Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283277906> ?p ?o ?g. }
- W4283277906 endingPage "110986" @default.
- W4283277906 startingPage "110986" @default.
- W4283277906 abstract "Regulatory T (Treg) cells play a vital role in maintaining the immunosuppressive tumor microenvironment. Lactate is a crucial metabolite in cancer and is related to tumor prognosis, metastasis, and overall survival. In this study, we focus on the effects of lactate on Treg cells. In vitro, lactate improves Treg cell stability and function, whereas lactate degradation reduces Treg cell induction, increases antitumor immunity, and decreases tumor growth in mice. Mechanistically, lactate modulates Treg cell generation through lactylation of Lys72 in MOESIN, which improves MOESIN interaction with transforming growth factor β (TGF-β) receptor I and downstream SMAD3 signaling. Cotreatment with anti-PD-1 and a lactate dehydrogenase inhibitor has a stronger antitumor effect than anti-PD-1 alone. Individuals with hepatocellular carcinoma who responded to anti-PD-1 treatment have lower levels of MOESIN lactylation in Treg cells than nonresponding individuals. Thus, we identify lactate as an essential small molecule that reinforces Treg cells in the tumor microenvironment through lactylation." @default.
- W4283277906 created "2022-06-23" @default.
- W4283277906 creator A5015195367 @default.
- W4283277906 creator A5018453894 @default.
- W4283277906 creator A5023562603 @default.
- W4283277906 creator A5025500614 @default.
- W4283277906 creator A5039366205 @default.
- W4283277906 creator A5063917935 @default.
- W4283277906 creator A5064911097 @default.
- W4283277906 creator A5069748654 @default.
- W4283277906 creator A5073989265 @default.
- W4283277906 creator A5076894669 @default.
- W4283277906 creator A5083117273 @default.
- W4283277906 creator A5089968146 @default.
- W4283277906 creator A5090278539 @default.
- W4283277906 date "2022-06-01" @default.
- W4283277906 modified "2023-10-18" @default.
- W4283277906 title "Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells" @default.
- W4283277906 cites W1973091654 @default.
- W4283277906 cites W1999227421 @default.
- W4283277906 cites W2020293242 @default.
- W4283277906 cites W2023994374 @default.
- W4283277906 cites W2026426963 @default.
- W4283277906 cites W2038381158 @default.
- W4283277906 cites W2041024692 @default.
- W4283277906 cites W2049964698 @default.
- W4283277906 cites W2054738595 @default.
- W4283277906 cites W2097995306 @default.
- W4283277906 cites W2114027214 @default.
- W4283277906 cites W2115346550 @default.
- W4283277906 cites W2123363005 @default.
- W4283277906 cites W2126938326 @default.
- W4283277906 cites W2130503287 @default.
- W4283277906 cites W2218851706 @default.
- W4283277906 cites W2511460275 @default.
- W4283277906 cites W2530067632 @default.
- W4283277906 cites W2592818938 @default.
- W4283277906 cites W2607103422 @default.
- W4283277906 cites W2607137647 @default.
- W4283277906 cites W2622008929 @default.
- W4283277906 cites W2737046088 @default.
- W4283277906 cites W2740495409 @default.
- W4283277906 cites W2762717139 @default.
- W4283277906 cites W2808009807 @default.
- W4283277906 cites W2888198746 @default.
- W4283277906 cites W2898668831 @default.
- W4283277906 cites W2941582519 @default.
- W4283277906 cites W2946663348 @default.
- W4283277906 cites W2979589768 @default.
- W4283277906 cites W2982216374 @default.
- W4283277906 cites W2997323937 @default.
- W4283277906 cites W2998833691 @default.
- W4283277906 cites W3005469631 @default.
- W4283277906 cites W3133076643 @default.
- W4283277906 cites W3153466307 @default.
- W4283277906 cites W3164283778 @default.
- W4283277906 cites W4210767928 @default.
- W4283277906 doi "https://doi.org/10.1016/j.celrep.2022.110986" @default.
- W4283277906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35732125" @default.
- W4283277906 hasPublicationYear "2022" @default.
- W4283277906 type Work @default.
- W4283277906 citedByCount "56" @default.
- W4283277906 countsByYear W42832779062022 @default.
- W4283277906 countsByYear W42832779062023 @default.
- W4283277906 crossrefType "journal-article" @default.
- W4283277906 hasAuthorship W4283277906A5015195367 @default.
- W4283277906 hasAuthorship W4283277906A5018453894 @default.
- W4283277906 hasAuthorship W4283277906A5023562603 @default.
- W4283277906 hasAuthorship W4283277906A5025500614 @default.
- W4283277906 hasAuthorship W4283277906A5039366205 @default.
- W4283277906 hasAuthorship W4283277906A5063917935 @default.
- W4283277906 hasAuthorship W4283277906A5064911097 @default.
- W4283277906 hasAuthorship W4283277906A5069748654 @default.
- W4283277906 hasAuthorship W4283277906A5073989265 @default.
- W4283277906 hasAuthorship W4283277906A5076894669 @default.
- W4283277906 hasAuthorship W4283277906A5083117273 @default.
- W4283277906 hasAuthorship W4283277906A5089968146 @default.
- W4283277906 hasAuthorship W4283277906A5090278539 @default.
- W4283277906 hasBestOaLocation W42832779061 @default.
- W4283277906 hasConcept C118131993 @default.
- W4283277906 hasConcept C142669718 @default.
- W4283277906 hasConcept C1491633281 @default.
- W4283277906 hasConcept C181199279 @default.
- W4283277906 hasConcept C185592680 @default.
- W4283277906 hasConcept C203014093 @default.
- W4283277906 hasConcept C2776107976 @default.
- W4283277906 hasConcept C2776292417 @default.
- W4283277906 hasConcept C2777318727 @default.
- W4283277906 hasConcept C2780246058 @default.
- W4283277906 hasConcept C2910680157 @default.
- W4283277906 hasConcept C502942594 @default.
- W4283277906 hasConcept C55493867 @default.
- W4283277906 hasConcept C86803240 @default.
- W4283277906 hasConcept C8891405 @default.
- W4283277906 hasConcept C95444343 @default.
- W4283277906 hasConceptScore W4283277906C118131993 @default.
- W4283277906 hasConceptScore W4283277906C142669718 @default.
- W4283277906 hasConceptScore W4283277906C1491633281 @default.