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- W4283323786 abstract "To examine the prevalence rates of biosimilar discontinuation and switchback to the originator tumor necrosis factor alpha (TNF) inhibitors following non-medical switch (NMS) in patients. Real-world studies reporting biosimilar discontinuation and switchback rates following NMS published between January 2012 and August 2018 were identified through a systematic literature review. A meta-analysis estimated the annualized discontinuation and switchback rates. A subsequent meta-analysis assessed annualized incremental discontinuation rate among studies reporting both discontinuation rates in patients who underwent an NMS (switchers) and patients who remained on originators (non-switchers). A total of 66 publications were identified: 31 in gastroenterology, 32 in rheumatology, and 3 in both. Half of the studies reported switchback rates; only 9 studies reported discontinuation rates for both switchers and non-switchers. Across studies, the mean/range sample size of the NMS patient population was 136/9–1641; mean/range follow-up was 10/3–24 months. Annualized biosimilar discontinuation rate was 21% (95% confidence interval [CI] 18%, 25%). Switchback rate was 14% (95% CI 10%, 17%) among all NMS patients and 62% (95% CI 44%, 80%) among discontinuers. The mean/range sample size of switchers and non-switchers was 344/89–1621 and 768/19–2870, respectively; mean/range follow-up was 11/6–18 and 12/6–8 months, respectively. Annualized incremental biosimilar discontinuation rate was 18% (95% CI 4%, 31%). Biosimilar discontinuation was found to be prevalent among patients who underwent an NMS from an originator TNF inhibitor to its biosimilar(s) in the real world. In addition, switchback to the originator TNF inhibitors was common following biosimilar discontinuation. Careful consideration is necessary when switching patients already on an originator TNF inhibitor to its biosimilar(s). Main limitations included the heterogeneity of the studies and the limited comparability of the data." @default.
- W4283323786 created "2022-06-24" @default.
- W4283323786 creator A5020577279 @default.
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- W4283323786 creator A5079729596 @default.
- W4283323786 creator A5089194015 @default.
- W4283323786 creator A5091667531 @default.
- W4283323786 date "2022-06-23" @default.
- W4283323786 modified "2023-10-10" @default.
- W4283323786 title "Discontinuation and Switchback After Non-Medical Switching from Originator Tumor Necrosis Factor Alpha (TNF) Inhibitors to Biosimilars: A Meta-Analysis of Real-World Studies from 2012 to 2018" @default.
- W4283323786 cites W113059859 @default.
- W4283323786 cites W1827882046 @default.
- W4283323786 cites W2022888597 @default.
- W4283323786 cites W2106152050 @default.
- W4283323786 cites W2106962952 @default.
- W4283323786 cites W2111913995 @default.
- W4283323786 cites W2130173462 @default.
- W4283323786 cites W2142004396 @default.
- W4283323786 cites W2148487286 @default.
- W4283323786 cites W2152721471 @default.
- W4283323786 cites W2279977120 @default.
- W4283323786 cites W2293557195 @default.
- W4283323786 cites W2321566470 @default.
- W4283323786 cites W2331712921 @default.
- W4283323786 cites W2342464058 @default.
- W4283323786 cites W2345220764 @default.
- W4283323786 cites W2407658018 @default.
- W4283323786 cites W2414751009 @default.
- W4283323786 cites W2480851940 @default.
- W4283323786 cites W2482832580 @default.
- W4283323786 cites W2521883132 @default.
- W4283323786 cites W2526345971 @default.
- W4283323786 cites W2560189970 @default.
- W4283323786 cites W2560713160 @default.
- W4283323786 cites W2581549770 @default.
- W4283323786 cites W2584947097 @default.
- W4283323786 cites W2586224233 @default.
- W4283323786 cites W2586796756 @default.
- W4283323786 cites W2586976326 @default.
- W4283323786 cites W2587065878 @default.
- W4283323786 cites W2587157414 @default.
- W4283323786 cites W2587419283 @default.
- W4283323786 cites W2593580677 @default.
- W4283323786 cites W2601366102 @default.
- W4283323786 cites W2607078238 @default.
- W4283323786 cites W2610308940 @default.
- W4283323786 cites W2613299853 @default.
- W4283323786 cites W2616264501 @default.
- W4283323786 cites W2623636343 @default.
- W4283323786 cites W2624289061 @default.
- W4283323786 cites W2661134095 @default.
- W4283323786 cites W2663689705 @default.
- W4283323786 cites W2669613733 @default.
- W4283323786 cites W2733544055 @default.
- W4283323786 cites W2741409239 @default.
- W4283323786 cites W2748149557 @default.
- W4283323786 cites W2751387666 @default.
- W4283323786 cites W2753152387 @default.
- W4283323786 cites W2753659503 @default.
- W4283323786 cites W2759349664 @default.
- W4283323786 cites W2763143648 @default.
- W4283323786 cites W2764082441 @default.
- W4283323786 cites W2766388803 @default.
- W4283323786 cites W2766795500 @default.
- W4283323786 cites W2767179430 @default.
- W4283323786 cites W2768187732 @default.
- W4283323786 cites W2774116866 @default.
- W4283323786 cites W2776453313 @default.
- W4283323786 cites W2778233154 @default.
- W4283323786 cites W2784409714 @default.
- W4283323786 cites W2786419811 @default.
- W4283323786 cites W2789319673 @default.
- W4283323786 cites W2789498468 @default.
- W4283323786 cites W2790246629 @default.
- W4283323786 cites W2791224008 @default.
- W4283323786 cites W2791325111 @default.
- W4283323786 cites W2792122651 @default.
- W4283323786 cites W2793404935 @default.
- W4283323786 cites W2793778961 @default.
- W4283323786 cites W2793866077 @default.
- W4283323786 cites W2794339583 @default.
- W4283323786 cites W2796428896 @default.
- W4283323786 cites W2799534621 @default.
- W4283323786 cites W2799608950 @default.
- W4283323786 cites W2800442651 @default.
- W4283323786 cites W2800784996 @default.
- W4283323786 cites W2801418762 @default.
- W4283323786 cites W2806215443 @default.
- W4283323786 cites W2807850779 @default.
- W4283323786 cites W2808119603 @default.
- W4283323786 cites W2808121654 @default.
- W4283323786 cites W2808526892 @default.
- W4283323786 cites W2841623998 @default.
- W4283323786 cites W2842628275 @default.
- W4283323786 cites W2883628413 @default.
- W4283323786 cites W2883934894 @default.
- W4283323786 cites W2885872617 @default.
- W4283323786 cites W2887206736 @default.