FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283276048> ?p ?o ?g. }

• W4283276048 endingPage "e004416" @default.
• W4283276048 startingPage "e004416" @default.
• W4283276048 abstract "The development of cancer vaccines to induce tumor-antigen specific immune responses was sparked by the identification of antigens specific to or overexpressed in cancer cells. However, weak immunogenicity and the mutational heterogeneity in many cancers have dampened cancer vaccine successes. With increasing information about mutational landscapes of cancers, mutational neoantigens can be predicted computationally to elicit strong immune responses by CD8 +cytotoxic T cells as major mediators of anticancer immune response. Neoantigens are potentially more robust immunogens and have revived interest in cancer vaccines. Cancers with deficiency in DNA mismatch repair have an exceptionally high mutational burden, including predictable neoantigens. Lynch syndrome is the most common inherited cancer syndrome and is caused by DNA mismatch repair gene mutations. Insertion and deletion mutations in coding microsatellites that occur during DNA replication include tumorigenesis drivers. The induced shift of protein reading frame generates neoantigens that are foreign to the immune system. Mismatch repair-deficient cancers and Lynch syndrome represent a paradigm population for the development of a preventive cancer vaccine, as the mutations induced by mismatch repair deficiency are predictable, resulting in a defined set of frameshift peptide neoantigens. Furthermore, Lynch syndrome mutation carriers constitute an identifiable high-risk population. We discuss the pathogenesis of DNA mismatch repair deficient cancers, in both Lynch syndrome and sporadic microsatellite-unstable cancers. We review evidence for pre-existing immune surveillance, the three mechanisms of immune evasion that occur in cancers and assess the implications of a preventive frameshift peptide neoantigen-based vaccine. We consider both preclinical and clinical experience to date. We discuss the feasibility of a cancer preventive vaccine for Lynch syndrome carriers and review current antigen selection and delivery strategies. Finally, we propose RNA vaccines as having robust potential for immunoprevention of Lynch syndrome cancers." @default.
• W4283276048 created "2022-06-23" @default.
• W4283276048 creator A5010735872 @default.
• W4283276048 creator A5018576647 @default.
• W4283276048 creator A5040643638 @default.
• W4283276048 creator A5062384041 @default.
• W4283276048 creator A5079885079 @default.
• W4283276048 creator A5081455399 @default.
• W4283276048 date "2022-06-01" @default.
• W4283276048 modified "2023-10-10" @default.
• W4283276048 title "Vaccines for immunoprevention of DNA mismatch repair deficient cancers" @default.
• W4283276048 cites W1247951957 @default.
• W4283276048 cites W1488187260 @default.
• W4283276048 cites W1530219086 @default.
• W4283276048 cites W1537945509 @default.
• W4283276048 cites W1564805122 @default.
• W4283276048 cites W1592224632 @default.
• W4283276048 cites W1688526230 @default.
• W4283276048 cites W1938515409 @default.
• W4283276048 cites W1940241680 @default.
• W4283276048 cites W1965296351 @default.
• W4283276048 cites W1966365850 @default.
• W4283276048 cites W1980190087 @default.
• W4283276048 cites W1994993231 @default.
• W4283276048 cites W2004150448 @default.
• W4283276048 cites W2006149098 @default.
• W4283276048 cites W2011458181 @default.
• W4283276048 cites W2014985358 @default.
• W4283276048 cites W2032231392 @default.
• W4283276048 cites W2033632793 @default.
• W4283276048 cites W2037817507 @default.
• W4283276048 cites W2040927104 @default.
• W4283276048 cites W2041146525 @default.
• W4283276048 cites W2044433401 @default.
• W4283276048 cites W2044702943 @default.
• W4283276048 cites W2051584526 @default.
• W4283276048 cites W2067366953 @default.
• W4283276048 cites W2068022193 @default.
• W4283276048 cites W2069330243 @default.
• W4283276048 cites W2072000048 @default.
• W4283276048 cites W2072186927 @default.
• W4283276048 cites W2073673847 @default.
• W4283276048 cites W2077858999 @default.
• W4283276048 cites W2079530127 @default.
• W4283276048 cites W2084799522 @default.
• W4283276048 cites W2085289502 @default.
• W4283276048 cites W2090109598 @default.
• W4283276048 cites W2094244560 @default.
• W4283276048 cites W2094366129 @default.
• W4283276048 cites W2095874417 @default.
• W4283276048 cites W2096283457 @default.
• W4283276048 cites W2096331487 @default.
• W4283276048 cites W2096866753 @default.
• W4283276048 cites W2109098517 @default.
• W4283276048 cites W2117692326 @default.
• W4283276048 cites W2118471749 @default.
• W4283276048 cites W2121429001 @default.
• W4283276048 cites W2123670108 @default.
• W4283276048 cites W2128471759 @default.
• W4283276048 cites W2134873481 @default.
• W4283276048 cites W2141455676 @default.
• W4283276048 cites W2142207707 @default.
• W4283276048 cites W2152061559 @default.
• W4283276048 cites W2152517822 @default.
• W4283276048 cites W2157304020 @default.
• W4283276048 cites W2160759097 @default.
• W4283276048 cites W2191157318 @default.
• W4283276048 cites W2257916459 @default.
• W4283276048 cites W2267653167 @default.
• W4283276048 cites W2272228147 @default.
• W4283276048 cites W2275877493 @default.
• W4283276048 cites W2294957859 @default.
• W4283276048 cites W2320280903 @default.
• W4283276048 cites W2339723519 @default.
• W4283276048 cites W2346799991 @default.
• W4283276048 cites W2401861683 @default.
• W4283276048 cites W2405345993 @default.
• W4283276048 cites W2508710013 @default.
• W4283276048 cites W2529308344 @default.
• W4283276048 cites W2560367415 @default.
• W4283276048 cites W2578528809 @default.
• W4283276048 cites W2586986403 @default.
• W4283276048 cites W2590497374 @default.
• W4283276048 cites W2614467908 @default.
• W4283276048 cites W2622499649 @default.
• W4283276048 cites W2727744877 @default.
• W4283276048 cites W2728365508 @default.
• W4283276048 cites W2756358680 @default.
• W4283276048 cites W2767524017 @default.
• W4283276048 cites W2774113098 @default.
• W4283276048 cites W2778750925 @default.
• W4283276048 cites W2778958106 @default.
• W4283276048 cites W2779221466 @default.
• W4283276048 cites W2790528406 @default.
• W4283276048 cites W2802141870 @default.
• W4283276048 cites W2808624099 @default.
• W4283276048 cites W2885991748 @default.
• W4283276048 cites W2889884522 @default.

• next