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• W4283315848 abstract "Mammalian target of rapamycin (mTOR) inhibitors-associated pneumonitis (mTOR-IP) has long been described in solid organ recipients (T) patients but more recently in cancer (K) patients. Its overall characteristics have never been compared between these 2 populations. The aim of this study was to compare them in terms of presentation, severity and outcome in T and in K patients. We carried out a retrospective study in a single French tertiary center. Four databases were used to ensure the exhaustive collection of all mTOR-IP cases between 2001 and 2020. All clinical, biological, radiological, pathological and outcome data were reviewed. Thirty-nine patients with mTOR-IP were diagnosed during this period, 24 T and 15 K patients. The average dosage of everolimus and sirolimus was 2,65 mg (±1,78) and 2,75 mg (±0,96) in T patients, respectively, versus 8,75 mg (±2,26) for everolimus in K patients. The overall prevalence of mTOR-IP was 6.4% with a median time of occurrence of 7 months [IQR 3–35 months]. mTOR-IP were significantly more frequent (P < 0.001) and occurred earlier (P < 0.001) in cancer patients. No clinical, functional, radiological, pathological nor outcome differences were otherwise observed between the 2 groups. Average everolimus blood levels at the time of mTOR-IP diagnosis were in the range of recommended therapeutic values. Our study shows that mTOR-IP is comparable in terms of presentation in T and in K patients but that it occurs significantly earlier after drug introduction in the latter. This raises questions as to the potential role of the higher doses used in K patients as well as that of co-treatments in the pathogeny of the disease." @default.
• W4283315848 created "2022-06-24" @default.
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• W4283315848 date "2023-05-01" @default.
• W4283315848 modified "2023-10-18" @default.
• W4283315848 title "Pulmonary toxicity of mTOR inhibitors. Comparisons of two populations: Solid organ recipients and cancer patients" @default.
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• W4283315848 doi "https://doi.org/10.1016/j.therap.2022.05.008" @default.
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