 @default.
- W4283271519 hasConcept C201903717 @default.
- W4283271519 hasConcept C2776256026 @default.
- W4283271519 hasConcept C2780221984 @default.
- W4283271519 hasConcept C71924100 @default.
- W4283271519 hasConcept C72563966 @default.
- W4283271519 hasConceptScore W4283271519C121608353 @default.
- W4283271519 hasConceptScore W4283271519C126322002 @default.
- W4283271519 hasConceptScore W4283271519C143998085 @default.
- W4283271519 hasConceptScore W4283271519C201903717 @default.
- W4283271519 hasConceptScore W4283271519C2776256026 @default.
- W4283271519 hasConceptScore W4283271519C2780221984 @default.