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- W4283278041 endingPage "R142" @default.
- W4283278041 startingPage "R123" @default.
- W4283278041 abstract "The dysregulation of the splicing process has emerged as a novel hallmark of metabolic and tumor pathologies. In breast cancer (BCa), which represents the most diagnosed cancer type among women worldwide, the generation and/or dysregulation of several oncogenic splicing variants have been described. This is the case of the splicing variants of HER2, ER, BRCA1, or the recently identified by our group, In1-ghrelin and SST5TMD4, which exhibit oncogenic roles, increasing the malignancy, poor prognosis, and resistance to treatment of BCa. This altered expression of oncogenic splicing variants has been closely linked with the dysregulation of the elements belonging to the macromolecular machinery that controls the splicing process (spliceosome components and the associated splicing factors). In this review, we compile the current knowledge demonstrating the altered expression of splicing variants and spliceosomal components in BCa, showing the existence of a growing body of evidence supporting the close implication of the alteration in the splicing process in mammary tumorigenesis." @default.
- W4283278041 created "2022-06-23" @default.
- W4283278041 creator A5008544375 @default.
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- W4283278041 creator A5026451614 @default.
- W4283278041 creator A5034617266 @default.
- W4283278041 creator A5081006348 @default.
- W4283278041 date "2022-09-01" @default.
- W4283278041 modified "2023-10-10" @default.
- W4283278041 title "Dysregulation of splicing variants and spliceosome components in breast cancer" @default.
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