FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283315337> ?p ?o ?g. }

• W4283315337 endingPage "e2218371" @default.
• W4283315337 startingPage "e2218371" @default.
• W4283315337 abstract "Temporal shifts in clinical knowledge and practice need to be adjusted for in treatment outcome assessment in clinical evidence.To use electronic health record (EHR) data to (1) assess the temporal trends in treatment decisions and patient outcomes and (2) emulate a randomized clinical trial (RCT) using EHR data with proper adjustment for temporal trends.The Clinical Outcomes of Surgical Therapy (COST) Study Group Trial assessing overall survival of patients with stages I to III early-stage colon cancer was chosen as the target trial. The RCT was emulated using EHR data of patients from a single health care system cohort who underwent colectomy for early-stage colon cancer from January 1, 2006, to December 31, 2017, and were followed up to January 1, 2020, from Mass General Brigham. Analyses were conducted from December 2, 2019, to January 24, 2022.Laparoscopy-assisted colectomy (LAC) vs open colectomy (OC).The primary outcome was 5-year overall survival. To address confounding in the emulation, pretreatment variables were selected and adjusted. The temporal trends were adjusted by stratification of the calendar year when the colectomies were performed with cotraining across strata.A total of 943 patients met key RCT eligibility criteria in the EHR emulation cohort, including 518 undergoing LAC (median age, 63 [range, 20-95] years; 268 [52%] women; 121 [23%] with stage I, 165 [32%] with stage II, and 232 [45%] with stage III cancer; 32 [6%] with colon adhesion; 278 [54%] with right-sided colon cancer; 18 [3%] with left-sided colon cancer; and 222 [43%] with sigmoid colon cancer) and 425 undergoing OC (median age, 65 [range, 28-99] years; 223 [52%] women; 61 [14%] with stage I, 153 [36%] with stage II, and 211 [50%] with stage III cancer; 39 [9%] with colon adhesion; 202 [47%] with right-sided colon cancer; 39 [9%] with left-sided colon cancer; and 201 [47%] with sigmoid colon cancer). Tests for temporal trends in treatment assignment (χ2 = 60.3; P < .001) and overall survival (χ2 = 137.2; P < .001) were significant. The adjusted EHR emulation reached the same conclusion as the RCT: LAC is not inferior to OC in overall survival rate with risk difference at 5 years of -0.007 (95% CI, -0.070 to 0.057). The results were consistent for stratified analysis within each temporal period.These findings suggest that confounding bias from temporal trends should be considered when conducting clinical evidence studies with long time spans. Stratification of calendar time and cotraining of models is one solution. With proper adjustment, clinical evidence may supplement RCTs in the assessment of treatment outcome over time." @default.
• W4283315337 created "2022-06-24" @default.
• W4283315337 creator A5007063265 @default.
• W4283315337 creator A5010460004 @default.
• W4283315337 creator A5010591771 @default.
• W4283315337 creator A5012743705 @default.
• W4283315337 creator A5023428054 @default.
• W4283315337 creator A5025181406 @default.
• W4283315337 creator A5030466570 @default.
• W4283315337 creator A5037229611 @default.
• W4283315337 creator A5039783332 @default.
• W4283315337 creator A5072804718 @default.
• W4283315337 creator A5077299550 @default.
• W4283315337 creator A5078003862 @default.
• W4283315337 creator A5081350789 @default.
• W4283315337 creator A5086840858 @default.
• W4283315337 creator A5090197328 @default.
• W4283315337 date "2022-06-23" @default.
• W4283315337 modified "2023-10-18" @default.
• W4283315337 title "Temporal Trends in Clinical Evidence of 5-Year Survival Within Electronic Health Records Among Patients With Early-Stage Colon Cancer Managed With Laparoscopy-Assisted Colectomy vs Open Colectomy" @default.
• W4283315337 cites W1607229324 @default.
• W4283315337 cites W1969208427 @default.
• W4283315337 cites W1975108706 @default.
• W4283315337 cites W2020925091 @default.
• W4283315337 cites W2040638351 @default.
• W4283315337 cites W2046172123 @default.
• W4283315337 cites W2054661578 @default.
• W4283315337 cites W2061985843 @default.
• W4283315337 cites W2078476048 @default.
• W4283315337 cites W2091015783 @default.
• W4283315337 cites W2111221432 @default.
• W4283315337 cites W2137370054 @default.
• W4283315337 cites W2185791496 @default.
• W4283315337 cites W2586254558 @default.
• W4283315337 cites W2612779639 @default.
• W4283315337 cites W2613381978 @default.
• W4283315337 cites W2618857274 @default.
• W4283315337 cites W2768945936 @default.
• W4283315337 cites W2775269156 @default.
• W4283315337 cites W2786472999 @default.
• W4283315337 cites W2810688527 @default.
• W4283315337 cites W2913729906 @default.
• W4283315337 cites W2948551797 @default.
• W4283315337 cites W2965414772 @default.
• W4283315337 cites W2966630186 @default.
• W4283315337 cites W2976369321 @default.
• W4283315337 cites W2986924890 @default.
• W4283315337 cites W3000283591 @default.
• W4283315337 cites W3003670850 @default.
• W4283315337 cites W3014125475 @default.
• W4283315337 cites W3021713242 @default.
• W4283315337 cites W3029320863 @default.
• W4283315337 cites W3041547238 @default.
• W4283315337 cites W3112964578 @default.
• W4283315337 cites W3155678845 @default.
• W4283315337 cites W3177617320 @default.
• W4283315337 cites W3181025656 @default.
• W4283315337 cites W4205565809 @default.
• W4283315337 cites W4224433810 @default.
• W4283315337 cites W4232663638 @default.
• W4283315337 cites W4245630086 @default.
• W4283315337 cites W4250758968 @default.
• W4283315337 cites W4251423214 @default.
• W4283315337 doi "https://doi.org/10.1001/jamanetworkopen.2022.18371" @default.
• W4283315337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35737384" @default.
• W4283315337 hasPublicationYear "2022" @default.
• W4283315337 type Work @default.
• W4283315337 citedByCount "3" @default.
• W4283315337 countsByYear W42833153372023 @default.
• W4283315337 crossrefType "journal-article" @default.
• W4283315337 hasAuthorship W4283315337A5007063265 @default.
• W4283315337 hasAuthorship W4283315337A5010460004 @default.
• W4283315337 hasAuthorship W4283315337A5010591771 @default.
• W4283315337 hasAuthorship W4283315337A5012743705 @default.
• W4283315337 hasAuthorship W4283315337A5023428054 @default.
• W4283315337 hasAuthorship W4283315337A5025181406 @default.
• W4283315337 hasAuthorship W4283315337A5030466570 @default.
• W4283315337 hasAuthorship W4283315337A5037229611 @default.
• W4283315337 hasAuthorship W4283315337A5039783332 @default.
• W4283315337 hasAuthorship W4283315337A5072804718 @default.
• W4283315337 hasAuthorship W4283315337A5077299550 @default.
• W4283315337 hasAuthorship W4283315337A5078003862 @default.
• W4283315337 hasAuthorship W4283315337A5081350789 @default.
• W4283315337 hasAuthorship W4283315337A5086840858 @default.
• W4283315337 hasAuthorship W4283315337A5090197328 @default.
• W4283315337 hasBestOaLocation W42833153371 @default.
• W4283315337 hasConcept C121608353 @default.
• W4283315337 hasConcept C126322002 @default.
• W4283315337 hasConcept C141071460 @default.
• W4283315337 hasConcept C146357865 @default.
• W4283315337 hasConcept C151730666 @default.
• W4283315337 hasConcept C168563851 @default.
• W4283315337 hasConcept C201903717 @default.
• W4283315337 hasConcept C2776667177 @default.
• W4283315337 hasConcept C526805850 @default.
• W4283315337 hasConcept C535046627 @default.
• W4283315337 hasConcept C61434518 @default.
• W4283315337 hasConcept C71924100 @default.

• next