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• W4283315285 endingPage "7445" @default.
• W4283315285 startingPage "7428" @default.
• W4283315285 abstract "Serine‐arginine protein kinase 1 (SRPK1) phosphorylates serine‐arginine (SR) proteins in the cytoplasm, directing them to the nucleus for splicing function. SRPK1 has also been detected in the nucleus but its function here is still not fully understood. We now demonstrate that nuclear SRPK1 can regulate U1‐70K, a protein component of the uridine‐rich 1 small nuclear ribonucleoprotein (U1 snRNP) that binds SR proteins and facilitates 5′ splice‐site selection in precursor mRNA. We found that SRPK1 uses a large, disordered domain to bind U1‐70K, regulating the interaction of an exonic splicing enhancer (ESE) to the associated SR protein. Surprisingly, the catalytic activity of SRPK1 is not required for this phenomenon. Instead, SRPK1 associates directly with the N‐terminus of U1‐70K and alters the regulatory function of the distal C‐terminus, modifying interactions between the U1‐70K:SR protein complex and the ESE. Disruption of SRPK1 binding to this complex affects the alternative splicing of genes modulated by the C‐terminus of U1‐70K. Such findings suggest that, in addition to operating as a traditional serine‐modifying catalyst, SRPK1 can also bypass this intrinsic activity to regulate RNA contacts in an early pre‐spliceosomal complex." @default.
• W4283315285 created "2022-06-24" @default.
• W4283315285 creator A5028075560 @default.
• W4283315285 creator A5071114438 @default.
• W4283315285 date "2022-07-02" @default.
• W4283315285 modified "2023-10-12" @default.
• W4283315285 title "<scp>SRPK1</scp> regulates <scp>RNA</scp> binding in a pre‐spliceosomal complex using a catalytic bypass mechanism" @default.
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• W4283315285 doi "https://doi.org/10.1111/febs.16560" @default.
• W4283315285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35730996" @default.
• W4283315285 hasPublicationYear "2022" @default.
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