Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283276569> ?p ?o ?g. }
- W4283276569 abstract "Abstract Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, which significantly impact the quality of life. Transcriptome-wide association study (TWAS) was conducted to estimate both transcriptomic and genomic features of AD and detected significant associations between 31 expression quantitative loci and 25 genes. Our results replicated well-known genetic markers for AD, as well as 4 novel associated genes. Next, transcriptome meta-analysis was conducted with 5 studies retrieved from public databases and identified 5 additional novel susceptibility genes for AD. Applying the connectivity map to the results from TWAS and meta-analysis, robustly enriched perturbations were identified and their chemical or functional properties were analyzed. Here, we report the first research on integrative approaches for an AD, combining TWAS and transcriptome meta-analysis. Together, our findings could provide a comprehensive understanding of the pathophysiologic mechanisms of AD and suggest potential drug candidates as alternative treatment options." @default.
- W4283276569 created "2022-06-23" @default.
- W4283276569 creator A5016265803 @default.
- W4283276569 creator A5016434778 @default.
- W4283276569 creator A5021555928 @default.
- W4283276569 creator A5034793442 @default.
- W4283276569 creator A5057588480 @default.
- W4283276569 creator A5061231855 @default.
- W4283276569 date "2022-06-22" @default.
- W4283276569 modified "2023-10-14" @default.
- W4283276569 title "Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning" @default.
- W4283276569 cites W1509405108 @default.
- W4283276569 cites W1862448690 @default.
- W4283276569 cites W1966112698 @default.
- W4283276569 cites W1978004223 @default.
- W4283276569 cites W1981409633 @default.
- W4283276569 cites W1985665277 @default.
- W4283276569 cites W1991281849 @default.
- W4283276569 cites W2001009396 @default.
- W4283276569 cites W2001678988 @default.
- W4283276569 cites W2002797131 @default.
- W4283276569 cites W2009113274 @default.
- W4283276569 cites W2010457001 @default.
- W4283276569 cites W2018838463 @default.
- W4283276569 cites W2021459310 @default.
- W4283276569 cites W2026621669 @default.
- W4283276569 cites W2026778985 @default.
- W4283276569 cites W2034715647 @default.
- W4283276569 cites W2044660283 @default.
- W4283276569 cites W2045778704 @default.
- W4283276569 cites W2050568107 @default.
- W4283276569 cites W2051314902 @default.
- W4283276569 cites W2054630779 @default.
- W4283276569 cites W2060792731 @default.
- W4283276569 cites W2062062335 @default.
- W4283276569 cites W2073836327 @default.
- W4283276569 cites W2081334781 @default.
- W4283276569 cites W2081882488 @default.
- W4283276569 cites W2082914449 @default.
- W4283276569 cites W2085126855 @default.
- W4283276569 cites W2091453442 @default.
- W4283276569 cites W2091709805 @default.
- W4283276569 cites W2092761925 @default.
- W4283276569 cites W2098502686 @default.
- W4283276569 cites W2103017472 @default.
- W4283276569 cites W2104490718 @default.
- W4283276569 cites W2104549677 @default.
- W4283276569 cites W2107665951 @default.
- W4283276569 cites W2114104545 @default.
- W4283276569 cites W2121604817 @default.
- W4283276569 cites W2123921851 @default.
- W4283276569 cites W2130116522 @default.
- W4283276569 cites W2130410032 @default.
- W4283276569 cites W2136850043 @default.
- W4283276569 cites W2138035969 @default.
- W4283276569 cites W2138894251 @default.
- W4283276569 cites W2144656637 @default.
- W4283276569 cites W2146512944 @default.
- W4283276569 cites W2148708580 @default.
- W4283276569 cites W2153422316 @default.
- W4283276569 cites W2153860431 @default.
- W4283276569 cites W2154303475 @default.
- W4283276569 cites W2159482845 @default.
- W4283276569 cites W2159675211 @default.
- W4283276569 cites W2163693381 @default.
- W4283276569 cites W2167010218 @default.
- W4283276569 cites W2168691306 @default.
- W4283276569 cites W2168764383 @default.
- W4283276569 cites W2169774924 @default.
- W4283276569 cites W2179438025 @default.
- W4283276569 cites W2206293491 @default.
- W4283276569 cites W2209106767 @default.
- W4283276569 cites W2243398804 @default.
- W4283276569 cites W2264585211 @default.
- W4283276569 cites W2289149146 @default.
- W4283276569 cites W2290401041 @default.
- W4283276569 cites W2407035614 @default.
- W4283276569 cites W2461652168 @default.
- W4283276569 cites W2504715743 @default.
- W4283276569 cites W2528377687 @default.
- W4283276569 cites W2551843349 @default.
- W4283276569 cites W2755551844 @default.
- W4283276569 cites W2770092353 @default.
- W4283276569 cites W2782344067 @default.
- W4283276569 cites W2784115980 @default.
- W4283276569 cites W2793555126 @default.
- W4283276569 cites W2801578333 @default.
- W4283276569 cites W2808263729 @default.
- W4283276569 cites W2889501685 @default.
- W4283276569 cites W2895486342 @default.
- W4283276569 cites W2896758936 @default.
- W4283276569 cites W2900569176 @default.
- W4283276569 cites W2908925106 @default.
- W4283276569 cites W2946536068 @default.
- W4283276569 cites W2950359634 @default.
- W4283276569 cites W2950709928 @default.
- W4283276569 cites W2953357410 @default.
- W4283276569 cites W2965634882 @default.
- W4283276569 cites W2969996045 @default.
- W4283276569 cites W2980691057 @default.