Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283278531> ?p ?o ?g. }
- W4283278531 endingPage "166466" @default.
- W4283278531 startingPage "166466" @default.
- W4283278531 abstract "Identification of molecular targets in any cellular phenomena is a challenge and a path that one endeavors upon independently. We have identified a phosphatase SHP-1 as a point of intervention of IL-10 and IL-12 reciprocity in leishmaniasis. The therapeutic model that we have developed uniquely targets this protein but the pipeline in general can be used by the researchers for their unique targets. Naturally occurring peptides are well known for their biochemical participation in cellular functions hence we were motivated to use this uniqueness of physico-chemical properties of peptides conferred by amino acids through machine learning to channelize a mode of therapeutic exploration in infectious disease. Using computational approaches, we identified high order sequence conservation and similarity in SHP-1 sequence which was also evolutionarily conserved, complete structure of Mouse SHP-1 was predicted and validated, a unique motif of the same was identified against which library of synthetic peptides were designed and validated followed by screening the library by docking them with MuSHP-1 protein structure. Our findings showed 3 peptides had high binding affinity and in future can be validated using cell based and in vivo assays." @default.
- W4283278531 created "2022-06-23" @default.
- W4283278531 creator A5009949680 @default.
- W4283278531 creator A5085151831 @default.
- W4283278531 date "2022-10-01" @default.
- W4283278531 modified "2023-10-09" @default.
- W4283278531 title "Artificial intelligence channelizing protein-peptide interactions pipeline for host-parasite paradigm in IL-10 and IL-12 reciprocity by SHP-1" @default.
- W4283278531 cites W1482971402 @default.
- W4283278531 cites W1494484168 @default.
- W4283278531 cites W1590648220 @default.
- W4283278531 cites W1595347157 @default.
- W4283278531 cites W1606947757 @default.
- W4283278531 cites W1709815505 @default.
- W4283278531 cites W1975614186 @default.
- W4283278531 cites W1981489800 @default.
- W4283278531 cites W1985127008 @default.
- W4283278531 cites W1990738958 @default.
- W4283278531 cites W1992192767 @default.
- W4283278531 cites W1992450378 @default.
- W4283278531 cites W2011615074 @default.
- W4283278531 cites W2023105803 @default.
- W4283278531 cites W2027452916 @default.
- W4283278531 cites W2041386815 @default.
- W4283278531 cites W2046033677 @default.
- W4283278531 cites W2054352267 @default.
- W4283278531 cites W2057811708 @default.
- W4283278531 cites W2061543974 @default.
- W4283278531 cites W2066806519 @default.
- W4283278531 cites W2068852897 @default.
- W4283278531 cites W2074473216 @default.
- W4283278531 cites W2083734879 @default.
- W4283278531 cites W2099861795 @default.
- W4283278531 cites W2101464035 @default.
- W4283278531 cites W2105668062 @default.
- W4283278531 cites W2107710616 @default.
- W4283278531 cites W2115865500 @default.
- W4283278531 cites W2145957695 @default.
- W4283278531 cites W2148698435 @default.
- W4283278531 cites W2152705149 @default.
- W4283278531 cites W2153983456 @default.
- W4283278531 cites W2154019529 @default.
- W4283278531 cites W2161444534 @default.
- W4283278531 cites W2163776261 @default.
- W4283278531 cites W2167028704 @default.
- W4283278531 cites W2167352194 @default.
- W4283278531 cites W2217411574 @default.
- W4283278531 cites W2315260707 @default.
- W4283278531 cites W2323889349 @default.
- W4283278531 cites W2385093112 @default.
- W4283278531 cites W2547542486 @default.
- W4283278531 cites W2552080741 @default.
- W4283278531 cites W2730968108 @default.
- W4283278531 cites W2768092025 @default.
- W4283278531 cites W2780124787 @default.
- W4283278531 cites W2801891815 @default.
- W4283278531 cites W2804822363 @default.
- W4283278531 cites W2924715631 @default.
- W4283278531 cites W2952209472 @default.
- W4283278531 cites W2999044305 @default.
- W4283278531 cites W2999580270 @default.
- W4283278531 cites W3017283277 @default.
- W4283278531 cites W3088517205 @default.
- W4283278531 cites W3108943181 @default.
- W4283278531 cites W3127535326 @default.
- W4283278531 cites W3164293466 @default.
- W4283278531 cites W3185197558 @default.
- W4283278531 cites W3187084829 @default.
- W4283278531 cites W3199607358 @default.
- W4283278531 cites W4212959738 @default.
- W4283278531 cites W4226191033 @default.
- W4283278531 cites W4247412012 @default.
- W4283278531 doi "https://doi.org/10.1016/j.bbadis.2022.166466" @default.
- W4283278531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35750267" @default.
- W4283278531 hasPublicationYear "2022" @default.
- W4283278531 type Work @default.
- W4283278531 citedByCount "3" @default.
- W4283278531 countsByYear W42832785312022 @default.
- W4283278531 countsByYear W42832785312023 @default.
- W4283278531 crossrefType "journal-article" @default.
- W4283278531 hasAuthorship W4283278531A5009949680 @default.
- W4283278531 hasAuthorship W4283278531A5085151831 @default.
- W4283278531 hasBestOaLocation W42832785311 @default.
- W4283278531 hasConcept C104317684 @default.
- W4283278531 hasConcept C15744967 @default.
- W4283278531 hasConcept C159110408 @default.
- W4283278531 hasConcept C167625842 @default.
- W4283278531 hasConcept C169903001 @default.
- W4283278531 hasConcept C199216141 @default.
- W4283278531 hasConcept C2775905019 @default.
- W4283278531 hasConcept C2779281246 @default.
- W4283278531 hasConcept C41685203 @default.
- W4283278531 hasConcept C55493867 @default.
- W4283278531 hasConcept C60644358 @default.
- W4283278531 hasConcept C70721500 @default.
- W4283278531 hasConcept C71924100 @default.
- W4283278531 hasConcept C77805123 @default.
- W4283278531 hasConcept C86803240 @default.
- W4283278531 hasConceptScore W4283278531C104317684 @default.