FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283315219> ?p ?o ?g. }

• W4283315219 abstract "Mesangial cell proliferation is the most basic pathological feature of immunoglobulin A nephropathy (IgAN); however, the specific underlying mechanism and an appropriate therapeutic strategy are yet to be unearthed. This study aimed to investigate the therapeutic effect of triptolide (TP) on IgAN and the mechanism by which TP regulates autophagy and proliferation of mesangial cells through the CARD9/p38 MAPK pathway.We established a TP-treated IgAN mouse model and produced IgA1-induced human mesangial cells (HMC) and divided them into control, TP, IgAN, and IgAN+TP groups. The levels of mesangial cell proliferation (PCNA, cyclin D1, cell viability, and cell cycle) and autophagy (P62, LC3 II, and autophagy flux rate) were measured, with the autophagy inhibitor 3-Methyladenine used to explore the relationship between autophagy and proliferation. We observed CARD9 expression in renal biopsies from patients and analyzed its clinical significance. CARD9 siRNA and overexpression plasmids were constructed to investigate the changes in mesangial cell proliferation and autophagy as well as the expression of CARD9 and p-p38 MAPK/p38 MAPK following TP treatment.Administering TP was safe and effectively alleviated mesangial cell proliferation in IgAN mice. Moreover, TP inhibited IgA1-induced HMC proliferation by promoting autophagy. The high expression of CARD9 in IgAN patients was positively correlated with the severity of HMC proliferation. CARD9/p38 MAPK was involved in the regulation of HMC autophagy and proliferation, and TP promoted autophagy to inhibit HMC proliferation by downregulating the CARD9/p38 MAPK pathway in IgAN.TP promotes autophagy to inhibit mesangial cell proliferation in IgAN via the CARD9/p38 MAPK pathway." @default.
• W4283315219 created "2022-06-24" @default.
• W4283315219 creator A5003986323 @default.
• W4283315219 creator A5006219225 @default.
• W4283315219 creator A5023246660 @default.
• W4283315219 creator A5024630056 @default.
• W4283315219 creator A5038164471 @default.
• W4283315219 creator A5047729392 @default.
• W4283315219 creator A5055415805 @default.
• W4283315219 creator A5061161052 @default.
• W4283315219 creator A5063731595 @default.
• W4283315219 date "2022-06-22" @default.
• W4283315219 modified "2023-10-01" @default.
• W4283315219 title "Triptolide promotes autophagy to inhibit mesangial cell proliferation in <scp>IgA</scp> nephropathy via the <scp>CARD9</scp> /p38 <scp>MAPK</scp> pathway" @default.
• W4283315219 cites W1053229649 @default.
• W4283315219 cites W1764833860 @default.
• W4283315219 cites W1786936643 @default.
• W4283315219 cites W1854855033 @default.
• W4283315219 cites W1861460734 @default.
• W4283315219 cites W1963651279 @default.
• W4283315219 cites W1983056074 @default.
• W4283315219 cites W2013334482 @default.
• W4283315219 cites W2018030039 @default.
• W4283315219 cites W2035077546 @default.
• W4283315219 cites W2044349121 @default.
• W4283315219 cites W2055934272 @default.
• W4283315219 cites W2093123098 @default.
• W4283315219 cites W2101794801 @default.
• W4283315219 cites W2144669742 @default.
• W4283315219 cites W2146707343 @default.
• W4283315219 cites W2152313851 @default.
• W4283315219 cites W2173758082 @default.
• W4283315219 cites W2179430785 @default.
• W4283315219 cites W2212745154 @default.
• W4283315219 cites W2270874783 @default.
• W4283315219 cites W2274509164 @default.
• W4283315219 cites W2298438499 @default.
• W4283315219 cites W2508407337 @default.
• W4283315219 cites W2554784349 @default.
• W4283315219 cites W2560254398 @default.
• W4283315219 cites W2590862768 @default.
• W4283315219 cites W2604202439 @default.
• W4283315219 cites W2694013831 @default.
• W4283315219 cites W2727604819 @default.
• W4283315219 cites W2734350307 @default.
• W4283315219 cites W2749881696 @default.
• W4283315219 cites W2762797603 @default.
• W4283315219 cites W2768203510 @default.
• W4283315219 cites W2770135338 @default.
• W4283315219 cites W2790060323 @default.
• W4283315219 cites W2793756857 @default.
• W4283315219 cites W2807427890 @default.
• W4283315219 cites W2886946434 @default.
• W4283315219 cites W2902766347 @default.
• W4283315219 cites W2912486502 @default.
• W4283315219 cites W2921241315 @default.
• W4283315219 cites W2937346600 @default.
• W4283315219 cites W2941163443 @default.
• W4283315219 cites W2944016191 @default.
• W4283315219 cites W2944914827 @default.
• W4283315219 cites W2947966654 @default.
• W4283315219 cites W2968120435 @default.
• W4283315219 cites W2980207850 @default.
• W4283315219 cites W2983388001 @default.
• W4283315219 cites W2983986890 @default.
• W4283315219 cites W2995839953 @default.
• W4283315219 cites W2999975329 @default.
• W4283315219 cites W3002332896 @default.
• W4283315219 cites W3004540243 @default.
• W4283315219 cites W3007417926 @default.
• W4283315219 cites W3014752547 @default.
• W4283315219 cites W3029001185 @default.
• W4283315219 cites W3040966078 @default.
• W4283315219 cites W3044253363 @default.
• W4283315219 cites W3086575470 @default.
• W4283315219 cites W3092966039 @default.
• W4283315219 cites W3096433340 @default.
• W4283315219 cites W3108936441 @default.
• W4283315219 cites W3111996400 @default.
• W4283315219 cites W3166327631 @default.
• W4283315219 cites W3185961892 @default.
• W4283315219 cites W3192520214 @default.
• W4283315219 cites W3200262041 @default.
• W4283315219 cites W3200479416 @default.
• W4283315219 cites W3205609245 @default.
• W4283315219 cites W3217207941 @default.
• W4283315219 cites W4200134907 @default.
• W4283315219 cites W4210799840 @default.
• W4283315219 cites W4211190065 @default.
• W4283315219 cites W4212982349 @default.
• W4283315219 cites W4213151738 @default.
• W4283315219 cites W4213450653 @default.
• W4283315219 cites W4214857568 @default.
• W4283315219 cites W4247172809 @default.
• W4283315219 cites W4283315219 @default.
• W4283315219 cites W2884394058 @default.
• W4283315219 doi "https://doi.org/10.1111/cpr.13278" @default.
• W4283315219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35733381" @default.
• W4283315219 hasPublicationYear "2022" @default.
• W4283315219 type Work @default.

• next