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• W4283278199 abstract "HomeCirculation: Cardiovascular ImagingVol. 15, No. 6In This Issue of the Journal Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBIn This Issue of the Journal Robert J. Gropler Robert J. GroplerRobert J. Gropler https://orcid.org/0000-0002-6550-0570 Search for more papers by this author Originally published21 Jun 2022https://doi.org/10.1161/CIRCIMAGING.122.014517Circulation: Cardiovascular Imaging. 2022;15I want to welcome you to the June 2022 issue of Circulation: Cardiovascular Imaging. The issue highlights advances in imaging to better understand and detect congenital and pediatric heart disease, to potentially provide more personalized antilipid therapy, and to bring quantification of myocardial blood flow by single-photon emission computed tomography (SPECT) closer to clinical reality and that signals the promise of theragnostics in the management of the cardiovascular disease patient.Left ventricular noncompaction, characterized by excessive trabeculations of the left ventricle, is associated with adverse outcomes such as left ventricular arrhythmias, thromboembolism, and various forms of cardiomyopathy. There is still uncertainty regarding its etiology, how to distinguish it from normal variants, and its prevalence. Based on neonatal echocardiography, Børresen and colleagues provide evidence to suggest the prevalence of left ventricular noncompaction is <0.08%, is likely a form of cardiomyopathy, and establishing accurate echocardiographic diagnostic criterion may be possible. In their commentary, Towbin and Johnson provide important contextualization of the study results with current knowledge and raise the point that marked phenotypic heterogeneity in left ventricular noncompaction may have led to its underestimation in the study.Myocardial ischemia detected with earlier generation SPECT cameras and semiquantitative perfusion has demonstrated an association with a worse prognosis in women compared with men. Whether similar observations are observed using newer cadmium zinc telluride detector SPECT cameras and perfusion abnormality severity quantification software is unknown. Employing these 2 technologies, Tamarappoo et al confirm similar findings that moderate and severe ischemia is associated with a worse prognosis in women compared to men. Although requiring further investigation their observations suggest this SPECT approach may identify women who would benefit from more aggressive therapeutic interventions.There is an independent association of thoracic aortic calcification with atherosclerotic cardiovascular disease events and mortality, suggesting the detection of calcium at this site may bring complementary information to clinical evaluation and coronary artery calcium scoring. Castagna and colleagues provide evidence that in patients without history of atherosclerotic cardiovascular disease and severe hypercholesterolemia (LDL-C [low-density lipoprotein-cholesterol] ≥190 mg/dL), the presence and severity of coronary artery calcium and thoracic aorta calcium detected by x-ray nongated computed tomography are independently associated with all-cause mortality. Continuing Medical Education credit is offered for this article. In his editorial, Santos nicely positions where these results may potentially help guide more personalized lipid-lowering management in these patients.The quantification of myocardial blood flow at rest and stress is typically performed by positron emission tomography, but with the advent of cadmium zinc telluride detectors, there is growing interest in the performance of these flow measurements with newer SPECT cameras that incorporate this technology. De Souza et al report that employing these new cameras and more advanced reconstruction algorithms both improves the correlation of SPECT-derived blood flow measurements with those measured with positron emission tomography and reduces intertest variability.Theragnostics, the combining of imaging agents with both diagnostic capacity and targeted therapy delivery, are commonly used in oncology and emerging in the treatment of cardiovascular disease. Ramirez-Carracedo and colleagues provide evidence in a pig model of myocardial infarction of a combined functionalized nanomaterial and magnetic resonance approach to both reduce extracellular matrix degradation and noninvasively visualize cardiac necrosis progression following injury. In their commentary, Thackeray and Hess concisely and accurately summarize the strengths and weaknesses of the approach and what advances are needed before theragnostics become a more common staple in the management of patients with cardiovascular disease.In the Cardiovascular Images section, DiLorenzo et al present an example where cardiac magnetic resonance derived four-dimensional flow imaging was used to evaluate shunt flow in a unidirectional valve Potts shunt. Vidula and colleagues report on how multimodality imaging aided in the diagnosis of cardiac sarcoidosis masquerading as a septal myocardial infarction. Liu et al describe how multimodality imaging were vital contributors to the diagnosis and management of patient with an atrioventricular septal pseudoaneurysm complicating endocarditis. Zhang and colleagues present a case demonstrating the role of echocardiography and cardiac computed tomographic angiography in diagnosis of an unruptured aneurysm in the left sinus of Valsalva as the cause of a patient’s dysphagia.In a document generated by contributors from Society for Cardiovascular Magnetic Resonance/European Society of Cardiovascular Imaging/American Society of Echocardiography/Society for Pediatric Radiology/North American Society for Cardiovascular Imaging, and endorsed by the American Heart Association, imaging guidelines are presented based on the existing literature supporting cardiac magnetic resonance imaging for commonly encountered pediatric congenital and acquired pediatric heart disease.I thank you for reading Circulation: Cardiovascular Imaging and hope you enjoyed reading the various pieces. We look forward to your future visits to the journal.Disclosures Disclosures provided by Dr Gropler in compliance with American Heart Association’s annual Journal Editor Disclosure Questionnaire are available at https://www.ahajournals.org/pb-assets/policies/COI_03_2022-1646773084033.pdfFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Disclosures, see page 346. Previous Back to top Next FiguresReferencesRelatedDetails June 2022Vol 15, Issue 6 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCIMAGING.122.014517 Originally publishedJune 21, 2022 PDF download Advertisement" @default.
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