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- W4283272326 abstract "The SARS-CoV-2 virus has evolved into new strains that increase viral transmissibility and reduce vaccine protection. The rapid circulation of these more harmful strains across the globe has created a pressing need for alternative public health screening tools. REVEALR (RNA-encoded viral nucleic acid analytic reporter), a rapid and highly sensitive DNAzyme-based detection system, functions with perfect accuracy against patient-derived clinical samples. Here, we design REVEALR into a novel genotyping assay that detects single-base mismatches corresponding to each of the major SARS-CoV-2 strains found in the United States. Of 34 sequence-verified patient samples collected in early, mid, and late 2021 at the UCI Medical Center in Orange, California, REVEALR identified the correct variant [Wuhan-Hu-1, alpha (B.1.1.7), gamma (P.1), epsilon (B.1.427/9), delta (B.1.617.2), and omicron (B.1.1.529)] with 100% accuracy. The assay, which is programmable and amenable to multiplexing, offers an important new approach to personalized diagnostics." @default.
- W4283272326 created "2022-06-23" @default.
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- W4283272326 date "2022-06-21" @default.
- W4283272326 modified "2023-09-26" @default.
- W4283272326 title "REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples" @default.
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- W4283272326 doi "https://doi.org/10.1021/jacs.2c03420" @default.
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